93372-65-7

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 4404, 1951 DOI: 10.1021/ja01153a107

InChI:InChI=1/C4H11NO2/c1-7-3-4(6)2-5/h4,6H,2-3,5H2,1H3

Upstream product

• 168431-71-8 1-azido-3-methoxypropan-2-ol 
• 930-37-0 glycidyl methyl ether 

Downstream Products

• 67-63-0 isopropyl alcohol 
• 229342-11-4 N-(5-chloropyridin-2-yl)-2-[((4-((2-imino-5-(methoxymethyl)oxazolidin-3-yl)methyl)-3-chlorothiophen-2-yl)carbonyl)amino]-3-methoxy-5-chlorobenzamide, trifluoroacetic acid salt 
• 135205-35-5 rac-benzyl (2-hydroxy-3-methoxypropyl)carbamate 
• 1300100-71-3 C₂₁H₃₁F₂N₃O₄ 
• 1186528-70-0 C₁₁H₁₆FNO₂ 
• 1186057-87-3 5,5'-(2-hydroxypropane-1,3-diyl)bis(acetylazanediyl)bis(N₁,N₃-bis(2-hydroxy-3-methoxypropyl)-2,4,6-triiodoisophthalamide) 
• 857944-93-5 2-acetoxy-1-acetylamino-3-methoxy-propane 
• 616-30-8 3-Amino-1,2-propanediol 

Relevant academic research and scientific papers

Reinventing Design Principles for Developing Low-Viscosity Carbon Dioxide-Binding Organic Liquids for Flue Gas Clean Up

Anthropogenic CO2emissions from point sources (e.g., coal fired-power plants) account for the majority of the greenhouse gases in the atmosphere. Water-lean solvent systems such as CO2-binding organic liquids (CO2BOLs) are being developed to reduce the energy requirement for CO2capture. Many water-lean solvents such as CO2BOLs are currently limited by the high viscosities of concentrated electrolyte solvents, thus many of these solvents have yet to move toward commercialization. Conventional standard trial-and-error approaches for viscosity reduction, while effective, are time consuming and economically expensive. We rethink the metrics and design principles of low-viscosity CO2-capture solvents using a combined synthesis and computational modeling approach. We critically study the effects of viscosity reducing factors such as orientation of hydrogen bonding, introduction of higher degrees of freedom, and cation or anion charge solvation, and assess whether or how each factor affects viscosity of CO2BOL CO2capture solvents. Ultimately, we found that hydrogen bond orientation and strength is the predominant factor influencing the viscosity in CO2BOL solvents. With this knowledge, a new CO2BOL variant, 1-MEIPADM-2-BOL, was synthesized and tested, resulting in a solvent that is approximately 60 % less viscous at 25 mol % CO2loading than our base compound 1-IPADM-2-BOL. The insights gained from the current study redefine the fundamental concepts and understanding of what influences viscosity in concentrated organic CO2-capture solvents.

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF

The present invention relates to a benzodiazepine derivative of Formula I as a short-acting anesthetic, a pharmaceutical composition comprising the same, a kit comprising the same, a preparation method thereof, an method of anesthesia using the same and use thereof in the manufacture of an anesthetic medicament.