110-89-4

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

DOT Classification:  3; Label: Flammable Liquid

This product is an organic compound with the formula C₅H₁₁N. The IUPAC name of this chemical is Piperidine. It belongs to the product categories of Piperidine; Other Reagents; Chemistry; Solvents and Mixtures for Peptide Synthesis; Peptide Synthesis; Specialty Synthesis; Bases Chemical Synthesis; Organic Bases; Supported Reagents; Supported Synthesis; Synthetic Reagents. Its EINECS number is 203-813-0. With the CAS registry number 110-89-4, it is also named as Cyclopentimine. In addition, the molecular weight is 85.15. Its classification codes are: (1)Calcium Channel Blockers; (2)Cardiovascular Agents; (3)Membrane Transport Modulators; (4)Mutation data; (5)Reproductive Effect; (6)Skin / Eye Irritant. It should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides, heat, fire and light. It is commonly used as the intermediates for the synthesis of pharmaceuticals, raw materials of rubber accelerator and the curing agent of epoxy resins.

Physical properties of Piperidine are: (1)ACD/LogP: 0.61; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 1; (8)#H bond donors: 1; (9)#Freely Rotating Bonds: 0; (10)Polar Surface Area: 12.03 Å²; (11)Index of Refraction: 1.429; (12)Molar Refractivity: 26.407 cm³; (13)Molar Volume: 102.488 cm³; (14)Polarizability: 10.468×10^-24cm³; (15)Surface Tension: 26.728 dyne/cm; (16)Density: 0.831 g/cm³; (17)Flash Point: 4.444 °C; (18)Enthalpy of Vaporization: 34.531 kJ/mol; (19)Boiling Point: 106.399 °C at 760 mmHg; (20)Vapour Pressure: 28.325 mmHg at 25°C.

Preparation of Piperidine: this chemical can be produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst.

C₅H₅N + 3 H₂ → C₅H₁₀NH

Uses of Piperidine: it can be used to produce 1-(6-amino-pyridin-2-ylamino)-3-piperidin-1-yl-propan-2-ol by heating. It will need solvent methanol with the reaction time of 24 hours. The yield is about 35%.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful by inhalation and in contact with skin. It is highly flammable, so you should keep it away from sources of ignition - No smoking. It is toxic by inhalation and in contact with skin and can cause burns. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. You must take off immediately all contaminated clothing. When using it, you need wear suitable protective clothing and should avoid contact with eyes. In case of accident or if you feel unwell, you need seek medical advice immediately (show the label where possible). It should be avoided exposure that you should obtain special instructions before use.

You can still convert the following datas into molecular structure:
(1)SMILES: C1CCNCC1
(2)Std. InChI: InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
(3)Std. InChIKey: NQRYJNQNLNOLGT-UHFFFAOYSA-N

The toxicity data is as follows: