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Cas Database

Name	Fosfomycin	EINECS	245-463-1
CAS No.	23155-02-4	Density	1.561 g/cm³
PSA	79.87000	LogP	-0.09110
Solubility	N/A	Melting Point	94 °C
Formula	C₃H₇O₄P	Boiling Point	342.651 °C at 760 mmHg
Molecular Weight	138.06	Flash Point	161.03 °C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Phosphonicacid, (1,2-epoxypropyl)-, (1R,2S)-(-)- (8CI);Phosphonic acid, (3-methyloxiranyl)-,(2R-cis)-;Phosphonic acid, [(2R,3S)-3-methyloxiranyl]- (9CI);(-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid;(-)-(cis-1,2-Epoxypropyl)phosphonic acid;(-)-Phosphonomycin;(2R-cis)-(3-Methyloxiranyl)phosphonic acid;Antibiotic 833A;Fosfocina;Fosfomicin;Fosfonomycin;Infectophos;Levo-phosphonomycin;MK0955;Phosphomycin;Phosphonomycin;[(2R,3S)-3-Methyloxiranyl]phosphonic acid;	Article Data	9

Fosfomycin Chemical Properties

Phosphonomycin is a broad-spectrum antibiotic produced by certain Streptomyces species.It has some synonyms like Fosfomycin;phosphomycin;(3-Methyloxiran-2-yl)phosphonic acid,and so on.

Molecular Formula: C₃H₇O₄P
Molecular Weight: 138.06
EINECS: 245-463-1
Melting point: 94°C

Fosfomycin Uses

Phosphonomycin has good effects on Pseudomonas aeruginosa, Proteus mirabilis, E. coli, Serratia and Staphylococcus.It is aslo indicated in the treatment of urinary tract infections.

Fosfomycin Toxicity Data With Reference

1.	pic-esc 10 µg/plate	CNREA8 Cancer Research. 43 (1983),2819.
2.	mmo-omi 10 g/L	MILEDM Microbios Letters. 8 (1978),27.
3.	ipr-mus LD₅₀:4000 mg/kg	85GDA2 CRC Handbook of Antibiotic Compounds, Volumes 1-9. 6 (1981),426.

Fosfomycin Safety Profile

Moderately toxic by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of PO_x.

Fosfomycin Specification

Phosphonomycin has resistance because mutations that inactivate the non-essential glycerophosphate transporter render bacteria resistant of it.

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