62013-44-9

Basic information

• Product Name: methyl 2-nitro-propionate
• CAS NO: 62013-44-9
• Molecular Weight: 133.104
• Mol File: 62013-44-9.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-nitro-propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-nitro-propionate(62013-44-9)
• EPA Substance Registry System: methyl 2-nitro-propionate(62013-44-9)

Safety Data

• Hazardous Substances Data: 62013-44-9(Hazardous Substances Data)

Upstream product

• 5445-17-0 Methyl 2-bromopropionate 
• 2483-57-0 methyl 2-nitroacetate 
• 74-88-4 methyl iodide 
• 61985-23-7 methyl 1-imidazolecarboxylate 
• 79-24-3 Nitroethane 
• 79-22-1 methyl chloroformate 
• 65397-15-1 sodium methoxycarbonylmethane nitronate 
• 67-56-1 methanol 
• 124-38-9 carbon dioxide 

Downstream Products

• 1589528-69-7 (E)-methyl 2-methyl-2-nitro-5-phenylpent-4-enoate 
• 1430818-88-4 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(3-bromophenyl)-2-methyl-2-nitropropanoate 
• 1430818-87-3 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(3-chlorophenyl)-2-methyl-2-nitropropanoate 
• 1430818-86-2 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(3-fluorophenyl)-2-methyl-2-nitropropanoate 
• 1430818-85-1 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(2-bromophenyl)-2-methyl-2-nitropropanoate 
• 1430818-84-0 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(2-fluorophenyl)-2-methyl-2-nitropropanoate 
• 1430818-73-7 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-2-methyl-2-nitro-3-phenylpropanoate 
• 1430818-93-1 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-2-methyl-2-nitro-3-(m-tolyl)propanoate 
• 1430818-92-0 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-2-methyl-2-nitro-3-(p-tolyl)propanoate 
• 1430818-91-9 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(4-bromophenyl)-2-methyl-2-nitropropanoate 
• 1430818-90-8 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(4-chlorophenyl)-2-methyl-2-nitropropanoate 
• 1430818-89-5 methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(4-fluorophenyl)-2-methyl-2-nitropropanoate 
• 1088705-76-3 C₁₇H₂₄N₂O₆ 

Relevant articles and documents

Inclusion complexes of EMPO derivatives with 2,6-di-O-methyl-β- cyclodextrin: Synthesis, NMR and EPR investigations for enhanced superoxide detection

The free radical trapping properties of eight 5-alkoxycarbonyl-5-methyl-1- pyrroline N-oxide (EMPO) type nitrones and those of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) were evaluated for trapping of superoxide anion radicals in the presence of 2,6-di-O-methyl-β-cyclodextrin (DM-β-CD). 1H-NMR titrations were performed to determine both stoichiometries and binding constants for the diamagnetic nitrone-DM-β-CD equilibria. EPR titrations were then performed and analyzed using a two-dimensional EPR simulation program affording 1: 1 and 1: 2 stoichiometries for the nitroxide spin adducts with DM-β-CD and the associated binding constants after spin trapping. The nitroxide spin adducts associate more strongly with DM-β-CD than the nitrones. The ability of the nitrones to trap superoxide, the enhancement of the EPR signal intensity and the supramolecular protection by DM-β-CD against sodium l-ascorbate reduction were evaluated. The Royal Society of Chemistry 2006.

A Facile Synthesis of α-Amino Esters via Reduction of α-Nitro Esters Using Ammonium Formate as a Catalytic Hydrogen Transfer Agent

Various nitroesters 3 were selectively and rapidly reduced to their corresponding amino esters 4 in very good yield using anhydrous ammonium formate as a catalytic hydrogen transfer agent.

CARBON-CARBON BOND FORMATION BY MEANS OF SUBSTITUTION AND ADDITION REACTIONS INVOLVING THE POLYMER-SUPPORTED CARBANION FROM METHYL NITROACETATE

A polymer-supported carbanion has been prepared from methyl nitroacetate and reacted with alkyl halides or activated olefins to give α-nitroesters.

α-Nitro Ketones and Esters from Acylimidazoles

The anion of 2-(2-nitroethyl)-1,3-dioxolane (4), prepared from the corresponding 2-bromo compound (3), undergoes condensation with acylimidazoles to give the 3-nitro-4-oxobutanal acetals (9), which can serve as valuable polyfunctional intermediates.Condensation with 1-(methoxyoxalyl)imidazole gives the tetrafunctionalized methyl 4-(1,3-dioxolan-2-yl)-3-nitro-2-oxobutanoate (13), which, however, decomposed on attempted deprotection of the ester function.The syntheses in excellent yields of simple α-nitro ketones and α-nitro esters from acylimidazoles and nitroethane and 2-nitropropane are also described.