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Name	Emetine	EINECS	N/A
CAS No.	483-18-1	Density	1.17g/cm³
PSA	52.19000	LogP	6.01210
Solubility	961.3mg/L(15 oC)	Melting Point	89-96°C
Formula	C29H40 N2 O4	Boiling Point	600.3°Cat760mmHg
Molecular Weight	480.648	Flash Point	316.9°C
Transport Information	N/A	Appearance	N/A
Safety	A human poison by an unspecified route. An experimental poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by subcutaneous route: muscle weakness, cardiac arrhythmias, and gastrointestinal effects. Mutation data reported. A severe eye and moderate skin irritant. It is one of the two potent alkaloids obtained from the Brazilian plant ipecac. The therapeutic use of various ipecac preparations has caused many cases of poisoning, in some instances with fatal results. The toxic effects are particularly prominent if the drug is given intravenously. The symptoms of intoxication are gastrointestinal irritation and salivation, as well as general edema, which follows renal insufficiency, hemoptysis (blood-stained sputum), flaccid paralysis, peripheral neuritis (inflammation of the nerve endings), aphonia (loss of voice), difficulties in swallowing, delirium, coma, and failure of the heart. The fatal dose is considered to be approximately 2 g, whether administered over a short or relatively long period. The drug seems to have a cumulative effect. When heated to decomposition it emits highly toxic fumes of NO_x.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	Toxic by ingestion.
Synonyms	Emetan,6',7',10,11-tetramethoxy-; Emetine (8CI); (-)-Emetine; Cephaeline methyl ether;Emetin; NSC 33669	Article Data	20

Emetine Chemical Properties

Molecular Structure of Emetine (CAS NO.483-18-1):

IUPAC: (2S,3R,11bS)-2-{[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline
Molecular Formula:C₂₉H₄₀N₂O₄
Molecular Weight:480.64
EINECS:207-592-1
Density:1.17 g/cm³
Boiling Point:600.3^oC at 760 mmHg
Flash Point:316.9^oC
Index of Refraction:1.593
Vapor pressure:2.27E-14 mmHg at 25^oC
Molar Volume:407.9 cm³
Surface Tension:50.4 dyne/cm
Molar Refractivity:138.42 cm³
Enthalpy of Vaporization:89.36 kJ/mol

Emetine Toxicity Data With Reference

1.	skn-rbt 5 mg/24H rns	TXCYAC Toxicology. 14 (1979),117.
2.	skn-rbt 1%/24H MOD	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB-274-082 .
3.	eye-rbt 2000 ppm SEV	AJOPAA American Journal of Ophthalmology. 31 (1948),837.
4.	dnd-mam:lym 6600 µmol/L	FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, CS-112 29 Prague 1, 15 (1970),76.
5.	scu-man TDLo:10 mg/kg/10D:GIT,CNS,CVS	CCROBU Cancer Chemotherapy Reports, Part 1. 57 (1973),423.
6.	unr-man LDLo:2941 µg/kg	85DCAI Poisoning; Toxicology, Symptoms, Treatments. 2 (1970),73.
7.	orl-rat LD50:68 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 13 (1963),474.
8.	ipr-rat LD50:12 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 104 (1952),421.
9.	scu-rat LD50:95 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 13 (1963),474.
10.	ipr-mus LD50:12 mg/kg	JPETAB Journal o

Emetine Consensus Reports

NCI Carcinogenesis Studies (ipr); Inadequate Studies: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-43 ,1977.

Emetine Safety Profile

A human poison by an unspecified route. An experimental poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by subcutaneous route: muscle weakness, cardiac arrhythmias, and gastrointestinal effects. Mutation data reported. A severe eye and moderate skin irritant. It is one of the two potent alkaloids obtained from the Brazilian plant ipecac. The therapeutic use of various ipecac preparations has caused many cases of poisoning, in some instances with fatal results. The toxic effects are particularly prominent if the drug is given intravenously. The symptoms of intoxication are gastrointestinal irritation and salivation, as well as general edema, which follows renal insufficiency, hemoptysis (blood-stained sputum), flaccid paralysis, peripheral neuritis (inflammation of the nerve endings), aphonia (loss of voice), difficulties in swallowing, delirium, coma, and failure of the heart. The fatal dose is considered to be approximately 2 g, whether administered over a short or relatively long period. The drug seems to have a cumulative effect. When heated to decomposition it emits highly toxic fumes of NO_x.

Safty informations about Emetine (CAS NO.483-18-1):
RIDADR:1544
HazardClass:6.1(b)
PackingGroup:III

Emetine Specification

Emetine with cas registry number of 483-18-1 is also known as Emetine ; Emetine HCL BP/USP ; 6',7',10,11-Tetramethoxymetan ; Cephaeline methyl ether ; Canforemetina、emetine hydrochloride ; Emetine (base and/or unspecified salts) ; (1R)-1-[[(2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine-2-yl]methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline ; 6',7',10,11-Tetramethoxyemetan . Emetine is a bitter-tasting crystalline alkaloid, which derived from ipecac root or produced synthetically. It is used in the treatment of amebiasis and as an emetic.

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