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Conditions | Yield |
---|---|
Stage #1: formaldehyd; carbon monoxide With 1,3,5-Trioxan; hydrogenchloride; oxalic acid In 1,4-dioxane; water; 1,2-dichloro-ethane; toluene at 165℃; under 45004.5 Torr; Stage #2: ethanol In 1,4-dioxane; water; 1,2-dichloro-ethane; toluene at 170℃; under 12001.2 Torr; for 36h; | 98.3% |
Conditions | Yield |
---|---|
With ethanol; C42H44ClN4P2Ru(1+)*Cl(1-); potassium tert-butylate at 80℃; for 5h; Schlenk technique; Inert atmosphere; | 94% |
With Ag/SiO2; hydrogen In ethanol at 84 - 242℃; under 22502.3 - 23402.3 Torr; Temperature; | |
With hydrogen; copper at 210 - 220℃; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 10h; Reflux; | A n/a B 82.8% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 10h; Reflux; | 81.8% |
With sulfuric acid at 60℃; for 3h; | 80% |
With ion exchanger (Dowex 50WX8) In chloroform for 72h; Heating; | 74% |
Conditions | Yield |
---|---|
With water at 25℃; for 24h; Green chemistry; | 80% |
With water; acetic acid In dichloromethane for 72h; Darkness; | 66% |
With copper(II) sulfate at 130℃; for 6h; | 20% |
With hydrogen fluoride | |
With Pt(II)halide; water |
Conditions | Yield |
---|---|
With hydrogenchloride; water at -10 - -5℃; for 4h; Reflux; | 78.85% |
Conditions | Yield |
---|---|
With zeolite MFI-ATSn for 6h; Reagent/catalyst; Time; Sealed tube; Green chemistry; | 69% |
ethanol
betaine
A
ethyl 2-hydroxyacetate
B
N-<(ethoxycarbonyl)methyl>trimethylammonium chloride
Conditions | Yield |
---|---|
With chloroacetic acid ethyl ester at 40℃; for 192h; | A 55% B 66% |
Conditions | Yield |
---|---|
With Amberlite IRA 900 NO2- form In acetonitrile at -15℃; | A 65% B 28% |
Conditions | Yield |
---|---|
With ethyl bromoacetate 1) 22 h, 50 deg C, 2) 90 min, reflux, 3) 50 deg C; | 62% |
IUPAC Name: Ethyl 2-hydroxyacetate
Following is the structure of Ethyl glycolate (CAS NO.623-50-7):
Empirical Formula: C4H8O3
Molecular Weight: 104.1045
EINECS: 210-798-4
Index of Refraction: 1.414
Molar Refractivity: 23.89 cm3
Molar Volume: 95.5 cm3
Density: 1.089 g/cm3
Flash Point: 61.7 °C
Surface Tension: 35.2 dyne/cm
Enthalpy of Vaporization: 45.82 kJ/mol
Boiling Point: 156.7 °C at 760 mmHg
Vapour Pressure: 1.03 mmHg at 25 °C
Appearance of Ethyl glycolate (CAS NO.623-50-7): clear colorless liquid
Product Categories: C2 to C5 ; Carbonyl Compounds ; Esters
Canonical SMILES: CCOC(=O)CO
InChI: InChI=1S/C4H8O3/c1-2-7-4(6)3-5/h5H,2-3H2,1H3
InChIKey: ZANNOFHADGWOLI-UHFFFAOYSA-N
Ethyl glycolate (CAS NO.623-50-7) can be used in organic synthesis . It also can be used as solvents.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rat | LDLo | intraperitoneal | 1500mg/kg (1500mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959. |
Reported in EPA TSCA Inventory.
Moderately toxic by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes of Ethyl glycolate (CAS NO.623-50-7): Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
RTECS: MC5410000
HazardClass: 3.2
PackingGroup: III
Ethyl glycolate , its cas register number 623-50-7. It also can be called Ethyl hydroxyacetate ; Hydroxyacetic acid ethyl ester ; and Acetic acid, 2-hydroxy-, ethyl ester . Ethyl glycolate (CAS NO.623-50-7) should avoid the condition like incompatible materials. It is not compatible with strong oxidizing agents, strong bases. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide. However, its hazardous polymerization has not been reported.