- Fludarabine
- Fludarabine phosphate
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Cas Database |
| Name |
Fludarabine phosphate |
EINECS | 616-242-0 |
| CAS No. | 75607-67-9 | Density | 2.39 g/cm3 |
| PSA | 195.88000 | LogP | -1.14270 |
| Solubility | Soluble in DMSO or water at 5mg/ml | Melting Point |
203°C(dec.)(lit.) |
| Formula | C10H13FN5O7P | Boiling Point | 864.2 °C at 760 mmHg |
| Molecular Weight | 365.215 | Flash Point | 476.4 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | R25 | |
| Molecular Structure |
|
Hazard Symbols |
 T
|
| Synonyms |
Fludarabine phosphate (JAN/USP);Fludarabine 5-monophosphate;9-beta-D-Arabinofuranosyl-2-fluoroadenine 5-(dihydrogen phosphate);Trimeric Sodium Phosphate;[(2R,3R,4S,5R)-5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid;2-Fluoro-ARA AMP;Fludarabine phosphate [USAN:BAN];Fludarabine monophosphate;9-beta-Arabinofuranosyl-2-fluoroadenine-5-phosphate;Fludura;9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-;2-Fluoroadenine arabinoside 5-monophosphate;fludarabine hcl; |
Article Data | 9 |
Fludarabine phosphate Chemical Properties
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IUPAC Name: [5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Molecular Formula: C10H13FN5O7P
Molecular Weight: 365.21 g/mol
Classification Code: Antimetabolites; Antimetabolites, antineoplastic; Antineoplastic; Antineoplastic Agents; Drug / Therapeutic Agent; Human Data; Immunologic Factors; Immunosuppressive agents; Noxae
Product Categories: Active Pharmaceutical Ingredients; Antineoplastics; Antineoplastic; API
XLogP3: -3.1
H-Bond Donor: 5
H-Bond Acceptor: 12
Surface Tension: 130.7 dyne/cm
Density: 2.39 g/cm3
Flash Point: 476.4 °C
Enthalpy of Vaporization: 131.58 kJ/mol
Boiling Point: 864.2 °C at 760 mmHg
Vapour Pressure of Fludarabine phosphate (CAS NO.75607-67-9): 7.38E-32 mmHg at 25 °C
Fludarabine phosphate Uses
Fludarabine phosphate (CAS NO.75607-67-9) is a chemotherapy drug used in the treatment of hematological malignancies. It is highly effective in the treatment of chronic lymphocytic leukemia.
Fludarabine phosphate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | intravenous | 18750mg/kg/5D (18750mg/kg) | BRAIN AND COVERINGS: ENCEPHALITIS SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE | Cancer Treatment Reports. Vol. 70, Pg. 1225, 1986. |
| man | TDLo | intravenous | 11655mg/kg/5D (11655mg/kg) | SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Cancer Treatment Reports. Vol. 70, Pg. 1449, 1986. |
| man | TDLo | intravenous | 17760mg/kg/5D (17760mg/kg) | BRAIN AND COVERINGS: DEMYELINATION BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: COMA | Cancer Treatment Reports. Vol. 70, Pg. 1225, 1986. |
| mouse | LD50 | intravenous | 1236mg/kg (1236mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | National Technical Information Service. Vol. PB83-195685, |
| women | LDLo | intravenous | 14245mg/kg/5D (14245mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: EXCITEMENT SKIN AND APPENDAGES (SKIN): SWEATING: OTHER | Cancer Treatment Reports. Vol. 70, Pg. 1449, 1986. |
| women | TDLo | intravenous | 23125mg/kg/5D (23125mg/kg) | BRAIN AND COVERINGS: ENCEPHALITIS SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Cancer Treatment Reports. Vol. 70, Pg. 1225, 1986 |
Fludarabine phosphate Specification
Fludarabine phosphate (CAS NO.75607-67-9), its Synonyms are Fludarabine monophosphate ; 2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine ; 2-Fluoro-ARA AMP ; 2-Fluoroadenine arabinoside 5'-monophosphate ; 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate ; 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate) ; 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate ; Fludara ; 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)- .
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