61072-56-8

Basic information

• Product Name: 4-CHLORO-2-FLUOROBENZALDEHYDE
• Synonyms: 4-Chloro-2-fluorobenzaldehyde,99%;3-Fluoro-4-formylchlorobenzene;2-fluoro-4-chlorobenzene Methylal;4-Chloro-2-fluorobenzaldehyde, 99% 5GR;4-CHLORO-2-FLUOROBENZALDEHYDE;2-FLUORO-4-CHLOROBENZALDEHYDE;TIMTEC-BB SBB003985;4-Chloro-2-Fluorobenzaldehyde 2-Fluoro-4-Chlorobenzaldehyde
• CAS NO: 61072-56-8
• Molecular Formula: C₇H₄ClFO
• Molecular Weight: 158.56
• EINECS: -0
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Adehydes, Acetals & Ketones;Chlorine Compounds;Fluorine Compounds
• Mol File: 61072-56-8.mol

Chemical Properties

• Melting Point: 58-61 °C
• Boiling Point: 118-120 C
• Flash Point: 80.69 °C
• Appearance: White to yellow-beigeor/Crystals or Powder
• Density: 1.3310 (estimate)
• Vapor Pressure: 0.199mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Refrigerator
• Water Solubility: Insoluble
• Sensitive: Air Sensitive
• BRN: 3537705
• CAS DataBase Reference: 4-CHLORO-2-FLUOROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-FLUOROBENZALDEHYDE(61072-56-8)
• EPA Substance Registry System: 4-CHLORO-2-FLUOROBENZALDEHYDE(61072-56-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 37/39-26-36-37
• TSCA: T
• HazardClass: IRRITANT, AIR SENSITIVE
• Hazardous Substances Data: 61072-56-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-fluorobenzaldehyde is used as a pharmaceutical intermediate for the synthesis of various drugs and pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new medications, particularly those targeting specific biological pathways or receptors.
Used in Chemical Synthesis:
In addition to its pharmaceutical applications, 4-chloro-2-fluorobenzaldehyde is also utilized in the chemical synthesis of various organic compounds. Its reactivity and stability make it a valuable precursor for the production of dyes, pigments, and other specialty chemicals.
Used in Research and Development:
Due to its unique chemical properties, 4-chloro-2-fluorobenzaldehyde is often employed in research and development settings. Scientists and researchers use this compound to study its reactivity, explore new synthetic routes, and develop novel applications in various fields, including materials science, pharmaceuticals, and agrochemicals.

InChI:InChI=1/C7H4ClFO/c8-6-2-1-5(4-10)7(9)3-6/h1-4H

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 71916-82-0 1-(bromomethyl)-4-chloro-2-fluorobenzene 
• 452-75-5 4-chloro-2-fluorotoluene 
• 446-30-0 4-chloro-2-fluorobenzoic acid 
• 56456-49-6 (4-chloro-2-fluorophenyl)methanol 
• 452-66-4 5-chloro-2-fluorotoluene 

Downstream Products

• 87073-75-4 4-Chloro-2-dimethylaminobenzaldehyde 
• 803732-73-2 4-(4-chloro-2-fluoro-phenyl)-4-hydroxy-but-2-ynoic acid ethyl ester 
• 56456-49-6 (4-chloro-2-fluorophenyl)methanol 
• 1008562-79-5 4-chloro-2-(2-fluoro-6-methoxy-phenoxy)-benzaldehyde 
• 104795-85-9 methyl 6-chlorobenzo[b]thiophene-2-carboxylate 
• 536761-10-1 N-(4-chloro-2-fluoro-benzyl)phthalimide 
• 900505-17-1 4-(4-chloro-2-fluoro-benzyl)-3-(4-chloro-phenyl)-7-iodo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 72235-57-5 (4-chloro-2-fluorophenyl)methanamine 
• 753926-01-1 (4-chloro-2-fluoro-phenyl)-(1-isobutyl-1H-indazol-5-yl)-methanol 
• 847350-58-7 4-chloro-2-(2-fluoro-phenoxy)-benzaldehyde 
• 864082-28-0 methyl 4-(4-chloro-2-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate 
• 897652-05-0 (4-chloro-2-fluoro-phenyl)-trimethylsilanyloxyacetonitrile 
• 874120-06-6 methyl 4-(4-chloro-2-fluorophenyl)-6-methyl-2-[4-(methyloxy)phenyl]-1,4-dihydro-5-pyrimidinecarboxylate 
• 190130-64-4 4-chloro-2-fluorobenzaldehyde (N-methyl)hydrazone 

Relevant articles and documents

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I) wherein R1a, R1b, R2, R3, (R4)n and ring (A) are as described in the description, to their preparation, to pharmaceutically acc

TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE

The present invention relates to compounds of the formula (I), wherein R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to thei

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

Heterocyclic pesticidal compounds

Compounds of the formula (I) STR1 which contain between 10 and 27 carbon atoms, and wherein m and n are independently selected from 0, 1 and 2; R2a is hydrogen, methyl, or ethyl; R2b is acetylene or contains between 3 and 18 carbon atoms and is a group R7, wherein R7 is a C1-13 non-aromatic hydrocarbyl group, optionally substituted by a cyano or C1-4 carbalkoxy group and/or by one or two hydroxy groups and/or by one to five halo atoms which are the same or different and/or by one to three groups R8 which are the same or different and each contain one to four hetero atoms, which are the same or different and are chosen from oxygen, sulphur, nitrogen and silicon, 1 to 10 carbon atoms and optionally 1 to 6 fluoro or chloro atoms or R2b is a 6-membered aromatic ring substituted by cyano and/or by one to three groups R8 and/or by a group --C CH, --C C-R7 or C C-halo and/or by one to five halo atoms and/or by one to three C1-4 haloalkyl groups wherein R7 and R8 are as hereinbefore defined; R4 and R6 are the same or different and are chosen from hydrogen, methyl, trifluoromethyl or cyano; and R5 is hydrogen or methyl provided that R2b is not propyl or butyl are described which have pesticidal activity, particularly against arthropod pests. Pesticidal formulations containing the compounds of the formula (I), their use in the control of pests and method for their preparation are also disclosed.

Enantioselective syntheses of no-carrier-added (n.c.a.) (S)-4-chloro-2-[18F] fluorophenylalanine and (S) - (α-methyl) -4-chloro-2-[18F]fluorophenylalanine

(S)-4-Chloro-2-fluorophenylalanine and (S)-(α-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F]fluorobenzyl iodide and the lithium enolate of (2S)-1-(tert-butyloxycarbonyl)-2-(tert-butyl)-3-methyl-1,3-imidazolidine-4-one for (S)-4-chloro-2-[18F]fluorophenylalanine and (2S,5S)-1-(tert-butyloxycarbonyl)-2-(tert-butyl)-3,5-dimethyl-1,3-imidazolidine-4-one for (S) - (α-methyl)-4-chloro-2-[18F] fluorophenylalanine. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatography (HPLC) purification, with a radiochemical yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F]fluoride. The enantiomeric excesses were shown to be 97% or more for both molecules without chiral separation and the radiochemical and chemical purities were 98% or better.

'HALEX' FLUORINATION OF CHLORINATED BENZALDEHYDES AND BENZOYL CHLORIDES

Spray-dried potassium fluoride, suspended in sulpholane at 220 degC, converted 2,4- and 2,6-dichlorobenzaldehyde into the corresponding difluoroaldehydes (yields ca. 65percent).Small amounts of the mono-substituted products (2-chloro-4-fluoro- + 4-chloro-2-fluorobenzaldehyde, and 2-chloro-6-fluoro-benzaldehyde, respectively) were also produced.Similar treatment of the 3,4-dichloro-analogue gave 3-chloro-4-fluorobenzaldehyde (yield 98percent, conversion 68percent), but 2- and 4-chlorobenzaldehyde gave very poor yields (ca. 5percent) of the 2- and 4-fluoro-derivatives. 2-Fluoro-, 4-fluoro- and 3-chloro-4-fluorobenzoyl fluoride were obtained (yields 60-65percent) by heating the corresponding chlorobenzoyl chlorides with potassium fluoride in sulpholane.