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98-97-5

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98-97-5 Usage

Chemical Properties

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Uses

Different sources of media describe the Uses of 98-97-5 differently. You can refer to the following data:
1. Pyrazinecarboxylic Acid is a very potent urate retaining drug. Pyrazinecarboxylic Acid is a metabolite of the antibacterial agent Pyrazinamide (P840600).
2. Labelled analogue of Pyrazinecarboxylic Acid, a very potent urate retaining drug. Pyrazinecarboxylic Acid is a metabolite of the antibacterial agent Pyrazinamide (P840600).

Definition

ChEBI: The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.

Synthesis Reference(s)

The Journal of Organic Chemistry, 40, p. 1187, 1975 DOI: 10.1021/jo00896a050

Flammability and Explosibility

Notclassified

Purification Methods

It crystallises from water. The methyl ester has m 62o (from pet ether). [Sauville & Spoerri J Am Chem Soc 63 3153 1941, Beilstein 25 III/IV 771.]

Check Digit Verification of cas no

The CAS Registry Mumber 98-97-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 98-97:
(4*9)+(3*8)+(2*9)+(1*7)=85
85 % 10 = 5
So 98-97-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)

98-97-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A13363)  Pyrazine-2-carboxylic acid, 99%   

  • 98-97-5

  • 25g

  • 330.0CNY

  • Detail
  • Alfa Aesar

  • (A13363)  Pyrazine-2-carboxylic acid, 99%   

  • 98-97-5

  • 100g

  • 1148.0CNY

  • Detail
  • Alfa Aesar

  • (A13363)  Pyrazine-2-carboxylic acid, 99%   

  • 98-97-5

  • 500g

  • 5155.0CNY

  • Detail
  • Sigma-Aldrich

  • (82611)  Pyrazinecarboxylicacid  purum, ≥98.0% (T)

  • 98-97-5

  • 82611-25G

  • 423.54CNY

  • Detail
  • Aldrich

  • (P56100)  Pyrazinecarboxylicacid  99%

  • 98-97-5

  • P56100-25G

  • 415.35CNY

  • Detail
  • Aldrich

  • (P56100)  Pyrazinecarboxylicacid  99%

  • 98-97-5

  • P56100-100G

  • 1,434.42CNY

  • Detail

98-97-5Synthetic route

2,3-dicarboxypyrazine
89-01-0

2,3-dicarboxypyrazine

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
With sulfuric acid; acetic acid for 2h; Heating;85%
at 210℃; under 3 - 4 Torr;
With water; toluene
With nitrobenzene
2-Methylpyrazine
109-08-0

2-Methylpyrazine

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
With 18-crown-6 ether; potassium tert-butylate; oxygen In 1,2-dimethoxyethane at 60℃; under 3800 Torr; for 24h;64%
In water Ambient temperature; electrochemical oxidation on activated nickel hydroxide anode;60%
With selenium(IV) oxide In acetic acid for 0.0833333h; Heating; microwave;50%
2,5-dimethyl-pyrazine
123-32-0

2,5-dimethyl-pyrazine

A

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

B

2-methylpyrazin-5-carboxylic acid
5521-55-1

2-methylpyrazin-5-carboxylic acid

C

2,5-pyrazinedicarboxylic acid
122-05-4

2,5-pyrazinedicarboxylic acid

Conditions
ConditionsYield
With cobalt(II) nitrate In water Ambient temperature; electrochemical oxidation on activated nickel hydroxide anode;A 2%
B 42%
C 3%
In water Ambient temperature; electrochemical oxidation on activated nickel hydroxide anode;A 12%
B 22%
C 5%
With chromium(III) nitrate In diethyl ether Product distribution; Ambient temperature; electrochemical oxidation; var. additives, var. reaction time vs. conversion;
2-ethylpyrazine
13925-00-3

2-ethylpyrazine

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
With potassium permanganate
With potassium permanganate In water at 20℃;
pyrazine-2,3-dicarbonitrile
13481-25-9

pyrazine-2,3-dicarbonitrile

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride
2,5-pyrazinedicarboxylic acid
122-05-4

2,5-pyrazinedicarboxylic acid

A

1,4-pyrazine
290-37-9

1,4-pyrazine

B

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

C

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

Conditions
ConditionsYield
at 282℃;
2,3-dicarboxypyrazine
89-01-0

2,3-dicarboxypyrazine

A

1,4-pyrazine
290-37-9

1,4-pyrazine

B

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
Destillation im Vakuum;
bei der Destillation im Vakuum;
diethyl pyrazine-2,5-dicarboxylate
103150-78-3

diethyl pyrazine-2,5-dicarboxylate

A

1,4-pyrazine
290-37-9

1,4-pyrazine

B

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
rasche Destillation;
ethyl 2-pyrazinecarboxylate
6924-68-1

ethyl 2-pyrazinecarboxylate

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
With alkaline H2O In dimethyl sulfoxide at 30℃; Rate constant; other solvent (EtOH); variation of water concentrations;
2-Methylpyrazine
109-08-0

2-Methylpyrazine

aqueous permanganate solution

aqueous permanganate solution

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

monopotassium-salt of/the/ pyrazine-2,3-dicarboxylic acid

monopotassium-salt of/the/ pyrazine-2,3-dicarboxylic acid

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
With diethylene glycol
N-benzenesulfonyl-N'-pyrazinecarbonyl-hydrazine
34569-20-5

N-benzenesulfonyl-N'-pyrazinecarbonyl-hydrazine

ethylene glycol
107-21-1

ethylene glycol

Na2CO3

Na2CO3

A

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

B

pyrazinamide
98-96-4

pyrazinamide

C

N,N'-bis-(pyrazine-2-carbonyl)-hydrazine
54571-25-4

N,N'-bis-(pyrazine-2-carbonyl)-hydrazine

D

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
ConditionsYield
at 160℃;
2-ethylpiperazine
13961-37-0

2-ethylpiperazine

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2O; copper oxide-chromium oxide catalyst / 360 °C
2: KMnO4
View Scheme
2-Methylpyrazine
109-08-0

2-Methylpyrazine

A

2-methylpyrazine 4-oxide
25594-37-0

2-methylpyrazine 4-oxide

B

2-methylpyrazine 1-oxide
31396-35-7

2-methylpyrazine 1-oxide

C

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

D

pyrazinecarboxaldehyde
5780-66-5

pyrazinecarboxaldehyde

E

pyrazine-2-carboxylic acid-4-oxide
874-54-4

pyrazine-2-carboxylic acid-4-oxide

F

pyrazine-2-carboxylic acid-1-oxide
32046-09-6

pyrazine-2-carboxylic acid-1-oxide

Conditions
ConditionsYield
With acetyl peroxyborate In water at 94.84℃; for 5h;A n/a
B n/a
C 56.3 mol %
D 4.5 mol %
E n/a
F n/a
With acetyl peroxyborate In water at 94.84℃; for 5h;A n/a
B n/a
C 28.5 mol %
D 41.2 mol %
E n/a
F n/a
2-Methylpyrazine
109-08-0

2-Methylpyrazine

A

2-methylpyrazine 4-oxide
25594-37-0

2-methylpyrazine 4-oxide

B

2-methylpyrazine 1-oxide
31396-35-7

2-methylpyrazine 1-oxide

C

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

D

pyrazine-2-carboxylic acid-4-oxide
874-54-4

pyrazine-2-carboxylic acid-4-oxide

E

pyrazine-2-carboxylic acid-1-oxide
32046-09-6

pyrazine-2-carboxylic acid-1-oxide

Conditions
ConditionsYield
With peroxyacetic acid In water; acetic acid at 94.84℃; for 5h;A n/a
B n/a
C 19.2 mol %
D n/a
E n/a
pyrazinamide
98-96-4

pyrazinamide

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
With recombinant Acinetobacter baumanii pyrazinamidase/nicotinamidase; water at 30℃; Kinetics; Enzymatic reaction;
With potassium permanganate; sulfuric acid Kinetics; Mechanism; Thermodynamic data; Concentration;
With water In aq. phosphate buffer at 30℃; for 3h; pH=7; Time; Enzymatic reaction;
Alkaline conditions;
potassium pyrazinemonocarboxylate

potassium pyrazinemonocarboxylate

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In water pH=2;
2-pyrazine carbonitrile
19847-12-2

2-pyrazine carbonitrile

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide for 6h; Reflux;

98-97-5Relevant articles and documents

Specificity and mechanism of acinetobacter baumanii nicotinamidase: Implications for activation of the front-line tuberculosis drug pyrazinamide

Fyfe, Paul K.,Rao, Vincenzo A.,Zemla, Aleksandra,Cameron, Scott,Hunter, William N.

, p. 9176 - 9179 (2009)

TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a

Synthesis and spectroscopic study of three new oxadiazole derivatives with detailed computational evaluation of their reactivity and pharmaceutical potential

Mary, Y. Sheena,Miniyar, Pankaj B.,Mary, Y. Shyma,Resmi,Panicker, C. Yohannan,Armakovi?, Stevan,Armakovi?, Sanja J.,Thomas, Renjith,Sureshkumar

, p. 469 - 480 (2018)

Local reactivity properties and potential for application in new pharmaceutical compounds have been addressed for the three newly synthetized oxadiazole derivatives (2-(5-(2-nitrophenyl)-1,3,4-oxadiazol-2-yl)pyrazine (ORTHONITRO), 2-(5-(3-nitrophenyl)-1,3,4-oxadiazol-2-yl)pyrazine (METANITRO) and 2-(5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)pyrazine (PARANITRO), by application of computational molecular modeling. Within the framework of density functional theory (DFT) this study encompassed calculations of molecular electrostatic potential (MEP), average local ionization energies (ALIE) and bond dissociation energies for hydrogen abstraction (H-BDE). MD simulations have been used in order to assess the influence of water and to identify the atoms of these molecules with preference towards the interaction with water molecules. Molecular docking procedure has been applied in order to check the binding activity of these derivatives against the Glucan endo-1.6-beta-glucosidase inhibitor, Acrocylindropepsin inhibitor and Chymosin inhibitor proteins. The pharmaceutical potential of these derivatives has been assessed by the calculations of the well-established drug likeness parameters. A strong out-of-plane CH mode of the phenyl rings are observed at 769 cm?1 for ORTHONITRO, 768 cm?1 for METANITRO and at 848 cm?1 for PARANITRO in the IR spectrum as expected for substituted benzenes. The VCD signals, corresponding to C[dbnd]N and NO2 modes of the title compounds are good markers for assigning of absolute configuration. In the title compounds, in ORTHONITRO, the oxadiazole ring is tilted from the phenyl and pyrazine ring while for METANITRO and PARANITRO, there is a planar orientation. The first hyperpolariazabilities of ORTHONITRO, METANITRO and PARANITRO are respectively, 34.83, 54.50 and 174.05 times that of urea. For all the compounds, HOMO is delocalized over the pyrazine and oxadiazole rings, while LUMO is delocalized over whole molecule, except pyrazine ring of ORTHONITRO, over phenyl ring and NO2 group of METANITRO and in the entire molecule of PARANITRO. The title compounds are docked with the proteins, Glucan endo-1.6-beta-glucosidase inhibitor, Acrocylindropepsin inhibitor and Chymosin inhibitor and METANITRO exhibits more inhibitory activity against the receptors than the other ligands. The results obtained from anti-TB activity are more promising as the compounds were found to be more potent than reference standard, ORTHONITRO (MIC = 1.6 μg/ml), METANITRO (MIC = 0.8 μg/ml), PARANITRO (MIC = 1.6 μg/ml), streptomycin (MIC = 6.2 μg/ml) and pyrazinamide (MIC = 3.1 μg/ml).

Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies

Abdel-Aziz, Marwa M.,Abdel-Ghany, Yasser S.,El-Hawash, Soad A.,Elzahhar, Perihan A.,Hassan, Nayera W.,Ismail, Azza,Nassra, Rasha,Saudi, Manal N.,Sriram, Dharmarajan

, (2020/02/06)

TB continues to be a leading health threat despite the availability of powerful anti-TB drugs. We report herein the design and synthesis of various hybrid molecules comprising pyrazine scaffold and various formerly identified anti-mycobacterial moieties. Thirty-one compounds were screened in vitro for their activity against Mycobacterium tuberculosis H37Rv strain using MABA assay. The results revealed that six compounds (8a, 8b, 8c, 8d, 14b and 18) displayed significant activity against Mtb with MIC values ≤6.25 μg/ml versus 6.25 μg/ml for pyrazinamide. The most active compounds were then assessed for their in vitro cytotoxicity against PBMC normal cell line using MTT assay and showed SI > 200. Several in silico studies have been carried out for target fishing of the novel compounds such as shape-based similarity, pharmacophore mapping and inverse docking. Based on this multi-step target fishing study, we suggest that pantothenate synthetase could be the possible target responsible for the action of these compounds. The most active compounds were then successfully docked into the active site of pantothenate synthetase enzyme with favorable binding interactions. In addition, in silico prediction of physicochemical, ADMET and drug-like properties were also determined indicating that compounds 8b, 8c and 8d are promising candidates for the development of new anti-TB agents with enhanced activity and better safety profile.

Carboxylic acid complex and synthesis method thereof

-

Paragraph 0029; 0030; 0039; 0040; 0049; 0050, (2017/07/20)

The invention discloses a carboxylic acid complex, belonging to the technical field of chemical synthesis. The carboxylic acid complex is composed of 30-50ml of anhydrous ethanol, 0.2-0.5 mol/L 2-methyl pyrazine, 1.25-1.6 mol/L potassium hydroxide solution and 5.0*10-5.0*10 mol/L catalyst. The synthesis method of the carboxylic acid complex comprises the following steps: S1: adding the 5.0*10-5.0*10 mol/L catalyst to react; S2: after the reaction finishes, carrying out vacuum filtration while the solution is hot; and S3: filtering the precipitate generated in the step S2, washing, and recrystallizing with hot water to obtain the solid carboxylic acid complex. The operating method is simple, and the carboxylic acid complex has high yield. The added catalyst converts oxygen molecules into an effective oxidizer, and thus, substitutes the expensive and polluting chemical oxidizer, thereby lowering the production cost, reducing the generation of three wastes and conforming to the energy-saving demand of clean production at present.

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