7150-72-3

Basic information

• Product Name: tert-butyl N-ethenylcarbamate
• Synonyms: tert-butyl N-ethenylcarbamate;tert-butyl vinylcarbamate
• CAS NO: 7150-72-3
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.19
• Mol File: 7150-72-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 65-67 °C(Solv: ethyl acetate (141-78-6); pentane (109-66-0))
• Boiling Point: 169.4°C at 760 mmHg
• Flash Point: 56.3°C
• Appearance: /
• Density: 0.944g/cm³
• Vapor Pressure: 1.54mmHg at 25°C
• Refractive Index: 1.435
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 11.25±0.46(Predicted)
• CAS DataBase Reference: tert-butyl N-ethenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-ethenylcarbamate(7150-72-3)
• EPA Substance Registry System: tert-butyl N-ethenylcarbamate(7150-72-3)

Safety Data

• Hazardous Substances Data: 7150-72-3(Hazardous Substances Data)

Usage

General Description

Tert-butyl N-ethenylcarbamate is a chemical compound that is primarily used in pharmaceutical and agricultural applications. It is a carbamate ester, which is a class of organic compounds that are derived from carbamic acid. Tert-butyl N-ethenylcarbamate is used as a chemical intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. It is known for its ability to efficiently protect sensitive functional groups in chemical reactions, making it a valuable tool in organic synthesis. Additionally, it has shown potential as a potential antifungal and herbicidal agent in agricultural applications. Overall, tert-butyl N-ethenylcarbamate is a versatile chemical compound with a wide range of applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C7H13NO2/c1-5-8-6(9)10-7(2,3)4/h5H,1H2,2-4H3,(H,8,9)

Upstream product

• 13162-05-5 n-vinylformamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 24608-52-4 tert-butyl chloroformate 
• 814-68-6 acryloyl chloride 
• 75-65-0 tert-butyl alcohol 
• 1321892-09-4 N-formyl-N-vinyl-carbamic acid tert-butyl ester 
• 50830-56-3 acryloyl azide 
• 3555-94-0 isocyanatoethene 

Downstream Products

• 1630984-87-0 tert-butyl (5S,7S)-7-((tert-butoxycarbonyl)amino)-3-methyl-5-(4-nitrophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine-1-carboxylate 
• 1630984-98-3 tert-butyl (5S,7S)-7-((tert-butoxycarbonyl)amino)-5-(3-chlorophenyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine-1-carboxylate 
• 1630984-88-1 tert-butyl (5S,7S)-7-((tert-butoxycarbonyl)amino)-5-(3-nitrophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine-1-carboxylate 
• 1630985-05-5 tert-butyl (5S,7S)-7-((tert-butoxycarbonyl)amino)-5-(3-methoxyphenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine-1-carboxylate 
• 1630985-06-6 tert-butyl (5S,7S)-7-((tert-butoxycarbonyl)amino)-5-(m-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine-1-carboxylate 
• 177736-04-8 methyl 4-[2-(tert-butoxycarbonylamino)ethyl]benzoate 
• 38427-90-6 N-(t-butoxycarbonyl)phenethylamine 

Relevant articles and documents

Nickel-catalyzed carbodifunctionalization of: N -vinylamides enables access to γ-amino acids

A nickel-catalyzed tandem reaction of N-vinylamides with arylboronic acids and bromodifluoroacetate has been developed. The use of amide carbonyl as a chelating group efficiently furnishes a series of protected α,α-difluoro-γ-amino acid esters. The reaction can also extend to bromoacetate and 2-bromomalonate. The advantages of this protocol are high functional group tolerance and a broad substrate scope, including a variety of N-vinylamides. In particular, the use of removable amide carbonyl groups provides potential opportunities for applications in peptide chemistry and protein engineering.

Anti-Markovnikov hydroarylation of alkenes via polysulfide anion photocatalysis

A protocol for anti-Markovnikov hydroarylation of alkenes with aryl halides has been developed using polysulfide anions as photocatalysts in the presence of the Hantzsch ester and water under irradiation with visible light.

Catalytic Strategy for Regioselective Arylethylamine Synthesis

A mild, modular, and practical catalytic system for the synthesis of the highly privileged phenethylamine pharmacophore is reported. Using a unique combination of organic catalysts to promote the transfer of electrons and hydrogen atoms, this system performs direct hydroarylation of vinyl amine derivatives with a wide range of aryl halides (including aryl chlorides). This general and highly chemoselective protocol delivers a broad range of arylethylamine products with complete regiocontrol. The utility of this process is highlighted by its scalability and the modular synthesis of an array of bioactive small molecules.