Products Categories
| CAS No.: | 120014-06-4 |
|---|---|
| Name: | 2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one |
| Molecular Structure: | |
|
|
|
| Formula: | C24H29NO3 |
| Molecular Weight: | 379.499 |
| Synonyms: | 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine;Donepezil base; |
| EINECS: | 601-651-9 |
| Density: | 1.141 g/cm3 |
| Melting Point: | 207 ºC |
| Boiling Point: | 527.9 ºC at 760 mmHg |
| Flash Point: | 273.1 ºC |
| Solubility: | 2.931 mg/L in water |
| Appearance: | white or almost white crystal powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 38.77000 |
| LogP: | 4.29900 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 1219080-61-1IMIDAZOLE-2-BORONIC ACID
- 120014-06-4
donepezil
| Conditions | Yield |
|---|---|
| In methanol | 99% |
- 120014-06-4
donepezil
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water; ethyl acetate for 0.5h; pH=11.7; Reagent/catalyst; Solvent; pH-value; | 97.5% |
| With sodium hydrogencarbonate In water; toluene at 60 - 65℃; for 0.5h; Purification / work up; | |
| Stage #1: donepezil hydrochloride With sodium hydrogencarbonate In water; toluene at 60 - 65℃; for 0.75h; Stage #2: In water; isopropyl alcohol at 10 - 70℃; for 10h; Product distribution / selectivity; |
- 100-39-0
benzyl bromide
- 120014-06-4
donepezil
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide Product distribution / selectivity; | 96% |
| Conditions | Yield |
|---|---|
| With sodium carbonate In ethanol at 50 - 60℃; for 6h; | 92.3% |
| With triethylamine In dichloromethane for 4h; Heating / reflux; | |
| Stage #1: benzyl bromide; debenzyldonepezil With tetrabutylammomium bromide; potassium carbonate In dichloromethane; water at 20℃; Stage #2: With hydrogenchloride In methanol |
- 259170-03-1
2-(3,4-dimethoxybenzyl)-3-(N-benzyl-4-piperidine)propionic acid
- 120014-06-4
donepezil
| Conditions | Yield |
|---|---|
| With trifluorormethanesulfonic acid; trifluoroacetic anhydride In dichloromethane at 24 - 28℃; Inert atmosphere; chemoselective reaction; | 90% |
- 120014-06-4
donepezil
| Conditions | Yield |
|---|---|
| With sodium dithionite; tetrabutylammomium bromide; sodium hydrogencarbonate In water; ethyl acetate | 88% |
| With sodium dithionite; tetrabutylammomium bromide; water; sodium hydrogencarbonate In ethyl acetate at 65℃; for 0.5h; Solvent; Temperature; Time; | 88% |
| With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr; for 12h; | 78% |
| With hydrogen; palladium carbon In methanol at 20℃; under 760.051 Torr; for 2h; | 31 g |
| With hydrogen In tetrahydrofuran; water; isopropyl alcohol at 25℃; under 760.051 Torr; for 20h; Catalytic behavior; Flow reactor; chemoselective reaction; | 95 %Spectr. |
| Conditions | Yield |
|---|---|
| With aluminum oxide; Pt/Al2O3 In tetrahydrofuran; ethanol; water; isopropyl alcohol at 45 - 55℃; for 7h; Temperature; Solvent; Reagent/catalyst; Aldol Condensation; | 88% |
| Multi-step reaction with 2 steps 1: sodium methylate / tetrahydrofuran 2: palladium 10% on activated carbon; hydrogenchloride / ethanol; water View Scheme |
- 120012-04-6
1-benzyl-4-[(5,6-dimethoxy-1-indanol)-2-yl]methylpiperidine
- 120014-06-4
donepezil
| Conditions | Yield |
|---|---|
| With tert.-butylhydroperoxide; tetrabutylammomium bromide In decane; benzene at 40℃; for 24h; Sealed tube; chemoselective reaction; | 85% |
| Conditions | Yield |
|---|---|
| With bis(μ-chloro)-bis[1,3-di(2-pyridyl)-4,6-dimethylbenzene-N,C(2'),N-iridium chloride]; caesium carbonate In tert-Amyl alcohol for 12h; Reflux; | 85% |
| With [Ir(dpyx-N,C,N)Cl(i-Cl)]2; caesium carbonate In tert-Amyl alcohol at 130℃; for 2h; Reagent/catalyst; | 85% |
| With potassium phosphate tribasic trihydrate; C39H32Cl2N5PRu In tert-Amyl alcohol at 120℃; for 4h; Inert atmosphere; Schlenk technique; | 83% |
- 120014-06-4
donepezil
| Conditions | Yield |
|---|---|
| With potassium hydroxide In ethanol; water for 1h; Heating / reflux; | 80% |
| With potassium hydroxide In ethanol; water for 1h; Heating / reflux; | 80% |
What can I do for you?
Get Best Price
Chemistry
Molecular Structure:
.png)
Molecular Formula: C24H29NO3
Molecular Weight: 379.492
IUPAC Name: 2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Synonyms of Donepezil (CAS NO.120014-06-4): Donepezil [INN:BAN] ; UNII-8SSC91326P ; 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-
CAS NO: 120014-06-4
Classification Code: Central Nervous System Agents ; Cholinergic Agents ; Cholinesterase Inhibitors ; Enzyme Inhibitors ; Neurotransmitter Agents ; Nootropic Agents
Melting point: 207°C
Index of Refraction: 1.578
Molar Refractivity: 110.39 cm3
Molar Volume: 332.4 cm3
Surface Tension: 45.2 dyne/cm
Density: 1.141 g/cm3
Flash Point: 273.1 °C
Enthalpy of Vaporization: 80.26 kJ/mol
Boiling Point: 527.9 °C at 760 mmHg
Vapour Pressure: 3.11E-11 mmHg at 25°C
Uses
Donepezil (CAS NO.120014-06-4) is used as an anti-dementia drug. Donepezil has been found to improve sleep apnea in Alzheimer's patients, it also can improve speech in children with autism.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| women | TDLo | oral | 1mg/kg (1mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE GASTROINTESTINAL: NAUSEA OR VOMITING | Annals of Pharmacotherpy. Vol. 33, Pg. 812, 1999. |
Safety Profile
Safety Information of Donepezil (CAS NO.120014-06-4):
Hazard Codes: Xi 
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
RIDADR: UN 2811