85068-36-6

Basic information

• Product Name: 2,5-DIFLUOROBENZOPHENONE
• Synonyms: Methanone, (2,5-difluorophenyl)phenyl-;2,5-DIFLUOROBENZOPHENONE;(2,5-DIFLUORO-PHENYL)-PHENYL-METHANONE;2,5-Difluorobenzophenone, 97+%;2,5-Difluorobenzophenone 97%;(2,5-Difluorophenyl)phenyl ketone
• CAS NO: 85068-36-6
• Molecular Formula: C₁₃H₈F₂O
• Molecular Weight: 218.2
• EINECS: 285-298-2
• Product Categories: Miscellaneous;Fluorine series
• Mol File: 85068-36-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 120 °C
• Flash Point: >110°C
• Appearance: /
• Density: 1.262
• Vapor Pressure: 0.000109mmHg at 25°C
• Refractive Index: 1.5693
• BRN: 4417185
• CAS DataBase Reference: 2,5-DIFLUOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIFLUOROBENZOPHENONE(85068-36-6)
• EPA Substance Registry System: 2,5-DIFLUOROBENZOPHENONE(85068-36-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 85068-36-6(Hazardous Substances Data)

Usage

General Description

2,5-Difluorobenzophenone is a chemical compound that belongs to the benzophenone family, which is widely used in the production of various pharmaceuticals, perfumes, and other industrial products. It is a white crystalline solid with a molecular formula C13H8F2O and a molecular weight of 220.2 g/mol. 2,5-DIFLUOROBENZOPHENONE is commonly used as a photoinitiator in UV-curing applications, as well as a building block in the synthesis of organic compounds. Its unique chemical structure and properties make it a valuable ingredient in the manufacturing of specialty chemicals and polymers. Additionally, it is classified as a low to moderate health hazard with mild skin and eye irritation potential.

InChI:InChI=1/C13H8F2O/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H

Upstream product

• 540-36-3 para-difluorobenzene 
• 98-88-4 benzoyl chloride 
• 98-80-6 phenylboronic acid 
• 408492-25-1 2-(2,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 100-52-7 benzaldehyde 
• 64248-64-2 2,5-difluorobenzonitrile 
• 80-17-1 benzenesufonyl hydrazide 
• 63468-90-6 phenylglyoxylic acid potassium salt 
• 201230-82-2 carbon monoxide 
• 211512-93-5 Trifluoro-methanesulfonic acid 2,5-difluoro-phenyl ester 
• 108-86-1 bromobenzene 
• 1421364-33-1 (2,5-difluorophenyl)diphenylmethanol 
• 119-61-9 benzophenone 

Downstream Products

• 57614-63-8 5-Fluoro-3-phenyl-1H-indazole 
• 88499-59-6 N₂-<(2,5-difluorophenyl)phenylmethylene>-N-methylhydrazinecarbothioamide 
• 1421364-33-1 (2,5-difluorophenyl)diphenylmethanol 
• 119-61-9 benzophenone 
• 1606178-15-7 (5-fluoro-2-(furan-2-yl)phenyl)(phenyl)methanone 
• 1606178-16-8 (2-benzyl-5-fluorophenyl)(phenyl)methanone 
• 4044-60-4 2,5-dimethylbenzophenone 
• 33184-52-0 (5-fluoro-2-methylphenyl)(phenyl)methanone 
• 1606178-14-6 (4-fluoro-4'-methylbiphenyl-2-yl)(phenyl)methanone 
• 1569280-41-6 C₁₉H₁₄FN₃O₂S 
• 1204771-72-1 C₁₇H₁₀FN₃O₂S 
• 1220532-00-2 C₁₇H₁₂FNO₃ 
• 1227300-72-2 C₂₁H₁₂FN 
• 300350-05-4 4-fluoro-2-benzoylthiophenol 

Relevant articles and documents

Photo-induced oxidative cleavage of C-C double bonds of olefins in water

The carbonyl compounds, synthesized by the oxidative cleavage of their corresponding olefins, are of great significance in organic synthesis, especially aryl ketones. We have developed a gentle and effective protocol, using acid red 94 as the organic metal-free photocatalyst, O2 as the oxidant, and water as the solvent. Under visible light irradiation, aryl ketone derivatives were obtained in moderate to excellent yields, showing good economic and environmental advantages.

Preparation method of aromatic ketone

The invention discloses a preparation method of aromatic ketone. Under the effects of a palladium catalyst and a nitrogen-containing ligand, nitrile compounds and arylsulfonylhydrazide take desulfurization addition reaction in an organic solvent; after the reaction is completed, post treatment is performed to obtain aromatic ketone. The reaction is applicable to aromatic nitrile compounds, and isalso applicable to aliphatic nitrile compounds; the reaction realizes the wide substrate applicability and functional group tolerance; the potential application value is realized in the aspect of aryl-carbonyl building.

Pd(II)-Catalyzed Denitrogenative and Desulfinative Addition of Arylsulfonyl Hydrazides with Nitriles

A Pd(II)-catalyzed denitrogenative and desulfinative addition of arylsulfonyl hydrazides with nitriles has been successfully achieved under mild conditions. This transformation is a new method for the addition reaction to nitriles with arylsulfonyl hydrazides as arylating agent, thus providing an alternative synthesis of aryl ketones. The reported addition reaction is tolerant to many common functional groups, and works well in the presence of electron-donating and electron-withdrawing substituents. Notably, the reported denitrogenative and desulfinative addition was also appropriate for alkyl nitriles, making this newly developed transformation attractive.