85386-94-3

Basic information

• Product Name: 2-CHLORO-3-FLUOROPYRIDINE N-OXIDE
• Synonyms: 2-CHLORO-3-FLUOROPYRIDINE 1-OXIDE;2-CHLORO-3-FLUOROPYRIDINE N-OXIDE;2-Chlor-3-fluorpyridin-1-oxide;2-chloro-3-fluoro-1-oxidopyridin-1-ium;2-chloro-3-fluoropyridine1-oxide(WXFC0455)
• CAS NO: 85386-94-3
• Molecular Formula: C₅H₃ClFNO
• Molecular Weight: 147.53
• Mol File: 85386-94-3.mol

Chemical Properties

• Boiling Point: 317.1 °C at 760 mmHg
• Flash Point: 145.6 °C
• Appearance: /
• Density: 1.41 g/cm³
• PKA: -1.34±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-3-FLUOROPYRIDINE N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-FLUOROPYRIDINE N-OXIDE(85386-94-3)
• EPA Substance Registry System: 2-CHLORO-3-FLUOROPYRIDINE N-OXIDE(85386-94-3)

Safety Data

• Hazardous Substances Data: 85386-94-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-3-fluoropyridine N-oxide serves as a key intermediate in the production of various drugs, playing a crucial role in the development of new pharmaceuticals. Its unique structure allows for the creation of molecules with specific therapeutic properties, contributing to advancements in medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 2-Chloro-3-fluoropyridine N-oxide is utilized for the synthesis of pesticides and other crop protection agents. Its incorporation into these products enhances their effectiveness in protecting crops from pests and diseases, thereby supporting agricultural productivity.
Used in Research and Development:
2-Chloro-3-fluoropyridine N-oxide is also employed as a valuable research tool in both the medical and agricultural fields. It aids scientists in understanding the mechanisms of action of various compounds and in the discovery of new therapeutic agents and agrochemicals, driving innovation and progress in these sectors.

Upstream product

• 17282-04-1 2-chloro-3-fluoropyridine 
• 462-08-8 pyridin-3-ylamine 
• 6298-19-7 2-chloro-3-aminopyridine 

Downstream Products

• 101664-60-2 2-chloro-3-fluoro-6-nitro-pyridine-N-oxide 
• 101664-56-6 2-Chlor-3-fluor-4-nitropyridin-1-oxid 
• 109613-93-6 3,4-dimethoxypyridine 
• 101664-59-9 2-chloro-3,4-dimethoxypyridine 
• 101664-55-5 3,3',4,4'-tetramethoxy-2,2'-bipyridine 
• 109613-90-3 2-chloro-3-fluoro-4-nitropyridine 
• 72016-31-0 orelline 
• 37338-80-0 3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide 
• 85386-95-4 2-(1-Piperazinyl)-3-fluoropyridine N-oxide 

Relevant articles and documents

Syntheses of Hydroxylated Bipyridines, I. - Orellanine, the Poison of a Toadstool

Two syntheses of orellanine, -3,3',4,4'-tetrol-1,1'-dioxide (5b), are developed which comprise 10 or 11 steps, respectively.The chemical reactions of 5b with diazomethane and on UV irradiation are described.

SYNTHESIS OF ORELLANINE, THE LETHAL POISON OF A TOADSTOOL

A ten step synthesis of the structure of orellanine, 3,3',4,4'- hydroxy-2,2'-bipyridyl-bis-N-oxide (1a), is described which proves the identity of the natural product.

1-(3-HALO-2-PYRIDINYL) PIPERAZINE

1-(3-Halo-2-pyridinyl)piperazine and its acid addition salts are selective α 2-adrenergic receptor antagonists and thereby useful as antidepressant agents and for treating sedation caused by antihypertensive therapy.