67973-33-5Relevant articles and documents
CHEMICAL COMPOUNDS FOR COATING OF NANOSTRUCTURES
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Page/Page column 47; 48; 53; 54, (2018/08/03)
The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core, wherein the aromatic core is a benzene ring or a biphenyl; the carbocyclic, non-aromatic core is a 5 to 7 membered ring. The core has
Arginine-linked neomycin B dimers: Synthesis, rRNA binding, and resistance enzyme activity
Jin, Yi,Watkins, Derrick,Degtyareva, Natalya N.,Green, Keith D.,Spano, Meredith N.,Garneau-Tsodikova, Sylvie,Arya, Dev P.
supporting information, p. 164 - 169 (2016/01/30)
The nucleotides comprising the ribosomal decoding center are highly conserved, as they are important for maintaining translational fidelity. The bacterial A-site has a small base variation as compared with the human analogue, allowing aminoglycoside (AG) antibiotics to selectively bind within this region of the ribosome and negatively affect microbial protein synthesis. Here, by using a fluorescence displacement screening assay, we demonstrate that neomycin B (NEO) dimers connected by l-arginine-containing linkers of varying length and composition bind with higher affinity to model A-site RNAs compared to NEO, with IC50 values ranging from ~40-70 nM, and that a certain range of linker lengths demonstrates a clear preference for the bacterial A-site RNA over the human analogue. Furthermore, AG-modifying enzymes (AMEs), such as AG O-phosphotransferases, which are responsible for conferring antibiotic resistance in many types of infectious bacteria, demonstrate markedly reduced activity against several of the l-arginine-linked NEO dimers in vitro. The antimicrobial activity of these dimers against several bacterial strains is weaker than that of the parent NEO.
Synthesis of a novel dinuclear ruthenium polypyridine dye for dye-sensitized solar cells application
Zalas,Gierczyk,Klein,Siuzdak,P?dziński,?uczak
supporting information, p. 381 - 387 (2013/11/06)
A new dinuclear ruthenium(II) polypyridine complex has been successfully synthesized. The new compound has been characterized by spectroscopic and electrochemical methods. Its potential application as a sensitizing dye in dye-sensitized solar cells has been checked under AM 1.5 G irradiation conditions (100 mW cm-2) and its performance was compared to that of a commercially available mononuclear analogous dye. The overall light-to-electricity conversion efficiency of the photovoltaic device sensitized by the new dinuclear dye has been found to be over 2.5 times lower than that sensitized by the commercial analogue, despite a much higher extinction coefficient of the former dye. The probable reasons for the lower photovoltaic activity are discussed.
Facile preparation of aromatic esters from aromatic bromides with ethyl formate or DMF and molecular iodine via aryllithium
Ushijima, Sousuke,Moriyama, Katsuhiko,Togo, Hideo
experimental part, p. 4701 - 4709 (2012/07/28)
Various aromatic bromides were treated with n-BuLi and subsequently with ethyl formate, followed by the reaction with ethanol and molecular iodine in the presence of K2CO3 to provide the corresponding aromatic ethyl esters in good yields. Moreover, aromatic bromides could be transformed into the corresponding aromatic methyl esters in good yields by the treatment with n-BuLi and subsequently with DMF, followed by the reaction with methanol, molecular iodine, and K2CO3. Some aromatics could be also converted into the corresponding aromatic esters in good yields by the treatment with n-BuLi, and subsequently with ethyl formate or DMF, followed by the reaction with molecular iodine and K2CO3. The present reactions offer a novel route for the transition-metal-free, carbon-monoxide-free, and therefore environmentally benign one-pot conversion of aromatic bromides and aromatics into aromatic esters.
Synthesis of new dendritic antenna-like polypyridine ligands
Zalas, Maciej,Gierczyk, Blazej,Ceglowski, Michal,Schroeder, Grzegorz
, p. 733 - 740 (2013/07/26)
An efficient synthesis of multidentate polypyridine ligands, 3,5-bis(2,2′-bipyridin-4-ylethynyl)benzoic acid and 3,5-bis(2,5-bis(2- pyridyl)-pyridin-4-ylethynyl)benzoic acid, with potential application in the production of ruthenium dyes for dye-sensitised solar cells was developed. Isolation of intermediate products and final compounds is simple and the yields are very high. The ligands obtained can be used in the synthesis of dendritic analogues of well known and very efficient N3 dye and "black dye".
Self-assembled helical conjugated poly(m-phenylene) derivatives that afford whiskers with hexagonal columnar packed structure
Suda, Kiyoshi,Akagi, Kazuo
experimental part, p. 9473 - 9488 (2012/03/27)
We have synthesized a series of π-conjugated polymers, poly(m-phenylene) [PMP] derivatives with chiral or racemic alkyl groups in side chains. Peculiar liquid crystalline phases or crystalline structures based on helical conjugated polymer main chains are
Design, synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors
Zhao, Wen Jing,Shi, Yong Heng,Zhao, Gui Long,Wang, Yu Li,Shao, Hua,Da Tang, Li,Wang, Jian Wu
scheme or table, p. 1215 - 1218 (2012/02/02)
A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors, with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key step. The in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test (OGTT), and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin.
An easy and multigram-scale synthesis of versatile AA- and AB-type w-terphenylenes as building blocks for kinked polyphenylenes
Kissel, Patrick,Breitier, Simon,Reinmueller, Viktoria,Lanz, Patrick,Federer, Lukas,Schlueter, A. Dieter,Sakamoto, Junji
supporting information; experimental part, p. 2953 - 2955 (2009/11/30)
A set of m-terphenylenes having a readily functionalizable hydroxy group as well as either symmetric AA-type or unsymmetric AB-type halide termini have been prepared on a several-gram scale. The synthesis was carried out on the basis of the Suzuki-Miyaura
Palladium-catalyzed oxidative carbonylation of alkyl and aryl indium reagents with CO under mild conditions
Zhao, Yingsheng,Jin, Liqun,Li, Peng,Lei, Aiwen
supporting information; body text, p. 9429 - 9433 (2009/02/03)
CO now can react with organoindium reagents. A novel palladium-catalyzed oxidative carbonylation reaction of organoindium reagents by CO gas with desyl chloride as oxidant was developed in supplementation with the classical methods for preparation of carboxylic acid derivatives. Primary, secondary alkyl indium reagents with β-hydrogens and aryl indium reagents were suitable substrates, and the reaction could be carried out at 60°C under 50 psi CO. Carbonylation of alkyl indium reagents can occur smoothly without additional base. Although the indium reagents were prepared from corresponding Grignard reagents (at low temperature), they displayed full compatibility with various functional groups under the protic reaction conditions. Preliminary mechanistic studies including stoichiometric and catalytic reaction examination provided evidence to support the operation of the mechanism consisted of oxidative addition of deslyl chloride to Pd(0) and quick tautomerization to give a palladium enolate species II (ROPdCl), displacement of the enolate group in II by R2OH, followed by CO insertion to give alkoxycarbonyl palladium complex V, which undergoes transmetalation with R13ln and reductive elimination to afford the product and a Pd(0) species. In this mechanism, the alkoxycarbonyl group was transferred to the palladium center prior to the alkyl group, different from traditional ways initiated from oxidative addition of alkyl halides to a Pd(0) species.
Synthesis and evaluation of a solid supported molecular tweezer type receptor for cholesterol
Davidson, Louise,Blencowe, Anton,Drew, Michael G. B.,Freebairn, Keith W.,Hayes, Wayne
, p. 758 - 766 (2007/10/03)
A new macroporous stationary phase bearing 'tweezer' receptors that exhibit specificity for cholesterol has been constructed from rigid multifunctional vinylic monomers derived from 3,5-dibromobenzoic acid, propargyl alcohol and cholesterol. The synthesis
