616-30-8

Basic information

• Product Name: 3-Amino-1,2-propanediol
• Synonyms: 1,2-Propanediol, 3-amino-;1-aminopropanediol;2,3-Dihydroxypropylamine;2,3-Propandiol-1-amine;3-amino-2-propanediol;3-AMINO-1,2-DIHYDROXYPROPANE;3-AMINO-1,2-PROPANDIOL;(+/-)-3-AMINO-1,2-PROPANEDIOL
• CAS NO: 616-30-8
• Molecular Formula: C₃H₉NO₂
• Molecular Weight: 91.11
• EINECS: 210-475-8
• Product Categories: Alcohols and Derivatives;API;Amino Alcohols;Organic Building Blocks;Oxygen Compounds
• Mol File: 616-30-8.mol

Chemical Properties

• Melting Point: 55-57 °C
• Boiling Point: 264-265 °C739 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to pale yellow/liquid (highly viscous)
• Density: 1.175 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00116mmHg at 25°C
• Refractive Index: n20/D 1.492(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: >1000g/l soluble
• PKA: 12.11±0.35(Predicted)
• Water Solubility: soluble
• Sensitive: Hygroscopic
• BRN: 1719121
• CAS DataBase Reference: 3-Amino-1,2-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-1,2-propanediol(616-30-8)
• EPA Substance Registry System: 3-Amino-1,2-propanediol(616-30-8)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39-45-36
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 2
• RTECS: TY2800000
• F: 10-21
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 616-30-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-1,2-propanediol is used as a calcium metabolism regulator for the treatment of [application reason] Paget's disease, tumor-induced hypercalcemia, and other bone disorders involving increased osteoclastic activity.
Used in Medical Imaging:
3-Amino-1,2-propanediol is used as a starting material in the preparation of iohexol, which is a X-CT non-ionic contrast medium for [application reason] enhancing the visualization of internal body structures during X-ray computed tomography (CT) scans.
Used in Specialty Materials Production:
3-Amino-1,2-propanediol is used as a starting material in the production of [application type] specialty materials for [application reason] various industrial applications due to their unique properties.
Used in RNA Interference Therapeutics:
(±)-3-Amino-1,2-propanediol is used as a reactant in the synthesis of lipid-like delivery molecules (lipidoids) for [application type] RNA interference (RNAi) therapeutics for [application reason] developing treatments that can effectively silence specific genes to combat diseases.
Used in Gene Delivery:
3-Amino-1,2-propanediol is used in the synthesis of the bioactive template to prepare cationic α-helical polypeptides and various cationic polymers for [application type] gene delivery for [application reason] facilitating the delivery of genetic material into cells for therapeutic purposes.

Originator

Henkel (W. Germany)

Preparation

3-Amino-1,2-propanediol is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with ammonia in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps.

InChI:InChI=1/C3H9NO2/c4-1-3(6)2-5/h3,5-6H,1-2,4H2/p+1/t3-/m1/s1

Upstream product

• 93372-65-7 2-hydroxy-3-methoxypropylamine 
• 818-63-3 N-(2,3-dibromo-propyl)-acetamide 
• 556-52-5 oxiranyl-methanol 
• 96-24-2 3-monochloro-1,2-propanediol 
• 7664-41-7 ammonia 
• 7732-18-5 water 
• 62037-46-1 rac-1-amino-3-chloro-2-propanol hydrochloride 
• 56-82-6 Glyceraldehyde 
• 22195-47-7 4-aminomethyl-2,2-dimethyl[1,3]dioxolane 

Downstream Products

• 62457-35-6 2-(2,3-dihydroxypropyl)isoindoline-1,3-dione 
• 56-81-5 glycerol 
• 19737-19-0 3-(ethylamino)-1,2-propanediol 
• 70133-12-9 3-(4-nitro-anilino)-propane-1,2-diol 
• 858009-93-5 3-(4,5-dimethyl-2-nitro-anilino)-propane-1,2-diol 
• 78213-38-4 3-(5-chloro-2-nitro-anilino)-propane-1,2-diol 
• 100132-79-4 N-(2,3-dihydroxy-propyl)-toluene-4-sulfonamide 
• 209531-97-5 N-(2,3-dihydroxypropyl)octadecanamide 
• 90559-79-8 3-(2,4-dinitro-anilino)-propane-1,2-diol 
• 33372-40-6 4-(2,3-Dihydroxypropylamino)-2-(5-nitro-2-thienyl)-chinazolin 
• 90648-98-9 p-(2,3-Dihydroxypropylsulfamoyl)benzolsulfonamid 
• 34450-03-8 C₂₃H₂₁N₅O₈ 
• 34450-02-7 C₂₇H₂₁N₅O₁₁ 
• 4220-30-8 3,3'-[(2,3-dihydroxypropyl)imino]bispropiononitrile 

Relevant articles and documents

COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED FROM A DIASTEREOISOMERICALLY ENRICHED PCTA AND PREPARATION AND PURIFICATION PROCESS

The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.

PROCESS FOR THE HYDROLYSIS OR ALCOHOLYSIS OF CYCLIC KETAL OR ACETAL GROUPS WITH CARBON DIOXIDE OR AN ALCOHOL

Process for the hydrolysis or alcoholysis of a ketal or acetal compound wherein a ketal or acetal compound comprising at least one ketal or acetal group and at least one amino group is reacted with carbon dioxide and water oran alcohol.

PROCESS FOR THE PREPARATION OF A 3-AMINO-1,2-PROPANDIOL AND DERIVATIVES THEREOF

Process for the preparation of a compound of formula (I) with R1 and R2 independently from each other representing hydrogen or a C1-to C10 alkyl group by a two-step process wherein the first step is an amination of the compound of formula (II) with an amino compound HNR1 R2 in the presence of hydrogen and resulting in the compound of formula (III) and the second step is a ring-cleaving of the compound of formula (III) giving the compound of formula (I).

Production of Primary Amines by Reductive Amination of Biomass-Derived Aldehydes/Ketones

Transformation of biomass into valuable nitrogen-containing compounds is highly desired, yet limited success has been achieved. Here we report an efficient catalyst system, partially reduced Ru/ZrO2, which could catalyze the reductive amination of a variety of biomass-derived aldehydes/ketones in aqueous ammonia. With this approach, a spectrum of renewable primary amines was produced in good to excellent yields. Moreover, we have demonstrated a two-step approach for production of ethanolamine, a large-market nitrogen-containing chemical, from lignocellulose in an overall yield of 10 %. Extensive characterizations showed that Ru/ZrO2-containing multivalence Ru association species worked as a bifunctional catalyst, with RuO2 as acidic promoter to facilitate the activation of carbonyl groups and Ru as active sites for the subsequent imine hydrogenation.

Method for preparing polyamine by direct ammoniation of polyhydroxy compound

A method for preparing polyamine by direct ammoniation of a polyhydroxy compound is disclosed. By using a polyhydroxy compound, ammonia gas or liquefied ammonia as a raw material and using a carrier-loaded liquid-phase reduced transition metal as a catalyst, an ammoniation reaction of the polyhydroxy compound under mild conditions is realized. The catalyst has high selectivity of polyamine. The catalyst can be recovered and recycled.

A process for the preparation of amino-glycerol

The invention belongs to the chemical field, particularly relates to a production and synthesis technology of a medical intermediate, and provides a preparation method of 3-amino-1,2-propanediol mainly aiming at a 3-amino-1,2-propanediol product. The preparation method of 3-amino-1,2-propanediol adopts epichlorohydrin and ammonia water as the main raw materials, a two-component catalyst is used in a hydrolysis reaction process and an ammoniation reaction process respectively, the reaction temperature in earlier period and later period in a hydrolysis reaction kettle is increased in a segmented manner, the reaction selectivity is improved, side effects are reduced, the reaction rate is increased, the reaction time is shortened, and energy consumption is reduced. The specific operation flow of the preparation method comprises the hydrolysis reaction, neutralization, distillation, ammoniation reaction, filtering, distillation, centrifugation and rectification. Meanwhile, the catalyst can be recycled and the cost can be saved, and the preparation method further has the advantages of high safety, stable product quality, high purity and the like.

PROCESS FOR THE PRODUCTION OF AMINO ALCOHOLS

The present invention relates to a process for the manufacture of APD and N-alkyl-APD wherein 1-CPD is reacted with aqueous ammonium or aqueous alkyl-amine under alkaline conditions and where the process is conducted in a continuous manner in a reactor comprising a tubular reactor wherein at least two reaction zones are established.

Pyrazolopyrimidines as therapeutic agents

The present invention is directed to pyrazolopyrimidine derivatives of formula (I) wherein the substituents are defined herein, which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.

A process for the prepration of a dihydroxyamino compound

Disclosed are a process for the preparation of a dihydroxyamino compound in which water and discoloring ingredients are removed while preventing decomposition of a dihydroxyamino compound by distilling a crude reaction liquid containing an epoxy compound and an amino compound at a specified temperature and pressure, a process for improving a yield of a dihydroxyamino compound having high purity by recirculating an aqueous solution of an amino compound recollected from a crude reaction liquid into a reaction step, and a process in which there are prevented discoloration and a yield decline of a dihydroxyamino compound.

Process for the preparation of n,n'-bis[2,3-dihydroxypropyl]-5-[(hydroxyacetyl) methylamino]-2, 4,6-triiodo-1, 3-benzenedi carboxamide

A novel process for the preparation of N,N′-bis[2,3-dihydroxypropyl]-5-[(hydroxyacetyl) methylamino]-2,4,6-triiodo-1, 3-benzenedi carboxamide of formula (I), commonly known as lomeprol, a novel non-ionic contrast agent which shows very good safety and contrast effectiveness.