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Cas Database |
| Name |
Ethylparaben |
EINECS | 204-399-4 |
| CAS No. | 120-47-8 | Density | 1.168 g/cm3 |
| PSA | 46.53000 | LogP | 1.56890 |
| Solubility | Soluble in ethanol, ether and acetone, slightly soluble in water | Melting Point |
114-117 °C(lit.) |
| Formula | C9H10O3 | Boiling Point | 297.5 °C at 760 mmHg |
| Molecular Weight | 166.177 | Flash Point | 120.3 °C |
| Transport Information | N/A | Appearance | white crystalline powder |
| Safety | 26-36-24/25 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Benzoicacid, p-hydroxy-, ethyl ester (6CI,8CI);4-(Ethoxycarbonyl)phenol;4-Carbethoxyphenol;4-Hydroxybenzoic acid ethyl ester;Aseptin A;Aseptine A;Aseptoform E;Bonomold OE;E 214;Easeptol;Ethyl 4-hydroxybenzoate;EthylButex;Ethyl nipagin;Ethyl p-hydroxybenzoate;Ethyl parasept;Ethylparaben;Mekkings E;Mycocten;p-(Ethoxycarbonyl)phenol;p-Carbethoxyphenol;p-Hydroxybenzoate ethyl ester; |
Article Data | 191 |
Ethylparaben Synthetic route
| Conditions | Yield |
|---|---|
| With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 90℃; for 0.5h; | 100% |
| With potassium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 3h; | 88% |
| With potassium fluoride; thiophenol In 1-methyl-pyrrolidin-2-one at 100℃; for 1h; | 82% |
- 56441-55-5
ethyl 4-(benzyloxy)benzoate
- 120-47-8
Ethyl 4-hydroxybenzoate
| Conditions | Yield |
|---|---|
| With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 50℃; for 5h; Inert atmosphere; | 99% |
| With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 50℃; for 5h; Inert atmosphere; | 99% |
| Conditions | Yield |
|---|---|
| With ammonium formate; palladium on activated charcoal In methanol for 0.5h; Heating; | 98% |
| Conditions | Yield |
|---|---|
| With ethanol; sulfuric acid at 100℃; for 24h; Neat (no solvent); chemoselective reaction; | 97.22% |
| Conditions | Yield |
|---|---|
| With sulfuric acid for 5h; Reflux; | 97% |
| With sulfuric acid for 24h; Reflux; | 96% |
| With [1-(3-sulfonic acid)]propyl-3-methylimidazolium hydrogen sulfate at 85 - 100℃; for 3h; | 95.8% |
- 13031-45-3
ethyl 4-acetoxybenzoate
- 120-47-8
Ethyl 4-hydroxybenzoate
| Conditions | Yield |
|---|---|
| With Candida cylindracea lipase In di-isopropyl ether; butan-1-ol at 28 - 30℃; for 14h; | 97% |
| With sodium tetrahydroborate; cobalt(II) chloride In ethanol at 0 - 25℃; for 10h; | 94% |
| With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 90℃; for 0.5h; | 87% |
- 153025-65-1
ethyl (4-tert-butyldimethylsilyloxyphenyl)glyoxylate
- 120-47-8
Ethyl 4-hydroxybenzoate
| Conditions | Yield |
|---|---|
| With potassium hydroxide In ethanol at 20℃; for 1.5h; | 97% |
| With sodium phosphate dodecahydrate In N,N-dimethyl-formamide at 20℃; for 2h; chemoselective reaction; | 86% |
| With copper(ll) sulfate pentahydrate In methanol at 100℃; for 0.25h; Microwave irradiation; |
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide In water at 30℃; Green chemistry; | 97% |
| With sodium chlorite In water at 20℃; for 0.5h; | 90% |
| With 10-methylacridine-3(10H)-one; oxygen; N-ethyl-N,N-diisopropylamine In water at 20℃; for 24h; Reagent/catalyst; Time; Irradiation; Green chemistry; | 88% |
| With water; oxygen; copper dichloride at 60℃; under 760.051 Torr; for 24h; | 67% |
- 23676-09-7
ethyl 4-ethoxybenzoate
- 120-47-8
Ethyl 4-hydroxybenzoate
| Conditions | Yield |
|---|---|
| With aluminium trichloride In dichloromethane; ethanethiol for 9.5h; Ambient temperature; | 95.5% |
| With aluminium trichloride In dichloromethane; ethanethiol for 9.5h; Ambient temperature; | 95.5% |
| With aluminium trichloride; ethanethiol |
| Conditions | Yield |
|---|---|
| With 4 A molecular sieve; (Ph3P)PdCl2 In tetrahydrofuran at 100℃; under 22800 Torr; for 24h; | 95% |
| bis-triphenylphosphine-palladium(II) chloride In various solvent(s) at 100℃; under 22800 Torr; for 24h; | 99 % Spectr. |
Ethylparaben Chemical Properties
Empirical Formula: C9H10O3
Molecular Weight: 166.1739 g/mol
EINECS: 204-399-4
Index of Refraction: 1.538
Density: 1.168 g/cm3
Flash Point: 120.3 °C
Melting point: 115-118 °C(lit.)
Storage tempreture: 0-6 °C
Appearance: White crystalline powder
Enthalpy of Vaporization: 55.89 kJ/mol
Boiling Point: 297.5 °C at 760 mmHg
Vapour Pressure: 0.000759 mmHg at 25 °C
Solubility: Soluble in ethanol, ether and acetone, slightly soluble in water
Structure of Ethylparaben (CAS NO.120-47-8):
IUPAC Name: Ethyl 4-hydroxybenzoate
Product Category of Ethylparaben (CAS NO.120-47-8): Pharmaceutical Raw Materials;Aromatic Esters
Ethylparaben Uses
Ethylparaben (CAS NO.120-47-8) is used as a food preservative, and is also used in the pharmaceutical, leather and other industries.
Ethylparaben Production
Ethylparaben (CAS NO.120-47-8) can be obtained from the right-hydroxy benzoic acid and ethanol in the presence of sulfuric acid as catalyst for esterification, after that having them in water for crystallization, and then through filter and pickling to get the product.
Ethylparaben Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 5gm/kg (5000mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. | |
| guinea pig | LD50 | oral | 2gm/kg (2000mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. | |
| mouse | LD50 | intraperitoneal | 520mg/kg (520mg/kg) | Drug Standards. Vol. 20, Pg. 89, 1952. | |
| mouse | LD50 | oral | 3gm/kg (3000mg/kg) | Bromatologia i Chemia Toksykologiczna. Vol. 14, Pg. 301, 1981. | |
| rabbit | LD50 | oral | 5gm/kg (5000mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. | |
| rat | LD | oral | > 200mg/kg (200mg/kg) | Acta Obstetrica et Gynaecologica Japonica, English Edition. Vol. 22, Pg. 94, 1975. |
Ethylparaben Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Ethylparaben Specification
Ethylparaben , its cas register number is 120-47-8. It also can be called Ethyl paraben ; 4-(Ethoxycarbonyl)phenol ; Ethyl 4-hydroxybenzoate ; p-Hydroxybenzoate ethyl ester ; Ethyl butex ; 4-Hydroxybenzoic acid ethyl ester ; and Ethyl p-hydroxybenzoate . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Ethylparaben (CAS NO.120-47-8) is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide.
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