CGRP Receptor Antagonists
CGRP (calcitonin gene-related peptide) receptor antagonists are pharmaceutical agents designed to block the action of CGRP receptors, which play a crucial role in the transmission of pain signals. CGRP is a neuropeptide involved in vasodilation and inflammation, and its receptors are found throughout the central and peripheral nervous systems. By inhibiting CGRP receptor activity, these antagonists aim to reduce the frequency and severity of migraines and other headache disorders, where CGRP levels are often elevated.
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