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61553-71-7

61553-71-7

Identification

Synonyms:Imidazolinon;imidazolin-5-one;3,5-Dihydro-4H-imidazol-4-one;2,9-dihydro-2,4,9-triaza-fluoren-1-one;3,5-Dihydro-imidazol-4-on;Imidazolone;2-imidazolin-5-one;imidazol-4-one;3,5-dihydro-imidazol-4-one;4-imidazolone;3H-4-Oxo-pyrimido<5,6-b>indol;5H-pyrimido<5,4-b>indole-4-one;IMIDAZOLINONE;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:3H-Pyrimido[5,4-b]indol-4(5H)-one
  • Packaging:10mg
  • Price:$ 45
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:3H-Pyrimido[5,4-b]indol-4(5H)-one
  • Packaging:50mg
  • Price:$ 65
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3,5-Dihydro-4H-pyrimido[5,4-b]indol-4-one
  • Packaging:0.500g
  • Price:$ 240
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3,5-Dihydro-4H-pyrimido[5,4-b]indol-4-one
  • Packaging:1g
  • Price:$ 300
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:3H-Pyrimido[5,4-b]indol-4(5H)-one 95+%
  • Packaging:25g
  • Price:$ 2723
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:3H-Pyrimido[5,4-b]indol-4(5H)-one 95+%
  • Packaging:10g
  • Price:$ 1123
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  • Manufacture/Brand:Crysdot
  • Product Description:3H-Pyrimido[5,4-b]indol-4(5H)-one 95+%
  • Packaging:5g
  • Price:$ 588
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:3,5-Dihydro-4H-pyrimido[5,4-b]indol-4-one
  • Packaging:1 g
  • Price:$ 255
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:3,5-Dihydro-4H-pyrimido[5,4-b]indol-4-one
  • Packaging:500 mg
  • Price:$ 150
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:3,5-Dihydro-4H-pyrimido[5,4-b]indol-4-one
  • Packaging:2 g
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Relevant articles and documentsAll total 4 Articles be found

9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein

Stefan, Katja,Schmitt, Sven Marcel,Wiese, Michael

, p. 8758 - 8780 (2017/11/15)

P-Glycoprotein (P-gp, ABCB1), multidrug resistance-associated protein 1 (MRP1, ABCC1), and breast cancer resistance protein (BCRP, ABCG2) are the three major ABC transport proteins conferring resistance to many structurally diverse anticancer agents, lead

Synthesis of 4-hydrazino-5H-pyrimido[5,4-b]indole and related compounds

Monge,Palop,Goni,et al.

, p. 647 - 649 (2007/10/02)

-

Process route upstream and downstream products

Process route

3-(dimethylamino-methyleneamino)-1H-indole-2-carboxylic acid ethyl ester
97311-03-0

3-(dimethylamino-methyleneamino)-1H-indole-2-carboxylic acid ethyl ester

5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

Conditions
Conditions Yield
With ammonia; In ethanol; at 60 - 70 ℃; for 3h;
79%
3-(dimethylamino-methyleneamino)-1H-indole-2-carboxylic acid ethyl ester; With ammonia; In ethanol; at 0 - 110 ℃;
With sodium hydroxide; In water; for 0.5h;
With acetic acid; In water; pH=7;
ethyl 3-amino-1H-indole-2-carboxylate
87223-77-6

ethyl 3-amino-1H-indole-2-carboxylate

5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

Conditions
Conditions Yield
In formamide; at 220 ℃; for 2h;
80%
Multi-step reaction with 2 steps
1.1: DMF (N,N-dimethyl-formamide) / 100 °C
2.1: ammonia / ethanol / 0 - 110 °C
2.2: 0.5 h
2.3: pH 7
With ammonia; In DMF (N,N-dimethyl-formamide); ethanol;
anthranilic acid nitrile
1885-29-6

anthranilic acid nitrile

5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: 2 h / 100 °C / Microwave irradiation
2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C
3: N,N-dimethyl-formamide / 5 h / 100 °C
4: ammonia / ethanol / 5 h / Reflux
With ammonia; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
2-acetamidobenzonitrile
25116-00-1

2-acetamidobenzonitrile

5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C
2: N,N-dimethyl-formamide / 5 h / 100 °C
3: ammonia / ethanol / 5 h / Reflux
With ammonia; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
ethyl 1-acetyl-3-amino-1H-indole-2-carboxylate

ethyl 1-acetyl-3-amino-1H-indole-2-carboxylate

5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 5 h / 100 °C
2: ammonia / ethanol / 5 h / Reflux
With ammonia; In ethanol; N,N-dimethyl-formamide;
ethyl 1-acetyl-3-(((dimethylamino)methylene)amino)-1H-indole-2-carboxylate

ethyl 1-acetyl-3-(((dimethylamino)methylene)amino)-1H-indole-2-carboxylate

5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

Conditions
Conditions Yield
With ammonia; In ethanol; for 5h; Reflux;
5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

Conditions
Conditions Yield
2-Ethoxycarbonyl-3-acetylaminoindol, Formamid, Δ (3h);
5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

benzyl-(1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9H-2,4,9-triaza-fluoren-6-yl)-amine

benzyl-(1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9H-2,4,9-triaza-fluoren-6-yl)-amine

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: triethylamine hydrochloride; trichlorophosphate / 18 h / Heating / reflux
2.1: sodium nitrate; sulfuric acid / water / 0 - 20 °C
3.1: triethylamine / DMF (N,N-dimethyl-formamide) / 80 °C
4.1: hydrogen / palladium on activated charcoal / methanol; dichloromethane / 16 h
5.1: methanol / 0.5 h / 20 °C
5.2: 3 h
With sodium nitrate; sulfuric acid; hydrogen; triethylamine hydrochloride; triethylamine; trichlorophosphate; palladium on activated charcoal; In methanol; DMF (N,N-dimethyl-formamide); dichloromethane; water;
5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

4-chloro-N-(1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9H-2,4,9-triaza-fluoren-6-yl)-benzamide

4-chloro-N-(1-{4-[2-(3,4-difluoro-phenyl)ethyl]-piperazin-1-yl}-9H-2,4,9-triaza-fluoren-6-yl)-benzamide

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: triethylamine hydrochloride; trichlorophosphate / 18 h / Heating / reflux
2: sodium nitrate; sulfuric acid / water / 0 - 20 °C
3: triethylamine / DMF (N,N-dimethyl-formamide) / 80 °C
4: hydrogen / palladium on activated charcoal / methanol; dichloromethane / 16 h
5: pyridine / 50 °C
With pyridine; sodium nitrate; sulfuric acid; hydrogen; triethylamine hydrochloride; triethylamine; trichlorophosphate; palladium on activated charcoal; In methanol; DMF (N,N-dimethyl-formamide); dichloromethane; water;
5H-pyrimido<5,4-b>indole-4-one
61553-71-7

5H-pyrimido<5,4-b>indole-4-one

1-{4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl}-9H-2,4,9-triazafluoren-6-ylamine
676601-64-2

1-{4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl}-9H-2,4,9-triazafluoren-6-ylamine

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: triethylamine hydrochloride; trichlorophosphate / 18 h / Heating / reflux
2: sodium nitrate; sulfuric acid / water / 0 - 20 °C
3: triethylamine / DMF (N,N-dimethyl-formamide) / 80 °C
4: hydrogen / palladium on activated charcoal / methanol; dichloromethane / 16 h
With sodium nitrate; sulfuric acid; hydrogen; triethylamine hydrochloride; triethylamine; trichlorophosphate; palladium on activated charcoal; In methanol; DMF (N,N-dimethyl-formamide); dichloromethane; water;

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