866252-52-0 Usage
General Description
4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate is a chemical compound with the molecular formula C11H15F3O5SSi. It is a derivative of phenyl trifluoromethanesulfonate, containing two methoxy groups and a trimethylsilyl group attached to the phenyl ring. 4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate is often used as a reagent in organic synthesis to introduce the triflate group to nucleophiles, facilitating various chemical reactions such as substitution, elimination, and palladium-catalyzed cross-coupling reactions. It is a colorless liquid and is handled and stored under inert gas conditions due to its sensitivity to air and moisture. 4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate is commonly used in pharmaceutical research and other industries for the synthesis of complex organic molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 866252-52-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,6,2,5 and 2 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 866252-52:
(8*8)+(7*6)+(6*6)+(5*2)+(4*5)+(3*2)+(2*5)+(1*2)=190
190 % 10 = 0
So 866252-52-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H17F3O5SSi/c1-18-8-6-10(20-21(16,17)12(13,14)15)11(22(3,4)5)7-9(8)19-2/h6-7H,1-5H3
866252-52-0Relevant articles and documents
Trifluoromethyl aryl sulfonates (TFMS): An applicable trifluoromethoxylation reagent
Lei, Meng,Miao, Hang,Wang, Xueyuan,Zhang, Wen,Zhu, Chengjian,Lu, Xiaqiang,Shen, Jian,Qin, Yanru,Zhang, Haoyang,Sha, Sijia,Zhu, Yongqiang
, p. 1389 - 1392 (2019/04/30)
Fluorine is probably another favorite hetero-atom for incorporation into small molecules after nitrogen. Among many fluorine-containing groups, trifluoromethyl aryl ethers (ArOCF3) have unique properties in drug design and are difficult to be synthesized, and many different methods were developed to prepare them. A novel one-pot synthesis of o-iodine-aryl trifluoromethyl ethers (ArOCF3I) was described by the reaction of trifluoromethoxylation and iodination with trifluoromethyl aryl sulfonates (TFMS) in this manuscript. The reaction conditions were optimized by screening different solvents, crown ethers, substrates and the ratios and the yields of products were in moderate to high yields (up to 86%).
Synthesis method of calmodulin inhibitor for treating brain-derived diseases
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Paragraph 0027; 0028; 0029, (2017/08/29)
The invention discloses a synthesis method of a calmodulin inhibitor for treating brain-derived diseases and belongs to the technical field of synthesis of chemicals. The technical scheme is characterized in that a synthetic route of the synthesis method
