95652-81-6

Basic information

• Product Name: 6-chloro-2-methoxynicotinaldehyde
• Synonyms: 6-chloro-2-methoxynicotinaldehyde;6-CHLORO-2-METHOXY-PYRIDINE-3-CARBALDEHYDE;6-Chloro-2-methoxy-3-pyridinecarbaldehyde;6-Chloro-2-methoxypyridine-3-carboxaldehyde
• CAS NO: 95652-81-6
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.582
• Mol File: 95652-81-6.mol

Chemical Properties

• Melting Point: 78-81°C
• Boiling Point: 90 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.317±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.59±0.10(Predicted)
• CAS DataBase Reference: 6-chloro-2-methoxynicotinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-methoxynicotinaldehyde(95652-81-6)
• EPA Substance Registry System: 6-chloro-2-methoxynicotinaldehyde(95652-81-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 95652-81-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-2-methoxynicotinaldehyde is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique chemical structure allows it to be a key component in the development of new pharmaceutical compounds.

Upstream product

• 124-41-4 sodium methylate 
• 40381-90-6 2,6-dichloro-3-pyridinecarbonitrile 
• 67-56-1 methanol 
• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 

Downstream Products

• 1585241-94-6 C₂₆H₃₀N₂O₁₀ 
• 86630-09-3 Acromelic acid A 
• 1585241-73-1 (2S,3S,4S)-1-((benzyloxy)carbonyl)-3-(2-methoxy-2-oxoethyl)-4-(2-methoxy-6-(methoxycarbonyl)pyridin-3-yl)pyrrolidine-2-carboxylic acid 
• 1585241-72-0 C₂₄H₂₆N₂O₉ 
• 1585241-82-2 (2R,3S,4S)-1-benzyl 2-tert-butyl 3-(2-methoxy-2-oxoethyl)-4-(2-methoxy-6-(methoxycarbonyl)pyridin-3-yl)pyrrolidine-1,2-dicarboxylate 
• 1585241-70-8 C₃₂H₃₆N₂O₇ 
• 1585241-69-5 (S)-5-benzhydryl 1-tert-butyl 3-((S)-1-(2-methoxy-6-(methoxycarbonyl)pyridin-3-yl)-2-nitroethyl)-2-oxopentanedioate 
• 401792-87-8 methyl 5-formyl-6-methoxy-2-pyridinecarboxylate 

Relevant articles and documents

Transformations of trichloromethyl groups during reactions of 3-trichloromethylpyridines with methoxide

When methoxide ion attacks an unsubstituted 2- or 6-position of a 3-trichloromethylpyridine, a hydrogen shift leads to a methoxy-substituted 3-dichloromethylpyridine. Further reaction of the dichloromethyl group with methoxide gives the corresponding acetal. This type of reaction has been applied to several chlorinated 3-trichloromethylpyridines and to 3- trichloromethylpyridine itself; a convenient synthesis of the latter is described.

ABNORMAL NUCLEOPHILIC SUBSTITUTION OF 3-TRICHLOROMETHYLPYRIDINES BY METHOXIDE

3-Trichloromethylpyridine and its α-chlorinated derivatives behave as ambident electrophilic substrates towards methoxide which attacks an α-position and the trichloromethyl group.