91240-51-6

Basic information

• Product Name: (S)-tert-butyl 2,5-dioxotetrahydrofuran-3-ylcarbamate
• CAS NO: 91240-51-6
• Molecular Weight: 215.206
• Mol File: 91240-51-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 2,5-dioxotetrahydrofuran-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 2,5-dioxotetrahydrofuran-3-ylcarbamate(91240-51-6)
• EPA Substance Registry System: (S)-tert-butyl 2,5-dioxotetrahydrofuran-3-ylcarbamate(91240-51-6)

Safety Data

• Hazardous Substances Data: 91240-51-6(Hazardous Substances Data)

Usage

General Description

(S)-tert-butyl 2,5-dioxotetrahydrofuran-3-ylcarbamate is a chemical compound that belongs to the class of carbamate derivatives. It is a potent inhibitor of cholinesterases and has been studied for its potential use in the treatment of neurological disorders such as Alzheimer's disease. (S)-tert-butyl 2,5-dioxotetrahydrofuran-3-ylcarbamate has also demonstrated antifungal activity against various fungal species, making it a promising candidate for the development of new antifungal drugs. Additionally, it has shown potential as a key intermediate in the synthesis of various pharmaceutical compounds. However, further research is needed to fully understand its pharmacological properties and potential applications.

Upstream product

• 56-84-8 L-Aspartic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13726-67-5 Boc-Asp-OH 
• 693-13-0 diisopropyl-carbodiimide 

Downstream Products

• 1360817-30-6 C₃₀H₂₉FN₄O₅S 
• 1360817-31-7 C₃₀H₂₉FN₄O₅S 
• 40856-59-5 tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate 
• 104227-71-6 N-[(3S)-tetrahydro-5-oxo-3-furanyl]carbamic acid-1,1-dimethylethyl ester 
• 117752-82-6 (S)-β-amino-γ-butyrolactone hydrochloride 
• 130052-03-8 2-tert-butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2-cyano-ethyl) ester 
• 130052-02-7 Boc-Asp(OChx)-OCet 
• 73821-95-1 Boc-Asp(O-cyclohexyl)-OH 
• 1676-90-0 Boc-Asp(OtBu)-OH 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 83345-44-2 3-tert-butoxycarbonylamino-4-hydroxy-butyric acid 
• 221106-60-1 (S)-3-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsiloxy)butyric acid benzyl ester 
• 129046-87-3 fluoren-9-ylmethyl N-tert-butyloxycarbonyl-L-aspartate 
• 56-84-8 L-Aspartic acid 

Relevant articles and documents

Thermal Syntheses of Polypeptides from N-Boc-Amino Acid(Aspartic Acid,β-Aminoglutaric Acid) Anhydrides

N-t-Butyloxycarbonyl-amino acid(aspartic acid:Asp, glutamic acid:Glu, β-aminoglutaric acid: β-Agl)anhydrides were deprotected upon heating at temperatures slightly higher than the melting points of these compounds and polypeptides were synthesized easily in high yield.

Polypeptide formation by heating N-t-butyloxycarbonyl acidic amino acid derivatives

An acid labile N-protecting group for amino acids, t-butyloxycarbonyl (Boc) group has deprotected at elevated temperatures. The study describes an application of the lability on heating to synthesis of polypeptides from acidic amino acids. t-Butyloxycarbonyl-acidic amino acids (aspartic acid, glutamic acid and β-aminoglutaric acid) and their anhydrides were heated at the higher temperatures than their melting points. Anhydrides of t-butyloxycarbonyl-aspartic acid and t-butyloxycarbonyl-β-aminoglutaric acid gave polypeptides. Thermal analyses of the substrates clarified the pathway of the polypeptide formation.

Bronsted base-assisted boronic acid catalysis for the dehydrative intramolecular condensation of dicarboxylic acids

Bronsted base-assisted boronic acid catalysis for the dehydrative self-condensation of carboxylic acids is described. Arylboronic acid bearing bulky (N,N-dialkylamino)methyl groups at the 2,6-positions can catalyze the intramolecular dehydrative condensation of di-and tetracarboxylic acids. This is the first successful method for the catalytic dehydrative self-condensation of carboxylic acids.(Figure Presented)