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CLOPERASTINE

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Name

CLOPERASTINE

EINECS N/A
CAS No. 3703-76-2 Density 1.12g/cm3
PSA 12.47000 LogP 4.86980
Solubility N/A Melting Point N/A
Formula C20H24 Cl N O Boiling Point 423.9°Cat760mmHg
Molecular Weight 329.87 Flash Point 210.2°C
Transport Information N/A Appearance N/A
Safety Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cl and NOx. Risk Codes N/A
Molecular Structure Molecular Structure of 3703-76-2 (CLOPERASTINE) Hazard Symbols N/A
Synonyms

Piperidine,1-[2-[(p-chloro-a-phenylbenzyl)oxy]ethyl]-(6CI,7CI,8CI); (?à)-Cloperastine;1-[2-[(p-Chloro-a-phenylbenzyl)oxy]ethyl]piperidine;Cloperastine; p-Chlorobenzhydryl 2-(1-piperidyl)ethyl ether

Article Data 2

CLOPERASTINE Synthetic route

110-89-4

piperidine

5321-46-0, 132301-88-3

(4-chlorophenyl)phenylmethyl 2-chloroethyl ether

3703-76-2

Cloperastine

Conditions
ConditionsYield
With sodium carbonate at 95℃; for 14h;80.7%
119-56-2

(4-chlorophenyl)phenylmethanol

3703-76-2

Cloperastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / toluene / 5 h / Reflux
2: sodium carbonate / 14 h / 95 °C
View Scheme
3703-76-2

Cloperastine

84627-04-3

2-<(2'-hydroxy-5'-biphenylyl)carbonyl>benzoic acid

levocloperastine fendizoate

Conditions
ConditionsYield
In water; acetone for 2h; Solvent; Reflux;96.2%
745783-97-5

triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

3703-76-2

Cloperastine

1-(2-(phenyl(4-(triethylsilyl)phenyl)methoxy)ethyl)piperidine

Conditions
ConditionsYield
With 3,4,7,8-Tetramethyl-o-phenanthrolin; ferrous iodide; sodium t-butanolate In tetrahydrofuran at 120℃; for 12h; Schlenk technique; Glovebox; Inert atmosphere;88%
3703-76-2

Cloperastine

2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-methylbutanoic acid chloromethyl ester

1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-1-[[2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-methyl-1-oxobutoxy]methyl]piperidinium chloride

Conditions
ConditionsYield
In dichloromethane at 70℃; for 1h;85%
3703-76-2

Cloperastine

C20H13(2)H11ClNO*ClH

Conditions
ConditionsYield
Stage #1: Cloperastine With water-d2; lithium carbonate; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; Irradiation;
Stage #2: With hydrogenchloride In 1-methyl-pyrrolidin-2-one
78%
3703-76-2

Cloperastine

3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,2-dimethylpropanoic acid iodomethyl ester

1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-1-[[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,2-dimethyl-1-oxopropoxy]methyl]piperidinium iodide

Conditions
ConditionsYield
In dichloromethane at 70℃; for 3h;78%
3703-76-2

Cloperastine

sodium trimethylsilyldimethylsilanolate

1-(2-(phenyl(4-trimethylsilylphenyl)methoxy)ethyl)piperidine

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0); Dimethyl(phenyl)phosphine In toluene at 70℃; for 18h; Schlenk technique; Sealed tube;59%
3703-76-2

Cloperastine

levocloperastine

Conditions
ConditionsYield
With di-p-anisoyl-L-tartaric acid In ethanol at 60℃; for 2h;
3703-76-2

Cloperastine

C20H13(3)H11ClNO

Conditions
ConditionsYield
With tritium oxide In 1-methyl-pyrrolidin-2-one at 20℃; Irradiation;

CLOPERASTINE Chemical Properties

Product Name: Cloperastine (CAS NO.3703-76-2)


Molecular Formula: C20H24ClNO
Molecular Weight: 329.86g/mol
Mol File: 3703-76-2.mol
Einecs: 223-042-3
Boiling point: 423.9 °C at 760 mmHg
Storage Temperature:
Flash Point: 210.2 °C
Density: 1.12 g/cm3
Surface Tension: 42.1 dyne/cm
Enthalpy of Vaporization: 67.83 kJ/mol
Vapour Pressure: 2.15E-07 mmHg at 25°C
XLogP3-AA: 4.8
H-Bond Donor: 0
H-Bond Acceptor: 2

CLOPERASTINE Toxicity Data With Reference

1.    

orl-rat LD50:2325 mg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),241.
2.    

ipr-rat LD50:120 mg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),241.
3.    

orl-mus LD50:600 mg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),241.
4.    

ipr-mus LD50:96 mg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),241.

CLOPERASTINE Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cl and NOx.

CLOPERASTINE Specification

 Cloperastine ,its CAS NO. is 3703-76-2,the synonyms is 1-(2-((4-Chlorophenyl)phenylmethoxy)ethyl)-piperidin ; 1-(2-((4-Chlorophenyl)phenylmethoxy)ethyl)piperidine ; 1-(2-((p-Chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidin ; 1-(2-[(4-Chlorophenyl)(phenyl)methoxy]ethyl)piperidine ; 1-[2-[p-Chloro-phenylbenzyl)-oxy]ethy]piperidine ; 1-{2-[(p-Chloro-alpha-phenylbenzyl)oxy]ethyl}piperidine ; Piperidine, 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)- .

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