65515-33-5

Basic information

• Product Name: 6-chloro-2-methoxynicotinic acid
• Synonyms: 6-chloro-2-methoxynicotinic acid;6-Chloro-2-methoxypyridine-3-carboxylic acid
• CAS NO: 65515-33-5
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58044
• Mol File: 65515-33-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 322.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.430±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.13±0.10(Predicted)
• CAS DataBase Reference: 6-chloro-2-methoxynicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-methoxynicotinic acid(65515-33-5)
• EPA Substance Registry System: 6-chloro-2-methoxynicotinic acid(65515-33-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 65515-33-5(Hazardous Substances Data)

Usage

General Description

6-chloro-2-methoxynicotinic acid is a chemical compound with the molecular formula C8H7ClNO3. It is a derivative of nicotinic acid, also known as niacin, and is characterized by the presence of a chlorine atom and a methoxy group on the nicotinic acid molecule. 6-chloro-2-methoxynicotinic acid has shown potential as a building block for the synthesis of pharmaceuticals and agrochemicals, due to its unique structure and reactivity. It is also being studied for its potential biological activities, including its role as an anti-inflammatory and anti-cancer agent. Additionally, 6-chloro-2-methoxynicotinic acid is used as a key intermediate in the development of new compounds with diverse applications in the fields of medicine and agriculture.

Upstream product

• 67-56-1 methanol 
• 55366-30-8 2,6-dichloro-3-(trichloromethyl)pyridine 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 124-41-4 sodium methylate 

Downstream Products

• 65515-32-4 methyl 6-chloro-2-methoxypyridine-3-carboxylate 
• 1393844-12-6 2,2-dimethyl-7-((2-(trifluoromethyl)phenyl)ethynyl)-2H-pyrano[2,3-b]pyridin-4(3H)-one 
• 1393844-16-0 7-((2-chloro-5-(trifluoromethyl)phenyl)ethynyl)-2,2-dimethyl-2H-pyrano[2,3-b]pyridin-4(3H)-one 
• 1393844-14-8 7-((2-fluoro-6-(trifluoromethyl)phenyl)ethynyl)-2,2-dimethyl-2H-pyrano[2,3-b]pyridin-4(3H)-one 
• 1393844-08-0 2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione 
• 1393844-15-9 7-{[2-chloro-5-(trifluoromethyl)phenyl]ethynyl}-2,2-dimethyl-2H-pyrano[2,3-b]pyridin-3,4-dione 
• 1393844-13-7 7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-2,2-dimethyl-2H-pyrano[2,3-b]pyridine-3,4-dione 
• 102978-40-5 4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione 

Relevant articles and documents

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.

CONTRASTING REACTIONS OF 2,6-DICHLORO-4-TRICHLOROMETHYLPYRIDINE, 2,6-DICHLORO-3-TRICHLOROMETHYLPYRIDINE AND THEIR N-OXIDES WITH NUCLEOPHILES

Various nucleophiles react with 2,6-dichloro-4-trichloromethylpyridine and 2-chloro-6-trichloromethylpyridine as expected, by displacement of ring chlorine atoms.But in the reactions of nucleophiles with 2,6-dichloro-3-trichloromethylpyridine and 2,6-difluoro-3-trifluoromethylpyridine, displacement of ring halogen atoms is accompained or followed by multiple attack at the trihalogenomethyl group.The reactivity of the trihalogenomethyl groups is modified by N-oxidation.A mechanism for the peculiar reactivity of the trihalogenomethyl groups is proposed, involving loss of halide ion from the CX3 group assisted by Ione pairs on substituents or negative charge in Meisenheimer intermediates.Both geometrical isomers of 1,2-dichloro-1,2-bis(2,6-dichloro-3-pyridyl)ethene are described.