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610-66-2

610-66-2

Identification

Synonyms:Acetonitrile,(o-nitrophenyl)-(7CI,8CI);(2-Nitrophenyl)acetonitrile;(o-Nitrophenyl)acetonitrile;2-Nitrobenzeneacetonitrile;2-Nitrobenzyl cyanide;o-Nitrobenzacetonitrile;o-Nitrobenzyl cyanide;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn; IrritantXi

  • Hazard Codes:Xn,Xi

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH312 Harmful in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. Flash point data for this chemical are not available. It is probably combustible. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:2-Nitrobenzyl Cyanide
  • Packaging:1g
  • Price:$ 312
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:2-Nitrobenzyl Cyanide
  • Packaging:1g
  • Price:$ 50
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Nitrobenzyl Cyanide >98.0%(GC)
  • Packaging:5g
  • Price:$ 88
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Nitrobenzyl Cyanide >98.0%(GC)
  • Packaging:25g
  • Price:$ 304
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Nitrophenylacetonitrile 98%
  • Packaging:10g
  • Price:$ 118
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-(2-Nitrophenyl)acetonitrile 95+%
  • Packaging:25g
  • Price:$ 27
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-(2-Nitrophenyl)acetonitrile 95+%
  • Packaging:100g
  • Price:$ 78
  • Delivery:In stock
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  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:2-Nitrophenylacetonitrile
  • Packaging:10g
  • Price:$ 162
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:2-(2-Nitrophenyl)acetonitrile 98%
  • Packaging:100g
  • Price:$ 111
  • Delivery:In stock
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  • Manufacture/Brand:ChemScene
  • Product Description:2-(2-Nitrophenyl)acetonitrile
  • Packaging:5g
  • Price:$ 79
  • Delivery:In stock
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Relevant articles and documentsAll total 24 Articles be found

Rapid and Simple Access to α-(Hetero)arylacetonitriles from Gem-Difluoroalkenes

Hu, Dandan,Liu, Jiayue,Ren, Hongjun,Song, Jinyu,Zhang, Jun-Qi,Zhu, Guorong

supporting information, p. 786 - 790 (2022/01/28)

A scalable cyanation of gem-difluoroalkenes to (hetero)arylacetonitrile derivatives was developed. This strategy features mild reaction conditions, excellent yields, wide substrate scope, and broad functional group tolerance. Significantly, in this reacti

Substituted conformationally restricted guanidine derivatives: Probing the α2-adrenoceptors’ binding pocket

McMullan, Michela,García-Bea, Aintzane,Miranda-Azpiazu, Patricia,Callado, Luis F.,Rozas, Isabel

, p. 48 - 57 (2016/08/01)

In this paper we report the design, synthesis and pharmacological evaluation of new N-substituted 2-amino-1,4-dihydroquinazolines, 2-amino-1,4-dihydropyridopyrimidines and 2-amino-4,5-dihydro-1,3-benzodiazepines as α2-adrenoceptors ligands. Computational studies show that the proposed substitutions and guanidine-containing ring size will probe an extensive area of the active site. Preparation of these molecules involved novel routes than those previously utilised in our laboratory for the preparation of the acyclic aryl-guanidine counterparts. Compounds 8b and 18c showed the highest affinity and antagonistic activity, within their series, towards the α2-adrenoceptor in human brain tissue in?vitro experiments. Structure-activity relationships have been established for the design and biological evaluation of novel α2-adrenoceptor ligands.

A heterogeneous palladium catalyst hybridised with a titanium dioxide photocatalyst for direct C-C bond formation between an aromatic ring and acetonitrile

Yoshida, Hisao,Fujimura, Yuki,Yuzawa, Hayato,Kumagai, Jun,Yoshida, Tomoko

supporting information, p. 3793 - 3795 (2013/05/22)

A palladium catalyst hybridised with a titanium dioxide photocatalyst can promote cyanomethylation of an aromatic ring by using acetonitrile, where the photocatalyst activates acetonitrile to form a cyanomethyl radical before the C-C bond formation using the palladium catalyst.

Process route upstream and downstream products

Process route

2-hydroxyimino-3-(2-nitro-phenyl)-propionic acid
27878-36-0

2-hydroxyimino-3-(2-nitro-phenyl)-propionic acid

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

Conditions
Conditions Yield
at 160 ℃;
nitro-phenyl-acetic acid amide
861560-54-5

nitro-phenyl-acetic acid amide

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

Conditions
Conditions Yield
With thionyl chloride; durch Behandeln mit Benzol;
With phosphorus pentoxide; durch Destillation;
2-hydroxyimino-3-(2-nitro-phenyl)-propionic acid
27878-36-0

2-hydroxyimino-3-(2-nitro-phenyl)-propionic acid

acetic anhydride
108-24-7

acetic anhydride

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

Conditions
Conditions Yield
phenylacetonitrile
140-29-4

phenylacetonitrile

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

Conditions
Conditions Yield
With nitric acid; acetic acid; at 0 - 40 ℃;
76%
durch Nitrierung;
potassium cyanide
151-50-8

potassium cyanide

2-nitrobenzyl chloride
612-23-7

2-nitrobenzyl chloride

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

Conditions
Conditions Yield
With ethanol; water;
chloroacetonitrile
107-14-2

chloroacetonitrile

nitrobenzene
98-95-3,26969-40-4

nitrobenzene

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

Conditions
Conditions Yield
With potassium tert-butylate; In tetrahydrofuran; at -20 - -10 ℃; for 0.00833333h;
18%
chloroacetonitrile
107-14-2

chloroacetonitrile

nitrobenzene
98-95-3,26969-40-4

nitrobenzene

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

4-Nitrophenylacetonitrile
555-21-5,34512-13-5,174848-08-9

4-Nitrophenylacetonitrile

Conditions
Conditions Yield
With sodium hydroxide; In dimethyl sulfoxide; at 25 ℃; for 1h; Yield given;
With sodium hydroxide; In dimethyl sulfoxide; at 25 ℃; for 1h; Product distribution;
With sodium hydroxide; In dimethyl sulfoxide; at -50 - -30 ℃; for 1h; Yield given;
methylthioacetonitrile
35120-10-6

methylthioacetonitrile

nitrobenzene
98-95-3,26969-40-4

nitrobenzene

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

4-Nitrophenylacetonitrile
555-21-5,34512-13-5,174848-08-9

4-Nitrophenylacetonitrile

Conditions
Conditions Yield
With sodium hydroxide; In dimethyl sulfoxide; at 25 ℃; for 1h; Yield given;
S-(Dimethylthiocarbamoyl)thioglycolonitrile
61540-35-0

S-(Dimethylthiocarbamoyl)thioglycolonitrile

nitrobenzene
98-95-3,26969-40-4

nitrobenzene

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

4-Nitrophenylacetonitrile
555-21-5,34512-13-5,174848-08-9

4-Nitrophenylacetonitrile

Conditions
Conditions Yield
With sodium hydroxide; In dimethyl sulfoxide; at 25 ℃; for 1h; Yield given;
(phenylthio)acetonitrile
5219-61-4

(phenylthio)acetonitrile

nitrobenzene
98-95-3,26969-40-4

nitrobenzene

2-nitro-benzeneacetonitrile
610-66-2

2-nitro-benzeneacetonitrile

4-Nitrophenylacetonitrile
555-21-5,34512-13-5,174848-08-9

4-Nitrophenylacetonitrile

Conditions
Conditions Yield
With sodium hydroxide; In dimethyl sulfoxide; at 30 ℃; for 1.5h;
18%
50 % Chromat.
With sodium hydroxide; In dimethyl sulfoxide; at 25 ℃; for 1h; Yield given;

Global suppliers and manufacturers

Global( 89) Suppliers
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  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:89
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:56
  • Country:China (Mainland)
  • Bluecrystal chem-union
  • Business Type:Trading Company
  • Contact Tel:+86-1895157
  • Emails:bluecrystalchem@163.com
  • Main Products:7
  • Country:China (Mainland)
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