Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Dyclonine hydrochloride

Related Products

Hot Products

Basic Information Post buying leads Suppliers
Name

Dyclonine hydrochloride

EINECS 208-633-6
CAS No. 536-43-6 Density N/A
PSA 29.54000 LogP 4.66410
Solubility Partly soluble in water. Soluble in chloroform, ethanol, acetone and methanol. Melting Point 175-176 °C
Formula C18H27NO2.HCl Boiling Point 424.5 °C at 760 mmHg
Molecular Weight 325.879 Flash Point 210.5 °C
Transport Information N/A Appearance White Crystalline Solid
Safety 26-36 Risk Codes 22-37/38-41
Molecular Structure Molecular Structure of 536-43-6 (Dyclonine hydrochloride) Hazard Symbols HarmfulXn
Synonyms

1-Propanone,1-(4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI);Propiophenone,4'-butoxy-3-piperidino-, hydrochloride (7CI,8CI);4'-Butoxy-3-piperidinopropiophenone hydrochloride;Diclonina;Diclonine;Dyclothane;Tanaclone;

 

Dyclonine hydrochloride Synthetic route

50-00-0

formaldehyd

6091-44-7

piperidine hydrochloride

5736-89-0

1-(4-butoxyphenyl)ethan-1-one

536-43-6

dyclonine HCl

Conditions
ConditionsYield
With ethanol
536-43-6

dyclonine HCl

586-60-7

dyclonine

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 10h;87%
536-43-6

dyclonine HCl

A

66536-15-0

1-(4-Butoxyphenyl)-2-propen-1-one

B

1-(4-Butoxyphenyl)-3-hydroxy-1-propanone

Conditions
ConditionsYield
With water at 50℃; for 336h;

Dyclonine hydrochloride Specification

The Dyclonine hydrochloride is an organic compound with the formula C18H27NO2.HCl. The IUPAC name of this chemical is 1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one hydrochloride. With the CAS registry number 536-43-6, it is also named as 1-(2-(4-Butoxybenzoyl)ethyl)piperidine Hydrochloride. The product's categories are Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals. Besides, it should be stored in a cool well-ventilated and dry place. It is used for surface anesthesia.

Physical properties about Dyclonine hydrochloride are: (1)ACD/LogP: 4.67; (2)ACD/LogD (pH 5.5): 1.76; (3)ACD/LogD (pH 7.4): 3.21; (4)ACD/BCF (pH 5.5): 2.58; (5)ACD/BCF (pH 7.4): 72.05; (6)ACD/KOC (pH 5.5): 10.22; (7)ACD/KOC (pH 7.4): 285.31; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 8; (10)Polar Surface Area: 29.54 Å2; (11)Flash Point: 210.5 °C; (12)Enthalpy of Vaporization: 67.9 kJ/mol; (13)Boiling Point: 424.5 °C at 760 mmHg; (14) Vapour Pressure: 2.06E-07 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed and risk of serious damage to eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to respiratory system and skin. When you are using it, wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2
(2)InChI: InChI=1/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H
(3)InChIKey: KNZADIMHVBBPOA-UHFFFAOYAF
(4)Std. InChI: InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H
(5)Std. InChIKey: KNZADIMHVBBPOA-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 9500ug/kg (9.5mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 419, 1955.
dog LDLo oral 40mg/kg (40mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960.
mouse LD50 intraperitoneal 52mg/kg (52mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 410, 1962.
mouse LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: IRRITABILITY

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 419, 1955.
mouse LD50 subcutaneous 37mg/kg (37mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 708, 1958.
mouse LDLo oral 100mg/kg (100mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960.
rabbit LD50 oral 240mg/kg (240mg/kg) BEHAVIORAL: ATAXIA Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960.
rat LD50 intraperitoneal 33mg/kg (33mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 708, 1958.
rat LD50 subcutaneous 201mg/kg (201mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 413, 1955.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 536-43-6