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| CAS No.: | 50-47-5 |
|---|---|
| Name: | DESIPRAMINE |
| Molecular Structure: | |
|
|
|
| Formula: | C18H22 N2 |
| Molecular Weight: | 266.386 |
| Synonyms: | 5H-Dibenz[b,f]azepine,10,11-dihydro-5-[3-(methylamino)propyl]- (6CI,8CI); 10,11-Dihydro-5-[3-(methylamino)propyl]-5-H-dibenz[b,f]azepine;DMI; DMI (pharmaceutical); Demethylimipramine; Desimipramine; Desipramin;Desipramine; Desmethylimipramine; Imipramine, demethyl-;Methylaminopropyliminodibenzyl; Monodemethylimipramine; N-Desmethylimipramine;Norimipramine |
| EINECS: | 200-040-0 |
| Density: | 1.047 g/cm3 |
| Melting Point: | 212°C |
| Boiling Point: | 407.4 °C at 760 mmHg |
| Flash Point: | 160.5 °C |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 20/21/22 |
| Safety: | 36 |
| PSA: | 15.27000 |
| LogP: | 3.98870 |
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| Conditions | Yield |
|---|---|
| Stage #1: formaldehyd In methanol at 20℃; for 0.25h; Stage #2: didesmethylimipramine With methanol; sodium tetrahydroborate at 80℃; for 0.666667h; Microwave irradiation; | 44% |
- 65100-48-3
10,11-dihydro-N-methyl-N-(methyl-d3)-5H-dibenz(b,f)azepine-5-propanamine
A
- 50-47-5
desipramine
B
- 65100-49-4
5-[3-(N-trideuteromethylamino)propyl]iminodibenzyl
| Conditions | Yield |
|---|---|
| With liver microsomes of a rat Product distribution; other reagent (anodic oxidation); |
| Conditions | Yield |
|---|---|
| With D-glucose; corn steep liquor; S. aureus; peptone; yeast extract In water at 37℃; Product distribution; other reagents; | |
| With oxygen; palladium on activated charcoal In methanol for 24h; Ambient temperature; | |
| With pooled human liver microsomes; Tris buffer; NADPH; magnesium chloride at 37℃; pH=7.4; Enzyme kinetics; | |
| With human hepatic CYP1A2; human hepatic CYP2C9; human hepatic CYP3A4 Enzymatic reaction; | |
| Multi-step reaction with 2 steps 1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 1 h / Reflux 2: 2 h / Reflux View Scheme |
- 113-52-0
Imipramine hydrochloride
A
- 50-47-5
desipramine
B
- 494-19-9
9,10-dihydrodibenzazepine
C
- 796-28-1
10-Hydroxyimipramine
| Conditions | Yield |
|---|---|
| In water Ambient temperature; M. griseo-cyanus (ATCC 1207a); further microbial agents; | A 10 mg B n/a C n/a |
- 113-52-0
Imipramine hydrochloride
A
- 50-47-5
desipramine
B
- 494-19-9
9,10-dihydrodibenzazepine
C
- 796-28-1
10-Hydroxyimipramine
D
- 303-70-8
2-hydroxyimipramine
| Conditions | Yield |
|---|---|
| In water for 480h; Ambient temperature; C. blakesleeana (ATCC 8688a); further microbial agents; Further byproducts given; | A n/a B n/a C 30 mg D 88 mg |
- 927207-60-1
2-((2Ξ,4S)-3,4r-dimethyl-5c-phenyl-oxazolidin-2-yl)-phenol
- 50-47-5
desipramine
| Conditions | Yield |
|---|---|
| With buffer solution; potassium chloride In water at 37℃; Rate constant; other reagents; |
- 19009-26-8
[3-(10,11-Dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-ethyl-methyl-amine
A
- 50-47-5
desipramine
B
- 2095-96-7
10,11-dihydro-N-ethyl-5H-dibenzazepine-5-propanamine
| Conditions | Yield |
|---|---|
| With liver microsomes of a rat Product distribution; other reagent (anodic oxidation); |
- 81256-33-9
[3-(10,11-Dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-isopropyl-methyl-amine
A
- 50-47-5
desipramine
B
- 2292-76-4
10,11-dihydro-N-isopropyl-5H-dibenzazepine-5-propanamine
| Conditions | Yield |
|---|---|
| With liver microsomes of a rat Product distribution; other reagent (anodic oxidation); |
- 81256-34-0
Butyl-[3-(10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-methyl-amine
A
- 50-47-5
desipramine
B
- 2064-08-6
10,11-dihydro-N-butyl-5H-dibenzazepine-5-propanamine
| Conditions | Yield |
|---|---|
| With liver microsomes of a rat Product distribution; other reagent (anodic oxidation); |
- 50-47-5
desipramine
| Conditions | Yield |
|---|---|
| With buffer solution; potassium chloride In water at 37℃; Rate constant; other reagents; |
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Chemistry
IUPAC Name: 3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
The MF of Desipramine (CAS NO.50-47-5) is C18H22N2.
The MW of Desipramine (CAS NO.50-47-5) is 266.38.
Synonyms of Desipramine (CAS NO.50-47-5): (3-(10H,11H-Dibenzo[b,f]azepin-5-yl)propyl)methylamine ; 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine ; 5-(g-Methylaminopropyl)iminodibenzyl ; 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-
Index of Refraction: 1.576
EINECS: 200-040-0
Density: 1.047 g/ml
Flash Point: 160.5 °C
Boiling Point: 407.4 °C
Form: powder
Color: white
Uses
Desipramine (CAS NO.50-47-5) is used in chemical reagents, organic intermediates, fine chemicals, pharmaceutical research and development.
Toxicity Data With Reference
| 1. | dnd-esc 20 µmol/L | MUREAV Mutation Research. 89 (1981),95. | ||
| 2. | cyt-oin-unr 10 g/L | JCLBA3 Journal of Cell Biology. 47 (1970),182a. | ||
| 3. | orl-wmn LDLo:30 mg/kg:BRN,CNS | 34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,201. | ||
| 4. | orl-chd LDLo:125 mg/kg:CNS,PUL | PSYPAG Psychopharmacologia (Berlin). 10 (1967),431. | ||
| 5. | orl-hmn LDLo:30 mg/kg:CNS,BRN,PUL | DMWOAX Deutsche Medizinische Wochenschrift. 93 (1968),117. | ||
| 6. | orl-rat LD50:375 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 19 (1969),1617. | ||
| 7. | ipr-rat LD50:48 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 20 (1970),1561. | ||
| 8. | scu-rat LD50:183 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 20 (1970),1561. | ||
| 9. | ivn-rat LD50:29 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 148 (1964),560. | ||
| 10. | orl-mus LD50:448 mg/kg | JJPAAZ Japanese Journal of Pharmacology. 21 (1971),47. | ||
Safety Profile
Human poison by ingestion. Experimental poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: degenerative brain changes, tremors, coma, and cyanosis. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. An antidepressant. Related to diazepam. When heated to decomposition it emits toxic fumes of NOx.Safety information of Desipramine (CAS NO.50-47-5):
Hazard Codes 
Xn
Risk Statements
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
Safety Statements
36 Wear suitable protective clothing
WGK Germany 3