85331-33-5Relevant articles and documents
Synthesis method of 3, 5-dichloro-2-cyanopyridine
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Paragraph 0041; 0045-0047; 0051-0053; 0057-0058, (2019/12/09)
The invention provides a synthesis method of 3, 5-dichloro-2-cyanopyridine. The method includes the steps of: 1) in the presence of a solvent, mixing 2, 3, 5-trichloropyridine with a fluoride for reaction to obtain 3, 5-dichloro-2-fluoropyridine; and 2) mixing the 3, 5-dichloro-2-fluoropyridine prepared in step 1) with a catalyst and a cyanide salt for reaction to obtain 3, 5-dichloro-2-cyanopyridine. The method provided by the invention uses sodium cyanide, potassium cyanide or other cheap and easily available cyanide salts as the cyaniding reagent with a dosage far lower than that of the existing method, and can acquire the target product with high yield and high content, thereby greatly reducing the production cost, also greatly reducing the production of wastewater in the three wastes,and being an efficient and environment-friendly production method of 3, 5-dichloro-2-cyanopyridine.
Medicaments against viral diseases
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Page 8, (2010/02/05)
Novel dihydropyrimidines and combinations thereof with other antiviral agents, suitable for combating HBV infections.
Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds
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, (2008/06/13)
The present invention relates to a compound of the formula STR1 and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 adrenoreceptors and tr