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Cas Database

Name	Dimemorfan phosphate	EINECS	252-958-6
CAS No.	36304-84-4	Density	1.07g/cm³
PSA	90.81000	LogP	2.69250
Solubility	N/A	Melting Point	267-269°
Formula	C₁₈H₂₅N^.H₃O₄P	Boiling Point	366.9°Cat760mmHg
Molecular Weight	353.398	Flash Point	158.3°C
Transport Information	N/A	Appearance	N/A
Safety	Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Used as an antitussive agent. When heated to decomposition it emits very toxic fumes of NO_x and PO_x. See also PHOSPHATES.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	DIMEMORFAN PHOSPHATE;(9alpha,13alpha,14alpha)-3,17-dimethylmorphinan dihydrogen phosphate;Astomin;dimemorphan phosphate;Morphinan, 3,17-dimethyl-, (9α,13α,14α)-, phosphate (1:1)	Article Data	3

Dimemorfan phosphate Chemical Properties

D-3-methyl-N-methylmorphinan phosphate(36304-84-4) exists as bitter-tasting crystals. D-3-methyl-N-methylmorphinan phosphate(36304-84-4) is slightly soluble in H₂O and methanol, and it is insoluble in acetone, ethanol, ether.
Molecular Formula: C₁₈H₂₅N^.H₃O₄P.
Molecular Weight: 353.44.
Density: 1.07g/cm³.
Boiling Point: 366.9 ℃ at 760mmHg.
Flash Point: 158.3 ℃.
Molecular Structure:

Dimemorfan phosphate Uses

D-3-methyl-N-methylmorphinan phosphate(36304-84-4) is neuroprotective to inflammation-mediated neurodegenerative diseases through mechanisms of σ₁receptors. D-3-methyl-N-methylmorphinan phosphate(36304-84-4), an analogue of dextromethorphan, is used as nonopioid antitussive.

Dimemorfan phosphate Toxicity Data With Reference

1.	orl-rat LD50:690 mg/kg	MEIEDD Merck Index. 10 (1983),466.
2.	ipr-rat LD50:124 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 6 (1972),1207.
3.	scu-rat LD50:556 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),345.
4.	ivn-rat LD50:57 mg/kg	MEIEDD Merck Index. 10 (1983),466.
5.	orl-mus LD50:475 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 26 (1976),353.
6.	scu-mus LD50:223 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 26 (1976),353.
7.	ivn-mus LD50:33,900 µg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 6 (1972),1207.
8.	ivn-dog LD50:35 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 26 (1976),353.

Dimemorfan phosphate Safety Profile

Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Used as an antitussive agent. When heated to decomposition it emits very toxic fumes of NO_x and PO_x. See also PHOSPHATES.

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