6336-52-3Relevant articles and documents
One-pot method for α-phenylation of ketones using isoxazolidine and triphenylaluminum
Miyoshi, Tetsuya,Sato, Shohei,Tanaka, Hiroya,Hasegawa, Chihiro,Ueda, Masafumi,Miyata, Okiko
experimental part, p. 4188 - 4191 (2012/08/28)
The efficient one-pot umpolung α-phenylation of ketones via N-alkenylisoxazolidine is described. When the various ketones are treated with triphenylaluminum prepared from phenylmagnesium chloride and AlCl3 in the presence of isoxazolidine, the desired products are obtained in good to moderate yield. This method is equivalent to a direct α-arylation reaction of carbonyl groups.
Regioselective Arylation Reactions of Biphenyl-2-ols, Naphthols, and Benzylic Compounds with Aryl Halides under Palladium Catalysis
Satoh, Tetsuya,Inoh, Jun-Ichi,Kawamura, Yoshiki,Kawamura, Yuichiro,Miura, Masahiro,Nomura, Masakatsu
, p. 2239 - 2246 (2007/10/03)
Biphenyl-2-ols undergo regioselective mono- and diarylation upon a treatment with aryl iodides in the presence of a palladium catalyst in DMF using Cs2CO3 as a base to produce 1,1′ : 2′,1″-terphenyl-2-ol and 2′,6′-diphenylbiphenyl-2-ol and their derivatives. The reaction of 1-naphthol selectively occurs at its 8-position to give 8-aryl-1-naphthols. In the reaction of 2-naphthol with aryl bromides, diarylated compounds, 1-(2-arylphenyl)-2-naphthols, are formed as the single major products. Under similar conditions, benzyl ketones, phenylacetonitrile, and methyl phenylacetate are arylated at their benzylic position.
Synthesis of 2,2-Diphenyl-3-oxetanol Derivatives and Their Thermal or Acid-catalyzed Decomposition
Shimizu, Nobujiro,Yamaoka, Shintaro,Tsuno, Yuho
, p. 3853 - 3854 (2007/10/02)
A series of five different 2,2-diphenyl-3-oxetanols was synthesized by photocycloadditiion of benzophenone and enol trimethylsilyl ethers followed by protolysis of the resultant 3-trimethylsiloxyoxetanes.Thermal cleavage and acid-catalyzed rearrangement of these oxetanes are described.
