696-01-5

Basic information

• Product Name: 2-Fluoro-p-Xylene
• Synonyms: 1,4-Dimethyl-2-fluorobenzene
• CAS NO: 696-01-5
• Molecular Formula: C₈H₉F
• Molecular Weight: 124.16
• Mol File: 696-01-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: -6℃
• Boiling Point: 144.7℃
• Flash Point: 30.9℃
• Appearance: /
• Density: 0.983
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Fluoro-p-Xylene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-p-Xylene(696-01-5)
• EPA Substance Registry System: 2-Fluoro-p-Xylene(696-01-5)

Safety Data

• Hazardous Substances Data: 696-01-5(Hazardous Substances Data)

Usage

Description

2-Fluoro-p-Xylene, also known as 1,4-difluoro-2-methylbenzene, is an organic compound characterized by the chemical formula C8H9F2. It exists as a colorless liquid with a subtle aromatic scent. 2-Fluoro-p-Xylene is predominantly utilized as a crucial intermediate in the synthesis of various agrochemicals, pharmaceuticals, and organic compounds.

Uses

Used in Chemical Synthesis Industry:
2-Fluoro-p-Xylene is employed as a key intermediate for the production of a variety of chemical compounds. Its unique structure, featuring a fluorine atom and a methyl group attached to a benzene ring, makes it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-Fluoro-p-Xylene is used as a precursor in the synthesis of certain drugs. Its presence in the molecular structure can influence the pharmacokinetics and pharmacodynamics of the final drug product, potentially enhancing its therapeutic efficacy and selectivity.
Used in Agrochemical Industry:
2-Fluoro-p-Xylene also serves as an intermediate in the development of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can contribute to their effectiveness in controlling pests and weeds, thereby supporting agricultural productivity.
Safety Considerations:
Given its classification as a hazardous substance, 2-Fluoro-p-Xylene requires careful handling to avoid potential health risks, including skin and eye irritation. Additionally, due to its flammable nature, it is imperative to adhere to proper safety protocols during its use and storage to prevent accidents and ensure the well-being of individuals in proximity.

Upstream product

• 89-58-7 mononitro-p-xylene 
• 106-42-3 para-xylene 
• 95-78-3 2,5-Dimethylaniline 
• 75-89-8 2,2,2-trifluoroethanol 

Downstream Products

• 147542-00-5 4-(chloromethyl)-2-fluoro-1-methylbenzene 
• 147541-99-9 2-fluoro-4-methylbenzyl chloride 
• 127865-67-2 2-fluoro-1,4-dichloromethylbenzene 
• 118745-63-4 1-(bromomethyl)-2-fluoro-4-methylbenzene 
• 69857-34-7 (4-Cyanomethyl-2-fluoro-phenyl)-acetonitrile 
• 35335-08-1 1,4-bis(bromomethyl)-2,5-difluorobenzene 
• 73317-99-4 (4-Cyanomethyl-2,5-difluoro-phenyl)-acetonitrile 
• 452-94-8 2,5-difluoro-p-xylene 
• 1737-69-5 4-fluoro-2,5-dimethylaniline 
• 760987-97-1 (E,E)-1-fluoro-2,5-bis(3-methoxycarbonyl-4-hydroxystyryl)benzene 
• 760987-96-0 dimethyl 5,5'-[(1E,1'E)-(2-fluoro-1,4-phenylene)bis(ethene-2,1-diyl)]bis(2-methoxybenzoate) 
• 760987-95-9 [4-(diethoxy-phosphorylmethyl)-2-fluoro-benzyl]-phosphonic acid diethyl ester 
• 7697-23-6 2-fluoro-4-methylbenzoic Acid 
• 350-28-7 3-fluoro-4-methyl-benzoic acid 

Relevant articles and documents

Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques

Two styrylbenzene derivatives, (E,E)-1-fluoro-2,5-bis-(3-hydroxycarbonyl-4- hydroxy)styrylbenzene (FSB) and (E,E)-1-bromo-2,5-bis(3-hydroxycarbonyl-4- hydroxy)styrylbenzene-α,α′-13C2 ([ 13C]BSB), were synthesized for use as a histochemical stain to detect amyloid plaques of Alzheimer's disease (AD) brain sections. An analysis of fluorescence spectra demonstrated that FSB shows approximately twofold fluorescence intensity relative to the conventional styrylbenzene derivative, (E,E)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB). Moreover, FSB was found to stain amyloid plaques and neurofibrillary tangles of AD brains with greater fluorescence intensity and a lower level of background signals compared to BSB. These finding indicate that FSB can be an excellent fluorescent compound to label human amyloid lesions with high sensitivity and specificity. Because of the possession of a nuclide with a quantized angular momentum, both FSB and [13C]BSB are also potential contrast agents for magnetic resonance imaging to locate AD pathologies in vivo.

Novel process for generating useful electrophiles from common anions using Selectfluor fluorination agent

In the present work, the electrophile equivalents C1+, Br+, SCN+, and NO2+ are generated from their respective sodium, potassium, and in some cases ammonium salts (M+X-) by reaction with Selectfluor electrophilic fluorination agent in acetonitrile solution at room temperature. These generated electrophilic species subsequently react in situ with a variety of aromatic substrates containing one or more substituent groups including H, F, C1, CH3, COOH, C(O)CH3, NO2, and OR′ and NR′R″ where R′ and R″ are H or CH3. The resulting substitution products are, in most cases, isolable as pure compounds in high yield. Variations in the process include the use of other anions, electrophilic fluorination agents, and solvents.

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.