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61072-56-8

61072-56-8

Identification

Synonyms:2-Fluoro-4-chlorobenzaldehyde;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi,Xn

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
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  • Manufacture/Brand:AHH
  • Product Description:4-Chloro-2-fluorobenzaldehyde 98%
  • Packaging:100g
  • Price:$ 466
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:4-Chloro-2-fluorobenzaldehyde
  • Packaging:5g
  • Price:$ 14
  • Delivery:In stock
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:4-Chloro-2-fluorobenzaldehyde, 98%
  • Packaging:10g
  • Price:$ 320
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  • Manufacture/Brand:Alichem
  • Product Description:4-Chloro-2-fluorobenzaldehyde
  • Packaging:250mg
  • Price:$ 470.4
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-FLUORO-4-CHLOROBENZALDEHYDE 95.00%
  • Packaging:5G
  • Price:$ 790.02
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-FLUORO-4-CHLOROBENZALDEHYDE 95.00%
  • Packaging:25G
  • Price:$ 1137.68
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-FLUORO-4-CHLOROBENZALDEHYDE 95.00%
  • Packaging:100G
  • Price:$ 2655.35
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  • Manufacture/Brand:AOBChem
  • Product Description:4-Chloro-2-fluorobenzaldehyde 97%
  • Packaging:50g
  • Price:$ 81
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  • Manufacture/Brand:AOBChem
  • Product Description:4-Chloro-2-fluorobenzaldehyde 97%
  • Packaging:100g
  • Price:$ 130
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  • Manufacture/Brand:Apolloscientific
  • Product Description:4-Chloro-2-fluorobenzaldehyde 97%
  • Packaging:25g
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Relevant articles and documentsAll total 6 Articles be found

TRICYCLIC PIPERIDINE COMPOUNDS

-

, (2016/11/21)

The present invention relates to compounds of the formula (I) wherein R1a, R1b, R2, R3, (R4)n and ring (A) are as described in the description, to their preparation, to pharmaceutically acc

TRICYCLIC PIPERIDINE COMPOUNDS

-

, (2015/06/08)

The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

Enantioselective syntheses of no-carrier-added (n.c.a.) (S)-4-chloro-2-[18F] fluorophenylalanine and (S) - (α-methyl) -4-chloro-2-[18F]fluorophenylalanine

Al-Darwich,Plenevaux,Lemaire,Fiore,Christiaens,Comar,Luxen

, p. 117 - 124 (2007/10/03)

(S)-4-Chloro-2-fluorophenylalanine and (S)-(α-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F]fluorobenzyl iodide and the lithium enolate of (2S)-1-(tert-butyloxycarbonyl)-2-(tert-butyl)-3-methyl-1,3-imidazolidine-4-one for (S)-4-chloro-2-[18F]fluorophenylalanine and (2S,5S)-1-(tert-butyloxycarbonyl)-2-(tert-butyl)-3,5-dimethyl-1,3-imidazolidine-4-one for (S) - (α-methyl)-4-chloro-2-[18F] fluorophenylalanine. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatography (HPLC) purification, with a radiochemical yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F]fluoride. The enantiomeric excesses were shown to be 97% or more for both molecules without chiral separation and the radiochemical and chemical purities were 98% or better.

Process route upstream and downstream products

Process route

2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

2,4-difluorobenzaldehyde
1550-35-2

2,4-difluorobenzaldehyde

2-chloro-4-fluorobenzaldehyde
84194-36-5

2-chloro-4-fluorobenzaldehyde

4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

Conditions
Conditions Yield
With potassium fluoride; In sulfolane; at 220 ℃; for 12h; Product distribution; also with other 1) molar ratios, 2) solvents, 3) temperatures, 4) times;
66%
7%
5%
With potassium fluoride; In sulfolane; at 220 ℃; for 12h;
7%
5%
66%
With potassium fluoride; In sulfolane; at 220 ℃; for 12h; Yield given. Title compound not separated from byproducts;
13%
(4-chloro-2-fluorophenyl)methanol
56456-49-6

(4-chloro-2-fluorophenyl)methanol

4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

Conditions
Conditions Yield
With manganese(IV) oxide; In acetonitrile; for 24h;
With manganese(IV) oxide; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;
With manganese(IV) oxide; In acetonitrile; for 24h;
5-chloro-2-fluorotoluene
452-66-4

5-chloro-2-fluorotoluene

4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

5-chloro-2-fluorobenzaldehyde
96515-79-6

5-chloro-2-fluorobenzaldehyde

Conditions
Conditions Yield
In 4-chloro-2-fluorotoluene;
1-(bromomethyl)-4-chloro-2-fluorobenzene
71916-82-0

1-(bromomethyl)-4-chloro-2-fluorobenzene

4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

Conditions
Conditions Yield
With hexamethylenetetramine; In acetic acid; for 4h; Heating;
60%
4-chloro-2-fluorobenzoic acid
446-30-0

4-chloro-2-fluorobenzoic acid

4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 °C
2: manganese(IV) oxide / acetonitrile / 24 h
With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; acetonitrile;
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 °C / Inert atmosphere
2: manganese(IV) oxide / acetonitrile / 24 h / 20 °C / Inert atmosphere
With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; acetonitrile;
4-chloro-2-fluorotoluene
452-75-5

4-chloro-2-fluorotoluene

4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 65 percent / NBS, benzoyl peroxide / CCl4 / Heating
2: 60 percent / HMTA / aq. acetic acid / 4 h / Heating
With N-Bromosuccinimide; Perbenzoic acid; hexamethylenetetramine; In tetrachloromethane; acetic acid;
4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

sodium methylate
124-41-4

sodium methylate

4-chloro-2-methoxybenzaldehyde
53581-86-5

4-chloro-2-methoxybenzaldehyde

Conditions
Conditions Yield
With methanol; at 50 ℃; for 3h;
77.5%
In methanol; Reflux;
4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

8-oxa-3-azabicyclo[3.2.1]octane hydrochloride
54745-74-3

8-oxa-3-azabicyclo[3.2.1]octane hydrochloride

2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-4-chlorobenzaldehyde

2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-4-chlorobenzaldehyde

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl acetamide; at 140 ℃;
71%
4-fluoropiperidine
78197-27-0

4-fluoropiperidine

4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

4-chloro-2-(4-fluoropiperidin-1-yl)benzaldehyde

4-chloro-2-(4-fluoropiperidin-1-yl)benzaldehyde

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl acetamide; at 140 ℃; for 24h;
67%
8-oxa-3-aza-bicyclo[3.2.1]octane
280-13-7

8-oxa-3-aza-bicyclo[3.2.1]octane

4-chloro-2-fluorobenzaldehyde
61072-56-8

4-chloro-2-fluorobenzaldehyde

2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-4-chlorobenzaldehyde

2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-4-chlorobenzaldehyde

Conditions
Conditions Yield
With potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 4h;
43%

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