15932-71-5

Basic information

• Product Name: 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI)
• Synonyms: 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI);2H-Pyrido[1,2-a]pyrazin-1(6H)-one, hexahydro-
• CAS NO: 15932-71-5
• Molecular Formula: C₈H₁₄N₂O
• Molecular Weight: 154.212
• Product Categories: PIPERIDINE
• Mol File: 15932-71-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 329.5°Cat760mmHg
• Flash Point: 153.1°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 0.000177mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI)(15932-71-5)
• EPA Substance Registry System: 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI)(15932-71-5)

Safety Data

• Hazardous Substances Data: 15932-71-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H14N2O/c11-8-7-3-1-2-5-10(7)6-4-9-8/h7H,1-6H2,(H,9,11)

Upstream product

• 4043-87-2 pipecolic Acid 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 77034-33-4 ethyl piperidine-2-carboxylate hydrochloride 
• 151-56-4 ethyleneimine 
• 2459-07-6 methyl pyridine-2-carboxylate 
• 15862-72-3 ethyl pipecolate 
• 139579-84-3 1-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-piperidine-2-carboxylic acid ethyl ester 

Downstream Products

• 50369-64-7 1,3,4,6,7,8-hexahydro-2H-pyrido<1,2-a>pyrazin-1-one 
• 4430-75-5 octahydro-1H-pyrido[1,2-a]pyrazine 
• 88327-90-6 2-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-hexahydro-pyrido[1,2-a]pyrazin-1-one 
• 88327-88-2 4-ethyl-1,4-diazabicyclo<4.4.0>decan-5-one 
• 915723-08-9 2-(4-nitrophenyl)octahydro-2H-pyrido[1,2-a]pyrazine 
• 915722-90-6 4-(octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)phenylamine 

Relevant articles and documents

Enantioselective synthesis of α-secondary and α-tertiary piperazin-2- Ones and piperazines by catalytic asymmetric allylic alkylation

The asymmetric palladium-catalyzed decarboxylative allylic alkylation of differentially N-protected piperazin-2- ones allows the synthesis of a variety of highly enantioenriched tertiary piperazine-2-ones. Deprotection and reduction affords the corresponding tertiary piperazines, which can be employed for the synthesis of medicinally important analogues. The introduction of these chiral tertiary piperazines resulted in imatinib analogues which exhibited comparable antiproliferative activity to that of their corresponding imatinib counterparts.

2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use

The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, and for prostaglandin-E2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal, and a method for treating prostaglandin-E2 mediated diseases in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.