Molecular Structure of Estrone (CAS NO.53-16-7):

Molecular Formula: C₁₈H₂₂O₂
Molecular Weight: 270.3661
IUPAC Name: (8R,9S,13S,14S)-3-Hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
CAS NO: 53-16-7
EINECS: 200-164-5
Classification Code: Drug / Therapeutic Agent ; Estrogen ; Estrogens ; Hormone ; Hormones ; Hormones, Hormone Substitutes, and Hormone Antagonists ; Human Data ; Mutation data ; Natural Product ; Reproductive Effect ; Tumor data
Melting point: 258-260 °C 
Index of Refraction: 1.587
Molar Refractivity: 78.04 cm³
Molar Volume: 232.1 cm³
Surface Tension: 46 dyne/cm
Density: 1.164 g/cm³
Flash Point: 189.7 °C
Enthalpy of Vaporization: 73.02 kJ/mol
Boiling Point: 445.2 °C at 760 mmHg
Vapour Pressure: 1.54E-08 mmHg at 25 °C
alpha :158 °(c=1, dioxane)
refractive index: 165 °(C=1, Dioxane)
Water Solubility: 0.03 g/L
Product Categories: Steroids; Various Metabolites and Impurities; 17-Ketosteroids; Biochemistry; Hydroxyketosteroids; Metabolites & Impurities

 Estrone (CAS NO.53-16-7) is mainly used as a metabolite of 17-Estradiol.

NTP 10th Report on Carcinogens. Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 6 , 1974,p. 123.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: )IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 , 1979,p. 343.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.

Hazard Codes of Estrone (CAS NO.53-16-7): T
Risk Statements: 45-60-61 
R45: May cause cancer. 
R60: May impair fertility. 
R61: May cause harm to the unborn child.
Safety Statements: 53-45 
S53: Avoid exposure - obtain special instructions before use. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: KG8575000
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A poison by intraperitoneal and subcutaneous routes. Human reproductive effects by implantation: spermatogenesis and impotence. Mutation data reported. A steroid drug for the treatment of menopause and ovariectomy symptoms. When heated to decomposition it emits acrid smoke and irritating fumes.

Synonyms of Estrone (CAS NO.53-16-7) are1,3,5(10)-Estratrien-3-ol-17-one ; 1,3,5(10)-Oestratrien-3-ol-17-one ; 3-08-00-01171 (Beilstein Handbook Reference) ; 3-Hydroxy-17-keto-estra-1,3,5-triene ; 3-Hydroxy-17-keto-oestra-1,3,5-triene ; 3-Hydroxy-oestra-1,3,5(10)-trien-17-one ; 3-Hydroxyestra-1,3,5(10)-trien-17-one ; 3-Hydroxyestra-1,3,5(10)-triene-17-one ; Aquacrine ; Crinovaryl ; Cristallovar ; Crystogen ; Destrone ; Disynformon ; E(sub 1) ; Endofolliculina ; Estra-1,3,5(10)-trien-17-one, 3-hydroxy- ; Estrogenic substance ; Estron ; Estrona ; Estrone-A ; Estronum ;  Estrovarin ; Estrugenone ; Estrusol ; Fem-O-Gen ; Femestrone injection ; Femidyn ; Folikrin ; Folipex ; Folisan ; Follestrine ; Follestrol ; Follicular hormone ; Folliculin ; Folliculine ; Folliculine benzoate ; Follicunodis ; Glandubolin ; Hiestrone ; Hormestrin ; Hormofollin ; Hormovarine ; Kestrone ; Ketodestrin ; Ketohydroxy-estratriene ; Ketohydroxyestrin ; Ketohydroxyoestrin ; Kolpon ; Menagen ; Menformon ; Mestronaq ; Natural estrogenic substance-estrone ; Oestrin ; Oestroform ; Oestrone ; Oestronum ; Oestroperos ; Ovex (tablets) ; Ovifollin ; Perlatan ; Solliculin ; Theelin ; Thelestrin ; Thelykinin ; Thynestron ; Tokokin ; Unden ; Unden (pharmaceutical) ; Wynestron ; delta-1,3,5-Estratrien 3beta-ol-17-one ; delta-1,3,5-Oestratrien-3beta-ol-17-one ; delta-1,3,5-estratrien-3-beta-ol-17-one ; delta-1,3,5-oestratrien-3-beta-ol-17-one .