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| CAS No.: | 875-74-1 |
|---|---|
| Name: | D-2-Phenylglycine |
| Molecular Structure: | |
|
|
|
| Formula: | C8H9NO2 |
| Molecular Weight: | 151.165 |
| Synonyms: | Benzeneaceticacid, a-amino-, (R)-;(R)-a-Phenylglycine;D-(-)-2-Phenylglycine;D-(-)-Aminophenylacetic acid;D-(-)-Phenylglycine;D-(-)-a-Aminophenylacetic acid;D-(-)-a-Phenylglycine;D-2-Phenylglycine;D-C-Phenylglycine;D-Phenylglycine;D-a-Aminophenylacetic acid;Glycine,2-phenyl-, D- (8CI);(-)-(R)-Phenylglycine;(-)-Phenylglycine;(2R)-Amino-2-phenylethanoic acid;(R)-(-)-2-Phenylglycine;(R)-2-Amino-2-(phenyl)ethanoic acid;(R)-2-Amino-2-phenylacetic acid;(R)-2-Phenylglycine;(R)-Phenylglycine; |
| EINECS: | 212-876-3 |
| Density: | 1.246 g/cm3 |
| Melting Point: | 302 °C (dec.)(lit.) |
| Boiling Point: | 288.7 °C at 760 mmHg |
| Flash Point: | 128.4 °C |
| Solubility: | 0.3 g/100mL in water |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
T
|
| Risk Codes: | 23/24/25-36/37/38 |
| Safety: | 22-24/25-45-36/37/39-26 |
| PSA: | 63.32000 |
| LogP: | 1.47130 |

(R)-2-azido-2-phenylacetic acid


(R)-phenylglycine

| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In water; acetic acid under 760 Torr; for 3h; | 97% |

| Conditions | Yield |
|---|---|
| With nitrilase AY487533 In aq. acetate buffer at 20℃; for 1h; pH=8; Enzymatic reaction; enantioselective reaction; | 96.5% |


(R)-phenylglycine

| Conditions | Yield |
|---|---|
| With hydrogenchloride; water In water at 110℃; for 3h; optical yield given as %ee; | 94% |

Boc-D-Phg-OH


(R)-phenylglycine

| Conditions | Yield |
|---|---|
| With trifluoroacetic acid for 0.333333h; | 89% |
| With hydrogenchloride; Dowex 50*8 1.) THF, room temperature, 2 h.; Yield given. Multistep reaction; |

6-Aminopenicillanic Acid


(R)-phenylglycine amide

A

(R)-phenylglycine

B

ampicillin

| Conditions | Yield |
|---|---|
| With A. faecalis; immobilised penicillin acylase (EC 3.5.1.11) In water; acetonitrile at 0℃; Product distribution; Kinetics; Further Variations:; Solvents; reusing run; Enzymatic reaction; | A n/a B 86% |


N-(2,4,6-trimethyl-benzenesulfonyl)-D-phenylglycine


(R)-phenylglycine

| Conditions | Yield |
|---|---|
| With sodium naphthalenide In 1,2-dimethoxyethane at -40℃; for 0.5h; | 78% |

(R)-(furan-2-yl)(phenyl)methanamine


(R)-phenylglycine

| Conditions | Yield |
|---|---|
| With ozone In methanol at -78℃; for 0.25h; | 78% |

N-acetyl-α-phenylglycine


(R)-phenylglycine

| Conditions | Yield |
|---|---|
| With water at 30℃; for 26h; D-aminoacylase from Streptomyces tuirus IFO 13418; | 74% |

MANDELIC ACID


(R)-phenylglycine

| Conditions | Yield |
|---|---|
| With D-glucose; ammonia; ammonium chloride In aq. phosphate buffer at 30℃; for 24h; pH=8; Catalytic behavior; Reagent/catalyst; Microbiological reaction; Green chemistry; Enzymatic reaction; enantioselective reaction; | 71% |

[(1R)-2-(benzyloxy)-2-oxo-1-phenylethyl]ammonium 4-methyl-1-benzensulfonate


(R)-phenylglycine

| Conditions | Yield |
|---|---|
| With hydrogenchloride Heating; | 69% |
IUPAC Name: (2R)-2-azaniumyl-2-phenylacetate
Empirical Formula: C8H9NO2
Molecular Weight: 151.1626g/mol
EINECS: 212-876-3
Structure of D-2-Phenylglycine (CAS NO.875-74-1):

Index of Refraction: 1.589
Molar Refractivity: 40.9 cm3
Molar Volume: 121.3 cm3
Polarizability: 16.21×10-24cm3
Surface Tension: 57 dyne/cm
Density: 1.246 g/cm3
Flash Point: 128.4 °C
Enthalpy of Vaporization: 55.75 kJ/mol
Melting Point: 302 °C (dec.)(lit.)
Boiling Point: 288.7 °C at 760 mmHg
Vapour Pressure: 0.00107 mmHg at 25°C
Water Solubility: 0.3g/100mL
Product Categories: GLYCINESCAFFOLD;Pharmaceutical Intermediates;Amino ACIDS SERIES;Phenylglycine [Phg];Unusual Amino Acids;Amino Acids
Canonical SMILES: C1=CC=C(C=C1)C(C(=O)[O-])[NH3+]
Isomeric SMILES: C1=CC=C(C=C1)[C@H](C(=O)[O-])[NH3+]
InChI: InChI=1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11)/t7-/m1/s1
InChIKey: ZGUNAGUHMKGQNY-SSDOTTSWSA-N
Hazard Codes:
T
Risk Statements: 23/24/25-36/37/38
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-45-36/37/39-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
HS Code: 29224995
D-2-Phenylglycine , its cas register number is 875-74-1. It also can be called Benzeneacetic acid, alpha-amino-, (alphaR)- ;
D-(-)-alpha-Phenylglycine . D-2-Phenylglycine (CAS NO.875-74-1) is a white crystalline powder.