Probes for Narcotic Receptor Mediated Phenomena. 9. Synthesis of (+/-)-(3α,6aα,11aβ)-1,3,4,5,6,11a-Hexahydro-2-methyl-2H-3,6a-methanobenzofuroazocin-10-ol, an Oxide-Bridged 5-(m-Hydroxyphenyl)morphan

DOI: 10.1021/jm00155a026

Source and publish data:

Journal of Medicinal Chemistry p. 748 - 751 (1986)

Update date:2022-08-04

Topics:

Authors:

Burke, Terrence R.

Jacobson, Arthur E.

Rice, Kenner C.

Weissman, Ben Avi

Huang, Hsueh-Cheng

Silverton, J. V.

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Article abstract of DOI:10.1021/jm00155a026

The synthesis of racemic (3α,6aα,11aβ)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a-methanobenzofuro<2,3-c>azocin-10-ol (2d) is described.The route used acid-catalyzed ring closure of enamine 5 to yield the unsaturated phenylmorphan 6.Conversion of 6 to oxide

Full text of DOI:10.1021/jm00155a026

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