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Basic Information
CAS No.: 23155-02-4
Name: Fosfomycin
Molecular Structure:
Molecular Structure of 23155-02-4 (Fosfomycin)
Formula: C3H7O4P
Molecular Weight: 138.06
Synonyms: Phosphonicacid, (1,2-epoxypropyl)-, (1R,2S)-(-)- (8CI);Phosphonic acid, (3-methyloxiranyl)-,(2R-cis)-;Phosphonic acid, [(2R,3S)-3-methyloxiranyl]- (9CI);(-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid;(-)-(cis-1,2-Epoxypropyl)phosphonic acid;(-)-Phosphonomycin;(2R-cis)-(3-Methyloxiranyl)phosphonic acid;Antibiotic 833A;Fosfocina;Fosfomicin;Fosfonomycin;Infectophos;Levo-phosphonomycin;MK0955;Phosphomycin;Phosphonomycin;[(2R,3S)-3-Methyloxiranyl]phosphonic acid;
EINECS: 245-463-1
Density: 1.561 g/cm3
Melting Point: 94 °C
Boiling Point: 342.651 °C at 760 mmHg
Flash Point: 161.03 °C
PSA: 79.87000
LogP: -0.09110
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32986-56-4
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Chemistry

Phosphonomycin is a broad-spectrum antibiotic produced by certain Streptomyces species.It has some synonyms like Fosfomycin;phosphomycin;(3-Methyloxiran-2-yl)phosphonic acid,and so on.

Molecular Formula: C3H7O4P
Molecular Weight: 138.06
EINECS: 245-463-1
Melting point:  94°C

Uses

Phosphonomycin has good effects on Pseudomonas aeruginosa, Proteus mirabilis, E. coli, Serratia and Staphylococcus.It is aslo indicated in the treatment of urinary tract infections.

Toxicity Data With Reference

1.   

pic-esc 10 µg/plate

   CNREA8    Cancer Research. 43 (1983),2819.
2.   

mmo-omi 10 g/L

   MILEDM    Microbios Letters. 8 (1978),27.
3.   

ipr-mus LD50:4000 mg/kg

   85GDA2    CRC Handbook of Antibiotic Compounds, Volumes 1-9. 6 (1981),426.

Safety Profile

Moderately toxic by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of POx.

 

Specification

Phosphonomycin has resistance because mutations that inactivate the non-essential glycerophosphate transporter render bacteria resistant of it.