93204-37-6

Basic information

• Product Name: Z-D-SER(TBU)-OME
• Synonyms: N-ALPHA-CARBOBENZOXY-D-SERINE T-BUTYL ETHER METHYL ESTER;Z-D-SER(TBU)-OME;Z-D-SERINE(TBU)-OME;Z-O-T-BUTYL-D-SERINE METHYL ESTER;6-BROMO-3-CHLOROTOLUENE 97%;O-(1,1-Dimethylethyl)-N-[(Phenylmethoxy)Carbonyl]-D-Serine Methyl Ester;Z-O-tert-butyl-D-serine methyl ester≥ 97% (HPLC)
• CAS NO: 93204-37-6
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.36
• Mol File: 93204-37-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Z-D-SER(TBU)-OME(CAS DataBase Reference)
• NIST Chemistry Reference: Z-D-SER(TBU)-OME(93204-37-6)
• EPA Substance Registry System: Z-D-SER(TBU)-OME(93204-37-6)

Safety Data

• Hazardous Substances Data: 93204-37-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 154632-86-7 O₁-benzyl-O₂-methyl-(2R)-aziridine-1,2-dicarboxylate 
• 75-65-0 tert-butyl alcohol 
• 93204-36-5 (R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxypropanoate 
• 115-11-7 isobutene 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 65806-90-8 (R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)propanoic acid 
• 1222102-51-3 (R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(t-butoxymethyl)piperazin-2-one L-tartrate 
• 1246961-49-8 (R)-methyl 2-(2-(benzyloxycarbonylamino)ethylamino)-3-t-butoxypropanoate 
• 1246961-50-1 (R)-3-(t-butoxymethyl)piperazine-2-one di-p-toluoyl-L-tartrate 

Relevant articles and documents

Aryl substituted aminotetrahydropyran compound and use thereof

The invention relates to an aryl substituted aminotetrahydropyran compound and use thereof, and further relates to a pharmaceutical composition comprising the compound. The compound or pharmaceuticalcomposition provided by the invention can be used as a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE

The present invention relates to an improved method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention allows reduction of production costs by reacting low cost reagents, improves yield and is adaptable for mass production.

Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes

A series of β-amino amide containing substituted piperazine-2-one derivatives was synthesized and evaluated as inhibitors of dipeptidyl pepdidase-4 (DPP-4) for the treatment of type 2 diabetes. As results of intensive SAR study of the series, (R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)- butanoyl]-3-(t-butoxymethyl)-piperazin-2-one (DA-1229) displayed potent DPP-4 inhibition pattern in several animal models, was selected for clinical development.

DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING A DIABETES OR AN OBESITY

The present invention provides a novel heterocyclic compound containing a beta-amino group, a method for preparing the same, and a pharmaceutical composition comprising the same heterocyclic compound or a pharmaceutically acceptable salt thereof as an act