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Clinofibrate
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Name

Clinofibrate

 EINECS 1312995-182-4
CAS No. 30299-08-2 Density 1.163 g/cm3
PSA 93.06000 LogP 6.20100
Solubility N/A Melting Point 143-145°C
Formula C28H36O6 Boiling Point 619.2 °C at 760 mmHg
Molecular Weight 468.59 Flash Point 200.3 °C
Transport Information N/A Appearance White crystalline powder
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 30299-08-2 (Clinofibrate) Hazard Symbols N/A
Synonyms

1,1-Bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane;Butanoic acid,2,2'-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-;Lipoclin;S 8527;

Article Data 3

Clinofibrate Chemical Properties

IUPAC: 2-[4-[1-[4-(1-Hydroxy-2-methyl-1-oxobutan-2-yl)oxyphenyl]cyclohexyl]phenoxy]-2-methylbutanoic acid 
Molecular Formula: C28H36O6 
Molecular Weight: 468.58 g/mol
Molecule structure of Clinofibrate (CAS NO.30299-08-2):


Density: 1.163 g/cm3 
Flash Point: 198.1 °C 
Enthalpy of Vaporization: 95.77 kJ/mol 
Boiling Point: 613.8 °C at 760 mmHg 
Vapour Pressure: 6.38E-16 mmHg at 25 °C 
Index of Refraction: 1.558
Molar Refractivity: 129.94 cm3
Molar Volume: 402.6 cm3
Surface Tension: 47.4 dyne/cm 
XLogP3-AA: 7.5
H-Bond Donor: 2
H-Bond Acceptor: 6
Rotatable Bond Count: 10
Exact Mass: 468.251189
MonoIsotopic Mass: 468.251189
Topological Polar Surface Area: 93.1
Heavy Atom Count: 34 
Canonical SMILES: CCC(C)(C(=O)O)OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(C=C3)OC(C)(CC)C(=O)O
InChI: InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)
InChIKey: BMOVQUBVGICXQN-UHFFFAOYSA-N
Product Categories: API

Clinofibrate Uses

 Clinofibrate (CAS NO.30299-08-2) is lipid-lowering drugs, not only inhibit the occurrence of hyperlipidemia, but also significantly reduce levels of plasma endothelin. 

Clinofibrate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 230mg/kg (230mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1553, 1981.
mouse LD50 intravenous 150mg/kg (150mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981.
mouse LD50 oral 1600mg/kg (1600mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.
mouse LD50 subcutaneous 350mg/kg (350mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.
rat LD50 intraperitoneal 205mg/kg (205mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981.
rat LD50 intravenous > 150mg/kg (150mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.
rat LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.
rat LD50 subcutaneous 1930mg/kg (1930mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.

Clinofibrate Specification

 Clinofibrate (CAS NO.30299-08-2) is also named as 2,2'-(4,4'-Cyclohexylidenediphenoxy)-2,2'-dimethyldibutyric acid ; 2,2'-(Cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methylbutanoic acid) ; 2,2'-(Cyclohexylidenebis(p-phenyleneoxy))bis(2-
methylbutyric acid) ; 2,2'-Cyclohexane-1,1-diylbis(p-phenyleneoxy)bis(2-methylbutyric acid) ; 2,2'-Dimethyl-2,2'-(4,4'-
cyclohexylidendiphenoxy)dibuttersaeure ; BRN 2230067 ; Clinofibrato ; Clinofibrato [INN-Spanish] ; Clinofibratum ; Clinofibratum [INN-Latin] ; Lipoclin ; S 8527 ; UNII-0374EZJ8CU . Clinofibrate (CAS NO.30299-08-2) is a fibrate.

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