63124-11-8

Basic information

• Product Name: 2-OXO-1,2-DIHYDROQUINOLINE-6-CARBONITRILE
• Synonyms: 2-OXO-1,2-DIHYDROQUINOLINE-6-CARBONITRILE;6-CYANO-2-QUINOLONE;6-cyanoquinolin-2(1H)-one
• CAS NO: 63124-11-8
• Molecular Formula: C₁₀H₆N₂O
• Molecular Weight: 170.16744
• Mol File: 63124-11-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 420.2 °C at 760 mmHg
• Flash Point: 207.9 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 2.86E-07mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-OXO-1,2-DIHYDROQUINOLINE-6-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-1,2-DIHYDROQUINOLINE-6-CARBONITRILE(63124-11-8)
• EPA Substance Registry System: 2-OXO-1,2-DIHYDROQUINOLINE-6-CARBONITRILE(63124-11-8)

Safety Data

• Hazardous Substances Data: 63124-11-8(Hazardous Substances Data)

Usage

General Description

2-Oxo-1,2-dihydroquinoline-6-carbonitrile is a chemical compound of the quinoline family. Structurally, it contains a core quinoline ditrine with a carbonyl group at the 2 position, a carbonitrile group at the 6 position, and is in a dihydro form, meaning some of its double bonds are reduced to single ones. This chemical bears significant potential for scientific and industrial usage owing to its embedded groups which may partake in various chemical reactions. While there is limited information available on its specific applications, it is likely used as a precursor or intermediate for synthesis in chemical and pharmaceutical industries due to its structural relevance. However, like many chemicals, it should be handled with caution as it may pose risks if improperly managed.

InChI:InChI=1/C10H6N2O/c11-6-7-1-3-9-8(5-7)2-4-10(13)12-9/h1-5H,(H,12,13)

Upstream product

• 23395-72-4 quinoline-6-carbonitrile 
• 1810-66-8 6-bromo-2-quinolone 
• 327058-51-5 N-(4-bromophenyl)-(E)-3-ethoxyacrylamide 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 78060-54-5 2-chloroquinoline-6-carbonitrile 

Relevant articles and documents

2 - (1 H) - quinoline compound of microwave-assisted synthesis method (by machine translation)

The invention belongs to the field of organic intermediate synthesis, in particular discloses a 2 - (1 H) - quinoline compound of microwave-assisted synthetic method: quinoline raw material, and water in a reaction promoter and microwave under the assistance of the addition reaction, to obtain the 2 - (1 H) - quinoline compound; the quinoline raw material is quinoline, or on the quinoline ring in addition to the 2 other than the position of the substituent on the quinoline derivatives containing; the reaction accelerator is 2 - chloroethyl ester and/or 2 - [...] ester. The method raw materials are easy, simple reaction conditions, the reaction time is short, green energy-saving, reaction selectivity and high yield, excellent substrate functional group compatibility, and has high application value. (by machine translation)

2-(4-Alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists

With the aim of identifying structurally novel, centrally acting histamine H3 antagonists, a series of 2-(4-alkylpiperazin-1-yl)quinolines was prepared. Systematic variation of the substituents led to highly potent histamine H3 antagonists with low polar surface area and appropriate log P for blood-brain barrier penetration.