7541-49-3

Basic information

• Product Name: 3,7,11,15-TETRAMETHYL-2-HEXADECEN-1-OL
• Synonyms: 3,7,11,15-TETRAMETHYL-2-HEXADECEN-1-OL;PHYTOL;PHYTOL 97+%;PHYTOL, 97%, MIXTURE OF ISOMERS;Phytolnaturalisomer;2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-;Phytol ,90% [mixture of isomers];Phytol 99+% (Natural isoMer.)
• CAS NO: 7541-49-3
• Molecular Formula: C₂₀H₄₀O
• Molecular Weight: 296.53
• EINECS: 205-776-6
• Product Categories: Acyclic;Alkenes;Building Blocks;Chemical Synthesis;Metabolic Pathways;Metabolomics;Organic Building Blocks;Terpenoid Metabolism;Terpenoids
• Mol File: 7541-49-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 202-204 °C10 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /Liquid
• Density: 0.85 g/mL at 25 °C(lit.)
• Vapor Pressure: 8.32E-06mmHg at 25°C
• Refractive Index: n20/D 1.463(lit.)
• Storage Temp.: 2-8°C
• PKA: 14.73±0.10(Predicted)
• BRN: 1726098
• CAS DataBase Reference: 3,7,11,15-TETRAMETHYL-2-HEXADECEN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7,11,15-TETRAMETHYL-2-HEXADECEN-1-OL(7541-49-3)
• EPA Substance Registry System: 3,7,11,15-TETRAMETHYL-2-HEXADECEN-1-OL(7541-49-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• Hazardous Substances Data: 7541-49-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless to yellow liquid

Uses

Phytol is a reagent that is used in the preparation of α-tocopherol analogs as mitochondrial antioxidants.

General Description

Phytol is a diterpene alcohol and is widely used as a food additive and in medicinal field. It undergoes Mitsunobu reaction with 5-fluorouridine to yield the nucleoterpenes.

Biochem/physiol Actions

Phytol exhibits potential anti-Schistosomal properties. It induces sedative and anxiolytic-like effects in mice.

InChI:InChI=1/C20H40O/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h15,17-19,21H,6-14,16H2,1-5H3

Synthetic route

isophytol (505-32-8) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Stage #1: isophytol With phosphorus tribromide In n-heptane at -10 - 0℃; for 1h; Stage #2: With sodium hydroxide In water at 50 - 60℃; for 2h; pH=6 - 7;	89%
Multi-step reaction with 3 steps 1: hydrogenchloride; tetramethlyammonium chloride / water / 10 - 20 °C / Large scale 2: tetramethlyammonium chloride / acetonitrile / 50 - 60 °C / Large scale 3: sodium hydroxide; water / 40 - 50 °C / Large scale View Scheme

6,10,14-Trimethyl-2-pentadecanon (502-69-2) + C7H13ClMgO2 → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Stage #1: 6,10,14-Trimethyl-2-pentadecanon; C7H13ClMgO2 In tert-butyl methyl ether at 0℃; for 6h; Inert atmosphere; Stage #2: With pyridinium p-toluenesulfonate In ethanol; water for 2h; Reflux;	84%

[3-methyl-3-(4,8,12-trimethyl-tridecyl)-oxiranyl]-methanol (107438-44-8) → neophytadiene (504-96-1, 508181-25-7) + isophytol (505-32-8) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
With methyltrioxorhenium(VII); triphenylphosphine In toluene for 3h; Reflux;	A 7.4% B n/a C n/a

isophytol (505-32-8) → neophytadiene (21980-71-2) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
With acetic anhydride at 96 - 97℃; dann Verseifen mit methylalkoholischer Kalilauge;

isophytol (505-32-8) + acetic anhydride (108-24-7) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
at 96 - 97℃; nachfolgende Verseifung mit methylalkoholischer Kalilauge;

3,7,11,15-tetramethyl-hexadec-2-enoic acid ethyl ester (5492-31-9) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether

ethyl-5,9-dimethyldec-2-anoate (10236-11-0) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 6 steps 1: (i) NaH, THF, (ii) Al-Hg, aq. THF 2: (i) NaH, DMF, (ii) /BRN= 1722657/ 3: H2 / Pd-CaCO3 / ethanol / 76000 Torr / Ambient temperature 4: (i) NaH, THF, (ii) Al-Hg, aq. THF 5: (i) NaH, THF, (ii) /BRN= 1724987/ 6: LiAlH4 / diethyl ether View Scheme

6-methylheptan-2-one (928-68-7) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 8 steps 1: (i) NaH, THF, (ii) /BRN= 635835/ 2: H2 / Pd-CaCO3 / ethanol / 76000 Torr / Ambient temperature 3: (i) NaH, THF, (ii) Al-Hg, aq. THF 4: (i) NaH, DMF, (ii) /BRN= 1722657/ 5: H2 / Pd-CaCO3 / ethanol / 76000 Torr / Ambient temperature 6: (i) NaH, THF, (ii) Al-Hg, aq. THF 7: (i) NaH, THF, (ii) /BRN= 1724987/ 8: LiAlH4 / diethyl ether View Scheme

2,6-Dimethyl-6,8-nonadien-9-carbonsaeureethylester → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 7 steps 1: H2 / Pd-CaCO3 / ethanol / 76000 Torr / Ambient temperature 2: (i) NaH, THF, (ii) Al-Hg, aq. THF 3: (i) NaH, DMF, (ii) /BRN= 1722657/ 4: H2 / Pd-CaCO3 / ethanol / 76000 Torr / Ambient temperature 5: (i) NaH, THF, (ii) Al-Hg, aq. THF 6: (i) NaH, THF, (ii) /BRN= 1724987/ 7: LiAlH4 / diethyl ether View Scheme

2,6,10-Trimethyl-trideca-10,12-dien-13-carbonsaeureethylester → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 4 steps 1: H2 / Pd-CaCO3 / ethanol / 76000 Torr / Ambient temperature 2: (i) NaH, THF, (ii) Al-Hg, aq. THF 3: (i) NaH, THF, (ii) /BRN= 1724987/ 4: LiAlH4 / diethyl ether View Scheme

(E)-3,7,11,15-tetramethylhexadec-2-en-1-ol (253686-88-3) → neophytadiene (504-96-1, 508181-25-7) + isophytol (505-32-8) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: vanadium trisacetylacetonate; tert.-butylhydroperoxide / hexane; decane / Inert atmosphere; Reflux 2: triphenylphosphine; methyltrioxorhenium(VII) / toluene / 3 h / Reflux View Scheme

Geranylgeraniol (24034-73-9) → neophytadiene (504-96-1, 508181-25-7) + isophytol (505-32-8) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: vanadium trisacetylacetonate; tert.-butylhydroperoxide / toluene / Reflux; Inert atmosphere 2: 5%-palladium/activated carbon; hydrogen / ethanol / 4 h / 40 °C 3: triphenylphosphine; methyltrioxorhenium(VII) / toluene / 3 h / Reflux View Scheme

geranylgeraniol-2,3-epoxide (500996-28-1) → neophytadiene (504-96-1, 508181-25-7) + isophytol (505-32-8) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: 5%-palladium/activated carbon; hydrogen / ethanol / 4 h / 40 °C 2: triphenylphosphine; methyltrioxorhenium(VII) / toluene / 3 h / Reflux View Scheme

6,10,14-trimethyl-5,9,13-pentadecatriene-2-on (1117-52-8) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogen; palladium 10% on activated carbon / ethanol / 24 h / 20 °C / 1520.1 Torr 2.1: tert-butyl methyl ether / 6 h / 0 °C / Inert atmosphere 2.2: 2 h / Reflux View Scheme
Multi-step reaction with 3 steps 1.1: hydrogen; palladium 10% on activated carbon / ethanol / 24 h / 20 °C / 1520.1 Torr 2.1: tert-butyl methyl ether / 2 h / 0 - 5 °C 3.1: phosphorus tribromide / n-heptane / 1 h / -10 - 0 °C 3.2: 2 h / 50 - 60 °C / pH 6 - 7 View Scheme

2-(2-chloroethoxy)-tetrahydro-2H-pyrane (5631-96-9) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: magnesium / tert-butyl methyl ether / 5 h / 50 - 60 °C / Inert atmosphere 2.1: tert-butyl methyl ether / 6 h / 0 °C / Inert atmosphere 2.2: 2 h / Reflux View Scheme

trans geranyl acetone (3796-70-1) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: tert-butyl methyl ether / 6 h / 0 °C / Inert atmosphere 2.1: hydrogen; palladium 10% on activated carbon / ethanol / 24 h / 20 °C / 1520.1 Torr 3.1: tert-butyl methyl ether / 6 h / 0 °C / Inert atmosphere 3.2: 2 h / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: tert-butyl methyl ether / 6 h / 0 °C / Inert atmosphere 2.1: hydrogen; palladium 10% on activated carbon / ethanol / 24 h / 20 °C / 1520.1 Torr 3.1: tert-butyl methyl ether / 2 h / 0 - 5 °C 4.1: phosphorus tribromide / n-heptane / 1 h / -10 - 0 °C 4.2: 2 h / 50 - 60 °C / pH 6 - 7 View Scheme

3,7,11,15-tetramethylhexadec-2-en-1-yl acetate (76337-16-1) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
With methanol; potassium carbonate Reflux; Large scale;
With methanol; sodium carbonate for 12h; Reagent/catalyst; Reflux;	108 g

1-chloro-3,7,11,15-tetramethylhexadec-2-ene (65592-98-5) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: tetramethlyammonium chloride / acetonitrile / 50 - 60 °C / Large scale 2: sodium hydroxide; water / 40 - 50 °C / Large scale View Scheme

(E/Z)-(all-rac)-phytyl formiate → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
With water; sodium hydroxide at 40 - 50℃; Large scale;

1-bromo-3,7,11,15-tetramethylhexadec-2-ene (76524-59-9) → 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide / N,N-dimethyl-formamide / 50 - 60 °C / Large scale 2: potassium carbonate; methanol / Reflux; Large scale View Scheme

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → 3,7,11,15-tetramethyl-hexadecanol (645-72-7)

Conditions	Yield
With hydrogen; sodium hydrogencarbonate; platinum(IV) oxide In tetrahydrofuran under 760.051 Torr; for 20h;	100%
With hydrogen; platinum(IV) oxide In tetrahydrofuran under 760.051 Torr; for 20h;	100%
With hydrogen In ethanol at 20℃; for 104h; Reagent/catalyst; Pressure; Time;	100%

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → [3-methyl-3-(4,8,12-trimethyl-tridecyl)-oxiranyl]-methanol (107438-44-8)

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane	99%
With PW12O40(3-)*polymer; dihydrogen peroxide at 20℃; for 7h;	96%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃;

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → 1-bromo-3,7,11,15-tetramethylhexadec-2-ene (76524-59-9)

Conditions	Yield
With carbon tetrabromide; triphenylphosphine In dichloromethane	91%
With phosphorus tribromide In diethyl ether at 0 - 20℃;	86%
With phosphorus tribromide In hexane at 0℃; for 0.166667h; Inert atmosphere;

formic acid (64-18-6) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → (E/Z)-(all-rac)-phytyl formiate

Conditions	Yield
at 60℃; for 2.5h;	90%

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) + methyl (132R)-propyl-pyropheophorbide a → 132-propyl-pyropheophytin a

Conditions	Yield
With 1,3-dichlorotetrabutyldistannoxane In toluene for 3h; Reflux; Inert atmosphere;	89%

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) + acetic anhydride (108-24-7) → 3,7,11,15-tetramethylhexadec-2-en-1-yl acetate (76337-16-1)

Conditions	Yield
With pyridine In hexane at 21 - 22℃; for 16 - 18h;	83%

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → phytol phosphate

Conditions	Yield
With pyruvate kinase; phosphoenolpyruvic acid; undecaprenol kinase; ATP; 2-amino-2-hydroxymethyl-1,3-propanediol; magnesium chloride at 37℃; for 24h; pH=8; Kinetics; Enzymatic reaction;	82%

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) + benzoic acid anhydride (93-97-0) → (E/Z)-(all-rac)-phytyl benzoate (844467-81-8)

Conditions	Yield
With dmap In hexane at 23 - 24℃; for 20h;	76%

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → C20H39I

Conditions	Yield
With iodine; triphenylphosphine In diethyl ether at 20℃; for 4h;	70%

2,3-dimethyl-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-hydroquinone (868540-55-0) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → Acetic acid (2S,3S,4R,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[6-hydroxy-2,7,8-trimethyl-2-(4,8,12-trimethyl-tridecyl)-chroman-5-yl]-tetrahydro-pyran-3-yl ester (868602-40-8)

Conditions	Yield
With zinc(II) chloride	66%

3,5-dimethyl-2-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-hydroquinone (868540-58-3) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → Acetic acid (2S,3S,4R,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[6-hydroxy-2,5,7-trimethyl-2-(4,8,12-trimethyl-tridecyl)-3,4,4a,8a-tetrahydro-2H-chromen-8-yl]-tetrahydro-pyran-3-yl ester

Conditions	Yield
With zinc(II) chloride	63%

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) + 1,8-diazabicyclo[5.4.0]undec-7-ene (6674-22-2) + 2-cyanoethoxy-2-thiono-1,3,2-oxathiaphospholane (695179-28-3) → C20H41O3PS*C9H16N2*H3N

Conditions	Yield
Stage #1: 3,7,11,15-tetramethyl-2-hexadecen-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-cyanoethoxy-2-thiono-1,3,2-oxathiaphospholane In acetonitrile at 20℃; for 0.5h; Stage #2: With ammonium hydroxide In 1,4-dioxane; water at 20℃; for 48h;	62.2%

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → 6,10,14-Trimethyl-2-pentadecanon (502-69-2)

Conditions	Yield
With ozone In carbon dioxide at 20 - 140℃; under 45754.6 - 186769 Torr; for 0.458333h; Autoclave;	58%
With chloroethane beim Ozonisieren und Behandeln des entstandenen Ozonids mit Zinkstaub und Eisessig;
With chromium(VI) oxide; acetic acid unter Zusatz von Kaliumdisulfat;

N-acetylcystein (616-91-1) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → N-acetyl-S-phytyl-L-cysteine

Conditions	Yield
sulfuric acid at 120℃;	48%

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → 3,7,11,15-tetramethylhexadec-2-enal (120467-03-0) + [3-methyl-3-(4,8,12-trimethyl-tridecyl)-oxiranyl]-methanol (107438-44-8)

Conditions	Yield
With tert.-butylhydroperoxide; chromium(VI) oxide In dichloromethane for 5h; Ambient temperature;	A 10% B 20%

phthalic anhydride (85-44-9) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → neophytadiene (21980-71-2)

phthalic anhydride (85-44-9) + 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → phthalic acid monophytyl ester (142571-14-0)

Conditions	Yield
With benzene

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → 2-hexadecene, 3,7,11,15-tetramethyl-,[R-[R*,R*-(E)]]- (14237-73-1)

Conditions	Yield
With diethyl ether; ammonia; sodium

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → neophytadiene (21980-71-2)

Conditions	Yield
With phthalic anhydride; benzene

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → phytane (638-36-8)

Conditions	Yield
With diethyl ether; hydrogen; platinum
durch elektrolytische Reduktion;

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → (2E)-3,7,11,15-tetramethyl-2-hexadecene (532426-78-1)

Conditions	Yield
With hydrogen iodide Reduktion des entstandenen Jodids mit Zinkstaub;

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → 3,7,11,15-tetramethyl-2-hexadecen-1-oic acid (220904-31-4)

Conditions	Yield
With potassium hydrogensulfate; chromic acid; acetic acid

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → 3,7,11,15-tetramethyl-hexadec-2-en-1-ol; sodium-compound

Conditions	Yield
With diethyl ether; sodium

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) → Glycolaldehyde (141-46-8)

Conditions	Yield
With chloroethane durch Ozonisiation; Zersetzung des entstandenen Ozonids mit Zinkstaub in Aether+Eisessig+wenig Wasser;
With acetic acid ester durch Ozonisiation; Hydrierung des Ozonids in Gegenwart von Palladium-Calciumcarbonat;

3,7,11,15-tetramethyl-2-hexadecen-1-ol (7541-49-3) + 3,5-Dimethyl-4-hydroxy-thiophenol (43132-86-1) + acetic anhydride (108-24-7) → 6-Acetoxy-2,5,7-trimethyl-2-(4,8,12-trimethyl-tridecyl)-thiochroman

Conditions	Yield
With pyridine; formic acid

Upstream product

• 5492-31-9 3,7,11,15-tetramethyl-hexadec-2-enoic acid ethyl ester 
• 505-32-8 isophytol 
• 108-24-7 acetic anhydride 
• 76524-59-9 1-bromo-3,7,11,15-tetramethylhexadec-2-ene 
• 65592-98-5 1-chloro-3,7,11,15-tetramethylhexadec-2-ene 
• 76337-16-1 3,7,11,15-tetramethylhexadec-2-en-1-yl acetate 
• 3796-70-1 trans geranyl acetone 
• 5631-96-9 2-(2-chloroethoxy)-tetrahydro-2H-pyrane 
• 502-69-2 6,10,14-Trimethyl-2-pentadecanon 
• 1117-52-8 6,10,14-trimethyl-5,9,13-pentadecatriene-2-on 
• 107438-44-8 [3-methyl-3-(4,8,12-trimethyl-tridecyl)-oxiranyl]-methanol 
• 500996-28-1 geranylgeraniol-2,3-epoxide 
• 24034-73-9 Geranylgeraniol 
• 253686-88-3 (E)-3,7,11,15-tetramethylhexadec-2-en-1-ol 

Downstream Products

• 645-72-7 3,7,11,15-tetramethyl-hexadecanol 
• 14237-73-1 [R-[R*,R*-(E)]]-3,7,11,15-tetramethyl-2-hexadecene 
• 502-69-2 6,10,14-Trimethyl-2-pentadecanon 
• 638-36-8 phytane 
• 220904-31-4 3,7,11,15-tetramethyl-2-hexadecen-1-oic acid 
• 141-46-8 Glycolaldehyde 
• 85460-72-6 α-thiotocopherol acetate 
• 30220-53-2 3,7,11,15-tetramethylhexadecane-1,2-diol 
• 844467-81-8 (E/Z)-(all-rac)-phytyl benzoate 
• 81818-54-4 2-methyl-3-(3,7,11,15-tetramethyl-hexadec-2-enyl)-[1,4]naphthoquinone 
• 275820-16-1 C₃₇H₆₀O₃ 

Relevant articles and documents

Preparation method of phytol and intermediates thereof

The invention discloses a preparation method of phytol and intermediates thereof, which comprises the following steps: (1) carrying out esterification rearrangement reaction on isophytol and anhydrideunder the action of perchlorate to obtain phytol ester; and (2) carrying out transesterification on the phytol ester to obtain the phytol. According to the preparation method disclosed by the invention, the total molar yield of the phytol can be up to 88.1%, the generation of potassium acetate or sodium acetate waste solids caused by a potassium hydroxide or sodium hydroxide hydrolysis process isavoided by adopting an ester exchange process, three wastes are effectively controlled, and the method is green and environment-friendly.

Synthesis method and method for synthesizing plant alcohol, isoplant alcohol and geranyl geraniol by using intermediate farnesylacetone (by machine translation)

The invention relates to a synthesis method of intermediate farnesyl acetone and a method for synthesizing vitamin E, vitamin K1, vitamin K2 side chain isovegetable alcohol, plant alcohol and geranyl geraniol by using farnesyl acetone, and concretely relates to hydrogenation of 5 - farnesyl -2 - acetone and farnesyl acetone through three Grignard reaction to obtain plant ketone. The farnesyl acetone reacts with the vinyl chloride Grignard reagent to obtain geranyl linalool, the aromatic leaf-based geraniol is rearranged under acid catalysis, or farnesyl acetone is directly reacted with the hydroxyl-protected 2 - chloroethanol Grignard reagent to obtain geraniol. The plant alcohol is reacted with the vinyl chloride Grignard reagent to obtain the plant alcohol, and the plant alcohol is directly reacted with the hydroxyl-protected 2 - chloroethanol Grignard reagent to obtain the plant alcohol. The method has the advantages of cheap and easily available starting materials, short synthetic process steps, low product cost and the like. (by machine translation)