25116-00-1

Basic information

• Product Name: N-(2-cyanophenyl)acetamide
• Synonyms: 2-Acetamidobenzonitrile;2-(Acetylamino)benzonitrile;2'-Cyanoacetoanilide;Nsc73082
• CAS NO: 25116-00-1
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.18
• Product Categories: Anilines, Amides & Amines;Nitriles
• Mol File: 25116-00-1.mol
• Article Data: 24

Chemical Properties

• Melting Point: 92 °C
• Boiling Point: 389.1 °C at 760 mmHg
• Flash Point: 189.1 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 2.92E-06mmHg at 25°C
• Refractive Index: 1.557
• PKA: 14.03±0.70(Predicted)
• CAS DataBase Reference: N-(2-cyanophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-cyanophenyl)acetamide(25116-00-1)
• EPA Substance Registry System: N-(2-cyanophenyl)acetamide(25116-00-1)

Safety Data

• Hazardous Substances Data: 25116-00-1(Hazardous Substances Data)

Usage

General Description

N-(2-cyanophenyl)acetamide is a chemical compound with the molecular formula C10H9N3O. It is an amide derivative of 2-phenylacetic acid and is commonly used in organic synthesis and pharmaceutical research. N-(2-cyanophenyl)acetamide is a white to off-white crystalline solid that is relatively stable under normal conditions. N-(2-cyanophenyl)acetamide has been studied for its potential antimicrobial and anti-inflammatory properties, and it is also used as a building block in the synthesis of various pharmaceutical compounds. Its structure and properties make it a valuable component in the development of new drugs and chemical compounds.

InChI:InChI=1/C9H8N2O/c1-7(12)11-9-5-3-2-4-8(9)6-10/h2-5H,1H3,(H,11,12)

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 127-19-5 N,N-dimethyl acetamide 
• 98952-93-3 2-acetylamino-benzaldehyde-oxime 
• 612-24-8 o-nitrobenzonitrile 
• 108-24-7 acetic anhydride 
• 81431-98-3 2-cyanophenylisothiocyanate 
• 75-05-8 acetonitrile 
• 71-43-2 benzene 
• 118134-11-5 5-(o-acetamidophenyl)-1,3,4-oxathiazol-2-one 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 33809-77-7 2-acetamidobenzamide 
• 2757-23-5 chloro(chlorosulfanyl)methanone 
• 614-76-6 N-acetyl-2-bromoaniline 
• 103-84-4 Acetanilid 

Downstream Products

• 61553-71-7 5H-pyrimido<5,4-b>indole-4-one 
• 98792-02-0 4-chloro-5H-pyrimido<5,4-b>indole 
• 320420-18-6 (4-phenylpiperazin-1-yl)-5H-pyrimido[5,4-b]indole 
• 61453-53-0 2-methyl-4-phenylquinazoline 
• 33809-77-7 2-acetamidobenzamide 
• 1789-09-9 1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-4-hydroxybenzene 
• 1769-24-0 2-methyl-4-quinazolone 
• 30507-16-5 3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one 

Relevant articles and documents

KOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines

This work discloses transamidation of primary and tertiary amides with a range of aryl, heteroaryl, and aliphatic amines using potassium tert-butoxide. The reaction proceeds at room temperature under transition-metal-free conditions providing secondary amides in high yields. Moreover, reaction of cyclopropyl amine with tertiary amides proceeds with ring-opening to provide a rapid access to enamides.

Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines

The synthesis of 2,4-disubstituted quinazolines by a palladium-catalyzed reaction of arylboronic acids with N-(2-cyanoaryl)benzamides has been developed with moderate to excellent yields. The method shows good functional group tolerance. In particular, ha

Synthesis of 2-methylbenzoxazoles directly from: N -phenylacetamides catalyzed by palladium acetate

A method to synthesize 2-methylbenzoxazoles directly from N-phenylacetamides catalyzed by Pd(OAc)2 in the presence of K2S2O8 and TfOH has been developed. The desired products were obtained in moderate to excellent yields. This approach provides a facile procedure to prepare benzoxazoles with available substrates. It is found that TfOH is the key factor for this cyclization reaction. A plausible mechanism of the reaction is proposed according to the control reactions and the literature.