62965-57-5Relevant articles and documents
The Strecker reaction coupled to Viedma ripening: A simple route to highly hindered enantiomerically pure amino acids
Baglai, Iaroslav,Leeman, Michel,Wurst, Klaus,Kaptein, Bernard,Kellogg, Richard M.,Noorduin, Willem L.
supporting information, p. 10832 - 10834 (2018/10/02)
The Strecker reaction is broadly used for the preparation of α-amino acids. However, control of enantioselectivity remains challenging. We here couple the Strecker reaction to Viedma ripening for the absolute asymmetric synthesis of highly sterically hindered α-amino acids. As proof-of-principle, the enantiomerically pure α-amino acids tert-leucine and α-(1-adamantyl)glycine were obtained.
Henry reaction catalyzed by new series of imidazolidine-4-one Cu-complexes
Drabina, Pavel,Horáková, Eva,R??i?ková, Zdeňka,Sedlák, Milo?
, p. 141 - 147 (2015/02/19)
A series of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-ones have been prepared and their Cu(II) complexes studied as enantioselective catalysts of the asymmetric Henry reaction of various aldehydes with nitromethane. It was found that these compounds w
Dynamic kinetic resolution of α-aminonitriles to form chiral α-amino acids
Yasukawa, Kazuyuki,Hasemi, Ryuji,Asano, Yasuhisa
supporting information; scheme or table, p. 2328 - 2332 (2011/10/19)
We have succeeded in the enzymatic synthesis of (R)-α-aminobutyric acid from racemic α-aminobutyronitrile. This has been demonstrated by the use of non-stereoselective nitrile hydratase (NHase) from Rhodococcus opacus 71D, D-aminopeptidase from Ochrobactrum anthropi C1-38 and α-amino-ε- caprolactam (ACL) racemase from Achromobacter obae. Racemic α- aminobutyronitrile was completely converted in 6 h at 30 °C to (R)-α-aminobutyric acid whose optical purity was more than 99%. (S)-α-Aminobutyric acid was also synthesized from α- aminobutyronitrile by NHase, ACL racemase and L-amino acid amidase from Brevundimonas diminuta TPU 5720. In a similar manner, other (R)- or (S)-α-amino acids with more than 97.5% ee could be synthesized from the corresponding α-aminonitriles. This is the first report on the dynamic kinetic resolution (DKR) of α-aminonitriles to form chiral α-amino acids. The key enzyme in this DKR is non-stereoselective NHase, which had been newly screened from soil samples, and its gene cloned. Copyright
INDAZOLE DERIVATIVES
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, (2011/02/25)
This invention relates to compounds, pharmaceutical compositions and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a mammal in need of such treatment a
BENZIMIDAZOLONE DERIVATIVES
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Page/Page column 29, (2009/12/23)
This invention relates to compounds and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a mammal in need of such treatment a therapeutically effective am
Azapeptide derivatives as HIV protease inhibitors
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Page/Page column 40, (2009/01/24)
This invention relates to novel compounds of the Formula Ib: that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir.
ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS
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Page/Page column 100-101, (2008/06/13)
Antitumoral compounds of general formula (I) obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
BENZIMIDAZOLONE DERIVATIVES AS CB2 RECEPTOR LIGANDS
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Page/Page column 37, (2008/06/13)
This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds and the use of suc
Method for the preparation of enantiomerically enriched compounds
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, (2008/06/13)
Process for the preparation of a diasteromerically enriched phenylglycine amide derivative in which an enantomerically enriched phenylglycine amide is converted into the corresponding Schiff base with the aid of compound R2—C(O)—R3, and the Schiff base obtained is subsequently converted into the diastereomerically enriched phenyglycine amide derivative with the aid of a cyanide source, a reducing agent or an allyl organometallic compound. The phenylglycine amide derivatives obtained are interesting starting materials for the preparation of for example enantimerically enriched α- and or β-amino acids and derivatives thereof, such as amides and esters, and amines.
Process for producing optically active alpha-amino acid and optically active alpha-amino acid amine
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, (2008/06/13)
The present invention provides a process for efficiently producing an optically active α-amino acid and an optically active α-amino acid amide. After contacting with cells or processed cells thereof having an ability to asymmetrically hydrolyse, a water solvent is substituted with at least one solvent selected from the group consisting of linear, branched, or cyclic alcohol having 3 or more carbon atoms and the optically active α-amino acid is preferentially precipitated from the alcohol solution. The addition of basic compounds, particularly potassium compounds to the alcohol solution containing the optically active α-amino acid amide, which is obtained after the separation of the optically active α-amino acid, enables the purification of the amide without the inclusion of amino acid into amino acid amide. Thus, the amide is subjected to the step of racemization and then recycled.
