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Name	D-alpha-Cyclohexylglycine	EINECS	N/A
CAS No.	14328-52-0	Density	1.12 g/cm³
PSA	63.32000	LogP	1.67890
Solubility	soluble in water	Melting Point	256 °C
Formula	C₈H₁₅NO₂	Boiling Point	292.8 °C at 760 mmHg
Molecular Weight	157.213	Flash Point	130.9 °C
Transport Information	N/A	Appearance	white powder
Safety	37/39-26	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	Cyclohexaneaceticacid, a-amino-, (R)-;Cyclohexaneaceticacid, a-amino-, D- (8CI);(R)-2-Amino-2-cyclohexylacetic acid;D-Cyclohexylglycine;D-a-Aminocyclohexaneacetic acid;	Article Data	9

D-alpha-Cyclohexylglycine Synthetic route

: 875-74-1
(R)-phenylglycine

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen In water; isopropyl alcohol at 50 - 60℃; for 6 - 8h;	95.8%
With hydrogen; platinum(IV) oxide In acetic acid Ambient temperature;	91%
With hydrogenchloride; hydrogen; rhodium under 38000 Torr; for 240h;	79%
With hydrogenchloride; platinum at 70℃; Hydrogenation;
With hydrogenchloride; hydrogen; platinum(IV) oxide In ethanol

: 5963-46-2, 59759-91-0, 145416-94-0
(R)-benzoylamino-cyclohexyl-acetic acid

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 2935-35-5
(S)-2-phenylglycine

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
(i) aq. HCl, (ii) (hydrogenation); Multistep reaction;

: 14429-43-7
(R)-(acetylamino)-(cyclohexyl)acetic acid

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
With hydrogen bromide Heating;

: 63546-36-1
(R)-phenylglycine, N-salicylidene derivative

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide

: 54750-25-3
ristomycinic acid

A: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

B: 76249-99-5
(S)-Amino-(3,5-dihydroxy-4-methyl-phenyl)-acetic acid

Conditions

Conditions	Yield
With hydrogen

: 5664-29-9
2-cyclohexylglycine

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: quinine 3: aqueous HCl View Scheme
Multi-step reaction with 2 steps 1: acetic acid / (enzymatic racemate resolution) 2: aq. HBr / Heating View Scheme

: 59759-91-0
N-benzoyl-α-cyclohexylglycine

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: quinine 2: aqueous HCl View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 929003-25-8
(R)-2-bromo-2-cyclohexylacetic acid

Conditions

Conditions	Yield
With hydrogen bromide; sodium nitrite In water at 0℃; for 2.5h;	92%

: 24424-99-5
di-tert-butyl dicarbonate

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 70491-05-3
(2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid

Conditions

Conditions	Yield
Stage #1: di-tert-butyl dicarbonate; (R)-2-amino-2-cyclohexyl acetic acid With sodium carbonate In water; acetone at 20℃; for 16h; Stage #2: With potassium hydrogensulfate In water pH=1;	89%
With tetramethyl ammoniumhydroxide	73%

D-alpha-Cyclohexylglycine Chemical Properties

ProductName: D-Cyclohexylglycine
CAS No.: 14328-52-0
Molecular Formula: C₈H₁₅NO₂
Molecular Weight: 157.21 g/mol
Melting Point: 256 °C
Polar Surface Area: 29.54 Å²
Index of Refraction: 1.51
Molar Refractivity: 42 cm³
Molar Volume: 140.3 cm³
Surface Tension: 47.6 dyne/cm
Enthalpy of Vaporization: 58.57 kJ/mol
Vapour Pressure: 0.000441 mmHg at 25°C
Density: 1.12 g/cm³
Flash Point: 130.9 °C
Boiling Point: 292.8 °C at 760 mmHg
Following is the structure:

The chemical synonymous of D-Cyclohexylglycine (CAS NO.14328-52-0) are (R)-Cyclohexylglycine ; (R)-Amino-cyclohexyl-acetic acid ; R)-(+)-Alpha-aminocyclohexylacetic acid ; R)-Alpha-aminocyclohexylacetic acid ; D-Cyclohexylglycine ; D-Chg;d-2-cyclohexyl-glycine ; D-2-Cyclohexylglycine trifluoroacetate
Product Categories is mainly refer to Peptide.

D-alpha-Cyclohexylglycine Safety Profile

Hazard Codes:
    Xi: Irritant
Risk Statements about D-Cyclohexylglycine (CAS NO.14328-52-0):
    R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements:
    S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    S37/39 Wear suitable gloves and eye/face protection.

D-alpha-Cyclohexylglycine Specification

1. Storage: Store in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4°C/39°F.)
2. Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
3. Personal Protection: Eyes: Wear chemical splash goggles.Skin: Wear appropriate protective gloves to prevent skin exposure.Clothing: Wear appropriate protective clothing to prevent skin exposure.Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
4. Fire Fighting: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.

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