92614-86-3Relevant articles and documents
Bifunctional Fe(ii) spin crossover-complexes based on ω-(1: H -tetrazol-1-yl) carboxylic acids
Zeni, Willi,Seifried, Marco,Knoll, Christian,Welch, Jan M.,Giester, Gerald,St?ger, Berthold,Artner, Werner,Reissner, Michael,Müller, Danny,Weinberger, Peter
, p. 17183 - 17193 (2020/12/28)
To increase the supramolecular cooperativity in Fe(ii) spin crossover materials based on N1-substituted tetrazoles, a series of ω-(1H-tetrazol-1-yl) carboxylic acids with chain-lengths of C2-C4 were synthesized. Structural characterization confirmed the formation of a strong hydrogen-bond network, responsible for enhanced cooperativity in the materials and thus largely complete spin-state transitions for the ligands with chain lenghts of C2 and C4. To complement the structural and magnetic investigation, electronic spectroscopy was used to investigate the spin-state transition. An initial attempt to utilize the bifunctional coordination ability of the ω-(1H-tetrazol-1-yl) carboxylic acids for preparation of mixed-metallic 3d-4f coordination polymers resulted in a novel one-dimensional gadolinium-oxo chain system with the ω-(1H-tetrazol-1-yl) carboxylic acid acting as μ2-η2:η1 chelating-bridging ligand.
Synthesis of tetrazole analogues of phosphonohydroxamic acids: An attempt to improve the inhibitory activity against the DXR
Nguyen-Trung, Anh Thu,Tritsch, Denis,Grosdemange-Billiard, Catherine,Rohmer, Michel
supporting information, p. 1643 - 1647 (2013/04/10)
This work is focused on the design of new antimicrobial drugs and on the development of lipophilic inhibitors of the DXR, the second enzyme of the MEP pathway for the biosynthesis of isoprene units in most bacteria, by replacing the phosphonate group of fosmidomycin derivatives by a tetrazoyl moiety capable of multiple hydrogen bonding. The N- and C-substituted tetrazole analogues of phosphonohydroxamate inhibitors were synthesized and tested on the DXR of Escherichia coli. This work points out the hypothesis that the phosphonate/phosphate recognition site might be too rigid to accommodate other functional groups.
SYNTHESIS OF 1-SUBSTITUTED TETRAZOLES BY HETEROCYCLIZATION OF PRIMARY AMINES, ORTHOFORMIC ESTER, AND SODIUM AZIDE
Gaponik, P. N.,Karavai, V. P.,Grigor'ev, Yu. V.
, p. 1255 - 1258 (2007/10/02)
It has been shown that the reaction of heterocyclization of primary amines with orthoformic acid and sodium azide in acetic acid has a rather general character and is a convenient method for the synthesis of 1-substituted tetrazoles.On the basis of experimental data, a probable reaction mechanism is proposed.