65515-33-5

Basic information

• Product Name: 6-chloro-2-methoxynicotinic acid
• Synonyms: 6-chloro-2-methoxynicotinic acid;6-Chloro-2-methoxypyridine-3-carboxylic acid
• CAS NO: 65515-33-5
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58044
• Mol File: 65515-33-5.mol

Chemical Properties

• Boiling Point: 322.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.430±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.13±0.10(Predicted)
• CAS DataBase Reference: 6-chloro-2-methoxynicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-methoxynicotinic acid(65515-33-5)
• EPA Substance Registry System: 6-chloro-2-methoxynicotinic acid(65515-33-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 65515-33-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-chloro-2-methoxynicotinic acid is used as a key intermediate for the synthesis of new pharmaceutical compounds, leveraging its unique structure and reactivity to develop drugs with diverse therapeutic applications.
Used in Agrochemical Industry:
6-chloro-2-methoxynicotinic acid is utilized as a building block in the development of new agrochemicals, contributing to the creation of innovative products for agricultural use.
Used in Anti-inflammatory Applications:
6-chloro-2-methoxynicotinic acid is being studied for its potential as an anti-inflammatory agent, with the aim of developing new treatments for inflammatory conditions.
Used in Anti-cancer Applications:
6-chloro-2-methoxynicotinic acid is being investigated for its potential role as an anti-cancer agent, with research focusing on its ability to target and inhibit cancer cell growth and proliferation.

Upstream product

• 67-56-1 methanol 
• 55366-30-8 2,6-dichloro-3-(trichloromethyl)pyridine 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 124-41-4 sodium methylate 

Downstream Products

• 65515-32-4 methyl 6-chloro-2-methoxypyridine-3-carboxylate 
• 1393844-12-6 2,2-dimethyl-7-((2-(trifluoromethyl)phenyl)ethynyl)-2H-pyrano[2,3-b]pyridin-4(3H)-one 
• 1393844-16-0 7-((2-chloro-5-(trifluoromethyl)phenyl)ethynyl)-2,2-dimethyl-2H-pyrano[2,3-b]pyridin-4(3H)-one 
• 1393844-14-8 7-((2-fluoro-6-(trifluoromethyl)phenyl)ethynyl)-2,2-dimethyl-2H-pyrano[2,3-b]pyridin-4(3H)-one 
• 1393844-08-0 2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione 
• 1393844-15-9 7-{[2-chloro-5-(trifluoromethyl)phenyl]ethynyl}-2,2-dimethyl-2H-pyrano[2,3-b]pyridin-3,4-dione 
• 1393844-13-7 7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-2,2-dimethyl-2H-pyrano[2,3-b]pyridine-3,4-dione 
• 102978-40-5 4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione 

Relevant articles and documents

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.

First synthesis of methyl 2-amino-6-methoxynicotinate using a combination of microwave and flow reaction technologies

The synthesis of methyl 2-amino-6-methoxynicotinate, a valuable building block for the preparation of fused 2-pyridones, is reported. The optimized synthesis includes sequential microwave-induced regioselective 6-methoxylation, esterification, followed by microwave-induced reaction with p- methoxybenzylamine, and final deprotection under flow reaction hydrogenation conditions. Two key steps in the reported synthesis are a microwave-induced methoxylation and a microfluidic hydrogenation that afford improved regioselectivity and purity profile of the reaction products. Georg Thieme Verlag Stuttgart.

CONTRASTING REACTIONS OF 2,6-DICHLORO-4-TRICHLOROMETHYLPYRIDINE, 2,6-DICHLORO-3-TRICHLOROMETHYLPYRIDINE AND THEIR N-OXIDES WITH NUCLEOPHILES

Various nucleophiles react with 2,6-dichloro-4-trichloromethylpyridine and 2-chloro-6-trichloromethylpyridine as expected, by displacement of ring chlorine atoms.But in the reactions of nucleophiles with 2,6-dichloro-3-trichloromethylpyridine and 2,6-difluoro-3-trifluoromethylpyridine, displacement of ring halogen atoms is accompained or followed by multiple attack at the trihalogenomethyl group.The reactivity of the trihalogenomethyl groups is modified by N-oxidation.A mechanism for the peculiar reactivity of the trihalogenomethyl groups is proposed, involving loss of halide ion from the CX3 group assisted by Ione pairs on substituents or negative charge in Meisenheimer intermediates.Both geometrical isomers of 1,2-dichloro-1,2-bis(2,6-dichloro-3-pyridyl)ethene are described.