Welcome to LookChem.com Sign In|Join Free

Cas Database

7697-23-6

7697-23-6

Identification

Synonyms:2-Fluoro-4-MethylbenzoicAcid;2-Fluoro-4-methyl benzoic acid;2-Fluoro-p-toluic acid;Benzoic acid, 2-fluoro-4-methyl-;

Post Buying Request Now

Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi,Xn

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Fluoro-4-methylbenzoic Acid
  • Packaging:500mg
  • Price:$ 65
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Fluoro-4-methylbenzoic Acid >98.0%(GC)(T)
  • Packaging:1g
  • Price:$ 40
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Fluoro-4-methylbenzoic Acid >98.0%(GC)(T)
  • Packaging:5g
  • Price:$ 120
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Fluoro-4-methylbenzoic acid
  • Packaging:25 g
  • Price:$ 110
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Fluoro-4-methylbenzoic acid
  • Packaging:1 g
  • Price:$ 15
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Fluoro-4-methylbenzoic acid
  • Packaging:5 g
  • Price:$ 45
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Fluoro-4-methylbenzoic acid 98%
  • Packaging:5g
  • Price:$ 42
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Fluoro-4-methylbenzoic acid 98%
  • Packaging:25g
  • Price:$ 87
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:2-Fluoro-4-methylbenzoic Acid 97%
  • Packaging:5g
  • Price:$ 295
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:2-Fluoro-4-methylbenzoic Acid 97%
  • Packaging:1g
  • Price:$ 84
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 13 Articles be found

Chemical synthesis method of 4-fluoro-2-methyl benzoic acid

-

Page/Page column 4; 5, (2020/04/02)

The invention relates to a chemical synthesis method of 4-fluoro-2-methyl benzoic acid. According to the synthesis method, m-fluorotoluene and trichloroacetyl chloride are used as starting raw materials, and are subjected to a Friedel-Crafts acylation reaction under the catalytic action of anhydrous aluminum trichloride, hydrolysis and acidification are performed under an alkaline condition to obtain two isomers of 4-fluoro-2-methyl benzoic acid and 2-fluoro-4-methyl benzoic acid, and the isomers are separated through re-crystallizing to obtain the target product 4-fluoro-2-methylbenzoic acid.The method has the advantages of accessible raw materials, mild reaction conditions and low cost, and is suitable for industrial production.

Synthesis of aryl fluorides on a solid support and in solution by utilizing a fluorinated solvent

Doebele, Marion,Vanderheiden, Sylvia,Jung, Nicole,Braese, Stefan

supporting information; experimental part, p. 5986 - 5988 (2010/10/01)

(Figure Presented) F for fast: The perfluorinated solvent C 6F14 is the key to a new variant of the BalzSchiemann reaction for the synthesis of fluorinated arenes. Triazenes are converted into fluoroarenes under mild con-ditions on a support and in solution (see scheme). The method is straightforward and inexpensive, and yields previously difficult-to-prepare fluoroarenes in high purity.

New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists

Yea, Christopher M.,Allan, Christine E.,Ashworth, Doreen M.,Barnett, James,Baxter, Andy J.,Broadbridge, Janice D.,Franklin, Richard J.,Hampton, Sally L.,Hudson, Peter,Horton, John A.,Jenkins, Paul D.,Penson, Andy M.,Pitt, Gary R. W.,Rivière, Pierre,Robson, Peter A.,Rooker, David P.,Semple, Graeme,Sheppard, Andy,Haigh, Robert M.,Roe, Michael B.

scheme or table, p. 8124 - 8134 (2009/11/30)

Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney. The analogue of AVP, desmopressin, has proven an effective drug for diseases where a reduction of urine output is desired. However, its peptidic nature limits its bioavailability. We report herein the discovery of potent, nonpeptidic, benzylurea derived agonists of the vasopressin V2 receptor. We describe substitutions on the benzyl group to give improvements in potency and subsequent modifications to the urea end group to provide improvements in solubility and increased oral efficacy in a rat model of diuresis. The lead compound 20e (VA106483) is reported for the first time and has been selected for clinical development.

Process route upstream and downstream products

Process route

m-Fluorotoluene
352-70-5

m-Fluorotoluene

potassium <i>tert</i>-butylate
865-47-4

potassium tert-butylate

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 2.5h;
45%
carbon dioxide
124-38-9,18923-20-1

carbon dioxide

4-bromo-3-fluorotoluene
452-74-4

4-bromo-3-fluorotoluene

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
4-bromo-3-fluorotoluene; With ethyl bromide; magnesium; In tetrahydrofuran;
carbon dioxide;
34.9%
With n-butyllithium; In tetrahydrofuran; at -78 ℃;
4-bromo-3-fluorotoluene; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;
carbon dioxide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
m-Fluorotoluene
352-70-5

m-Fluorotoluene

trifluoroacetyl chloride
76-02-8

trifluoroacetyl chloride

4-fluoro-2-methylbenzoic acid
321-21-1

4-fluoro-2-methylbenzoic acid

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
m-Fluorotoluene; trifluoroacetyl chloride; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 - 10 ℃; Inert atmosphere;
With water; sodium hydroxide; for 1h;
94 g
C<sub>16</sub>H<sub>16</sub>N<sub>3</sub>O<sub>2</sub>Pol

C16H16N3O2Pol

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
With tetrafluoroboric acid diethyl ether; In tetradecafluorohexane; at 80 ℃; for 12h; Autoclave; solid phase reaction;
86%
4-Bromo-3-nitrotoluene
5326-34-1

4-Bromo-3-nitrotoluene

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: 84.9 percent / Fe; CH3COOH
2.1: HCl; NaBF4; NaNO2
2.2: 57.7 percent / Heating
3.1: 34.9 percent / C2H5Br; Mg / tetrahydrofuran
With hydrogenchloride; sodium tetrafluoroborate; ethyl bromide; iron; magnesium; acetic acid; sodium nitrite; In tetrahydrofuran; 2.2: Schiemann reaction;
2-bromo-5-methylaniline
53078-85-6

2-bromo-5-methylaniline

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: HCl; NaBF4; NaNO2
1.2: 57.7 percent / Heating
2.1: 34.9 percent / C2H5Br; Mg / tetrahydrofuran
With hydrogenchloride; sodium tetrafluoroborate; ethyl bromide; magnesium; sodium nitrite; In tetrahydrofuran; 1.2: Schiemann reaction;
4-methyl-2-nitroacetanilide
612-45-3

4-methyl-2-nitroacetanilide

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: 99.4 percent / Claisen's base
2.1: H2SO4; NaNO2
2.2: 51.8 percent / Cu2Br2
3.1: 84.9 percent / Fe; CH3COOH
4.1: HCl; NaBF4; NaNO2
4.2: 57.7 percent / Heating
5.1: 34.9 percent / C2H5Br; Mg / tetrahydrofuran
With hydrogenchloride; sodium tetrafluoroborate; ethyl bromide; Claisen's base; sulfuric acid; iron; magnesium; acetic acid; sodium nitrite; In tetrahydrofuran; 4.2: Schiemann reaction;
4-methyl-2-nitroaniline
89-62-3

4-methyl-2-nitroaniline

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: H2SO4; NaNO2
1.2: 51.8 percent / Cu2Br2
2.1: 84.9 percent / Fe; CH3COOH
3.1: HCl; NaBF4; NaNO2
3.2: 57.7 percent / Heating
4.1: 34.9 percent / C2H5Br; Mg / tetrahydrofuran
With hydrogenchloride; sodium tetrafluoroborate; ethyl bromide; sulfuric acid; iron; magnesium; acetic acid; sodium nitrite; In tetrahydrofuran; 3.2: Schiemann reaction;
2-fluoro-1,4-dimethylbenzene
696-01-5

2-fluoro-1,4-dimethylbenzene

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
With nitric acid;
carbon dioxide
124-38-9,18923-20-1

carbon dioxide

m-Fluorotoluene
352-70-5

m-Fluorotoluene

2-fluoro-4-methylbenzoic Acid
7697-23-6

2-fluoro-4-methylbenzoic Acid

Conditions
Conditions Yield
With potassium tert-butylate; tert.-butyl lithium; Yield given; Multistep reaction; 1.) THF, pentane, -75 deg C, 3 h;

Global suppliers and manufacturers

Global( 105) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:89
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:56
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 7697-23-6
Post Buying Request Now
close
Remarks: The blank with*must be completed