77034-33-4Relevant articles and documents
Multivalent manganese complex decorated amphiphilic dextran micelles as sensitive MRI probes
Wu, Changqiang,Li, Danyang,Yang, Li,Lin, Bingbing,Zhang, Houbing,Xu, Ye,Cheng, Zhuzhong,Xia, Chunchao,Gong, Qiyong,Song, Bin,Ai, Hua
supporting information, p. 1470 - 1473 (2015/03/04)
T1 contrast agents based on Mn(ii) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T1 relaxivity (13.3 Mn mmol-1 s-1) and better sensitivity than those of free Mn(ii) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg-1 BW). This journal is
Enantioselective synthesis of α-secondary and α-tertiary piperazin-2- Ones and piperazines by catalytic asymmetric allylic alkylation
Korch, Katerina M.,Eidamshaus, Christian,Behenna, Douglas C.,Stoltz, Brian M.,Nam, Sangkil,Horne, David
supporting information, p. 179 - 183 (2015/02/05)
The asymmetric palladium-catalyzed decarboxylative allylic alkylation of differentially N-protected piperazin-2- ones allows the synthesis of a variety of highly enantioenriched tertiary piperazine-2-ones. Deprotection and reduction affords the corresponding tertiary piperazines, which can be employed for the synthesis of medicinally important analogues. The introduction of these chiral tertiary piperazines resulted in imatinib analogues which exhibited comparable antiproliferative activity to that of their corresponding imatinib counterparts.
Base-promoted c→n acyl rearrangement: An unconventional approach to α-amino acid derivatives
Ugarriza, Iratxe,Uria, Uxue,Carrillo, Luisa,Vicario, Jose L.,Reyes, Efraim
supporting information, p. 11650 - 11654 (2014/10/15)
We have discovered that N-alkyl aminomalonates undergo a fast and selective intramolecular C→N acyl rearrangement reaction in the presence of a strong base, leading to N-protected glycinates in excellent yield. Moreover, the fact that the reaction proceeds through a nucleophilic enolate intermediate has been used for implementing a tandem rearrangement/alkylation sequence that has been applied to the preparation of synthetically relevant nonproteinogenic tertiary and quaternary N-alkyl α-amino acids in a very simple and reliable way.
Synthesis of non-natural cyclic amino acids from available unsaturated tertiary amines
Titanyuk,Beletskaya
experimental part, p. 1277 - 1281 (2010/12/19)
New approach is developed to the synthesis of cyclic amino acids derivatives. Unsaturated tertiary amines react with ethyl diazoacetate under the catalysis by copper catalyst Cu(F3acac)2 leading to the formation of products of [2,3]-sigmatropic rearrangement which via the metathesis of double bonds undergo a ring closure. The subsequent hydrogenation of compounds obtained furnished esters of 6- and 7-membered cyclic α-amino acids. Besides the racemic also optically active compounds were obtained, in particular, esters of (R)- and (S)-pipecolic acid.
A concise synthesis of (±) and a total synthesis of (+)-epiquinamide
Tong, Sok Teng (Amy),Barker, David
, p. 5017 - 5020 (2007/10/03)
A total synthesis of the quinolizidine alkaloid (+)-epiquinamide 1 has been achieved starting from (-)-pipecolinic acid 3. The key step is the highly diastereoselective addition of a TBDMS-protected propargyl alcohol to a chiral aldehyde derived from 3 to give erythro alkynol 19, which is then easily transformed into the desired bicyclic skeleton.
Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase
-
, (2008/06/13)
Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
Diastereoselectivity and assignment of absolute stereochemistry in the aza-Diels-Alder reaction of a sulfonylimino acetate with 1-methoxy-3-trimethylsilyloxybuta-1,3-diene
McFarlane, Andrew K.,Thomas Gareth,Whiting, Andrew
, p. 2803 - 2810 (2007/10/02)
N-imine 1b generated in situ from the corresponding brominated glycinate 4b reacts with Davishefsky's diene under thermal conditions to give a high yield of diastereoisomeric Diels-Alder adducts 7b and 6b in a 2.04:1 ratio.
Thienoquinolizidinones. Synthesis and Rearrangement into New Piperidino or diazepinones Fused to a Thiophene Ring
Marchalin, Stefan,Decroix, Bernard
, p. 495 - 500 (2007/10/02)
A convenient route to thienoquinolizidinones is described starting from ethyl pipecolinate and suitable halogenomethylthiophenes or 3-chloromethylbenzothiophene.The Schmidt reaction and the Beckmann rearangement of oximes of these ketones led to piperidino or diazepines fused to a thiophene ring.
