67985-73-3Relevant articles and documents
Total synthesis of Punicagranine
Perry, Charles K.,Lindsley, Craig W.
, (2019)
This communication details the first total synthesis of Punicagranine, a new pyrrolizine alkaloid isolated from the peels of the pomengranate, Punica granatum, the basis for traditional Chinese medicine, with anti-inflammatory activity. Two concise, 4–5 step routes were developed to rapidly prepare Punicagranine in 10.7–12.1% overall yields. One route features an intramolecular Heck reaction, while the other relies on a 1,3-dipolar cycloaddition. The latter route proceeds on scale to support future biological studies.
2,3-DIHYDRO-1H-PYRROLIZINE-7-FORMAMIDE DERIVATIVE AND APPLICATION THEREOF
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Paragraph 0134-0137, (2021/04/16)
The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.
HEPATITIS B CAPSID ASSEMBLY MODULATORS
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Paragraph 0390; 0391, (2019/12/30)
Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.
Zinc phthalocyanine as an efficient catalyst for halogen-free synthesis of formamides from amines via carbon dioxide hydrosilylation under mild conditions
Luo, Rongchang,Lin, Xiaowei,Lu, Jing,Zhou, Xiantai,Ji, Hongbing
, p. 1382 - 1389 (2017/08/22)
The combination of a zinc phthalocyanine (ZnPc) catalyst and a stoichiometric amount of dimethyl formamide (DMF) provided a simple route to formamide derivatives from amines, CO2, and hydrosilanes under mild conditions. We deduced that formation of an active zinc-hydrogen (Zn-H) species promoted hydride transfer from the hydrosilane to CO2. The cooperative activation of the Lewis acidic ZnPc by strongly polar DMF, led to formation of activated amines and hydrosilanes, which promoted the chemical reduction of CO2. Consequently, the binary ZnPc/DMF catalytic system showed excellent yields and superior chemoselectivity, representing a simple and sustainable pathway for the reductive transformation of CO2 into valuable chemicals as an alternative to conventional halogen-containing process.
Synthesis of new types of aminomethylenediphosphorus-containing acids and their derivatives
Prishchenko,Livantsov,Novikova,Livantsova,Ershov,Petrosyan
, p. 370 - 379 (2015/04/14)
Convenient methods for synthesis of various aminomethylenediphosphorus-containing acids and their derivatives starting from available trimethylsilyl esters of hypophosphorous and phosphorous acids, ethoxymethyleneimine hydrochlorides, and N-substituted formamides have been proposed. Selected properties of the obtained compounds have been examined.
SYNTHESIS AND REACTIVITY OF THE BENZIMIDAZOLIDES OF N-FORMYLATED AND N-PROTONATED AMINO ACIDS
Purygin, P. P.,Pron', A. N.
, p. 908 - 910 (2007/10/02)
The reactivity of the benzimidazolides of N-formylated and N-protonated amino acids was studied, and it was shown that they can be used in the synthesis of O-aminoacyl derivatives of nucleotides.
