Basic Information | Post buying leads | Suppliers |
Name |
Dyclonine hydrochloride |
EINECS | 208-633-6 |
CAS No. | 536-43-6 | Density | N/A |
PSA | 29.54000 | LogP | 4.66410 |
Solubility | Partly soluble in water. Soluble in chloroform, ethanol, acetone and methanol. | Melting Point |
175-176 °C |
Formula | C18H27NO2.HCl | Boiling Point | 424.5 °C at 760 mmHg |
Molecular Weight | 325.879 | Flash Point | 210.5 °C |
Transport Information | N/A | Appearance | White Crystalline Solid |
Safety | 26-36 | Risk Codes | 22-37/38-41 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
1-Propanone,1-(4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI);Propiophenone,4'-butoxy-3-piperidino-, hydrochloride (7CI,8CI);4'-Butoxy-3-piperidinopropiophenone hydrochloride;Diclonina;Diclonine;Dyclothane;Tanaclone; |
formaldehyd
piperidine hydrochloride
1-(4-butoxyphenyl)ethan-1-one
dyclonine HCl
Conditions | Yield |
---|---|
With ethanol |
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20℃; for 10h; | 87% |
dyclonine HCl
A
1-(4-Butoxyphenyl)-2-propen-1-one
Conditions | Yield |
---|---|
With water at 50℃; for 336h; |
The Dyclonine hydrochloride is an organic compound with the formula C18H27NO2.HCl. The IUPAC name of this chemical is 1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one hydrochloride. With the CAS registry number 536-43-6, it is also named as 1-(2-(4-Butoxybenzoyl)ethyl)piperidine Hydrochloride. The product's categories are Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals. Besides, it should be stored in a cool well-ventilated and dry place. It is used for surface anesthesia.
Physical properties about Dyclonine hydrochloride are: (1)ACD/LogP: 4.67; (2)ACD/LogD (pH 5.5): 1.76; (3)ACD/LogD (pH 7.4): 3.21; (4)ACD/BCF (pH 5.5): 2.58; (5)ACD/BCF (pH 7.4): 72.05; (6)ACD/KOC (pH 5.5): 10.22; (7)ACD/KOC (pH 7.4): 285.31; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 8; (10)Polar Surface Area: 29.54 Å2; (11)Flash Point: 210.5 °C; (12)Enthalpy of Vaporization: 67.9 kJ/mol; (13)Boiling Point: 424.5 °C at 760 mmHg; (14) Vapour Pressure: 2.06E-07 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed and risk of serious damage to eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to respiratory system and skin. When you are using it, wear suitable protective clothing.
You can still convert the following datas into molecular structure:
(1)SMILES: Cl.O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2
(2)InChI: InChI=1/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H
(3)InChIKey: KNZADIMHVBBPOA-UHFFFAOYAF
(4)Std. InChI: InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H
(5)Std. InChIKey: KNZADIMHVBBPOA-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 9500ug/kg (9.5mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 419, 1955. |
dog | LDLo | oral | 40mg/kg (40mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: NAUSEA OR VOMITING | Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960. |
mouse | LD50 | intraperitoneal | 52mg/kg (52mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 410, 1962. | |
mouse | LD50 | intravenous | 20mg/kg (20mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: IRRITABILITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 419, 1955. |
mouse | LD50 | subcutaneous | 37mg/kg (37mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 708, 1958. | |
mouse | LDLo | oral | 100mg/kg (100mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960. | |
rabbit | LD50 | oral | 240mg/kg (240mg/kg) | BEHAVIORAL: ATAXIA | Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960. |
rat | LD50 | intraperitoneal | 33mg/kg (33mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 708, 1958. | |
rat | LD50 | subcutaneous | 201mg/kg (201mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 413, 1955. |