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9004-34-6 Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 9004-34-6 differently. You can refer to the following data:
1. Microcrystalline cellulose and carboxymethylcellulose sodium occurs as a white or off-white odorless and tasteless hygroscopic powder containing 5–22% sodium carboxymethylcellulose. It is a water-dispersible organic hydrocolloid.
2. Microcrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. It is commercially available in different particle sizes and moisture grades that have different properties and applications.


The fiber in typical paper can be called “cellulosic”, meaning that cellulose is its most prominent component. Cellulose is present not only in wood, but also in various non-woody plants, such as straw, sugarcane (bagasse), reeds, and hemp.


Different sources of media describe the Uses of 9004-34-6 differently. You can refer to the following data:
1. High purity cellulose powders for partition chromatography.
2. ACCEL-101 is most widely used for direct compression tableting and wet granulation. ACCEL-102 has similar compression properties to ACCEL-101. However, it has larger particle size and therefore, may be of value in improving the flow if fine powders. ACCEL
3. cellulose is a thickener and an emulsifier. It is obtained from plants. cellulose (microcrystalline) is used as an emulsifier in cosmetic creams. It is the chief constituent of plant fiber.
4. Wood contains 50–70% cellulose; cotton and other textile fibers of plant origin contain 65–95%; rayon is prepared by dissolving natural cellulose and then precipitating it from solution, with some loss of crystallinity. Cellulose is made into cellophane film and is used to form fibers, resins, coatings and gums.
5. Cellulose is a carbohydrate polymer made up of glucose units. It consists of fibrous particles and is used as a fiber source and bulking agent in low-calorie formulations.
6. Microcrystalline Cellulose is a gum that is the nonfibrous form of cellulose, an alpha-cellulose. It is dispersible in water but not soluble, requiring considerable energy to disperse and hydrate. In this form it is used in dry applications such as tableting, capsules, and shredded cheese where it functions as a non-nutritive filler, binder, flow aid, and anticaking agent. By the addition of carboxymethylcellulose to the alpha-cellulose prior to drying, improved functional properties of hydration and dispersion are obtained. This product is designed for use in water dispersions, being insoluble in water but dispersing in water to form colloidal sols below 1% and white opaque gels above the 1% usage level. It is used as a heat shock stabilizer and bodying agent in frozen desserts, as an opacifier in low-fat dressings, as a foam stabilizer in whipped toppings, and as an emulsifier in dressings. Also termed cellulose gel.


A natural carbohydrate high polymer (polysaccha- ride) consisting of anhydroglucose units joined by an oxygen linkage to form long molecular chains that are essentially linear. It can be hydrolyzed to glucose. The degree of polymerization is from 1000 for wood pulp to 3500 for cotton fiber, giving a molecular weight from 160,000 to 560,000. Cellulose is a colorless solid, d approximately 1.50, insoluble in water and organic solvents. It will swell in sodium hydroxide solution and is soluble in Schweitzer’s reagent. It is the fundamental con- stituent of all vegetable tissues (wood, grass, cotton, etc.) and the most abundant organic material in the world. Cotton fibers are almost pure cellulose; wood contains approximately 50%. The physical structure of cellulose is unusual in that it is not a single crystal but consists of crystalline areas embedded in amorphous areas. Chemical reagents penetrate the latter more easily than the former. Cel- lulose is virtually odorless and tasteless and is com- bustible, with an ignition point of approximately 450F. In some forms, it is flammable. For example, railroad shipping regulations require a flammable label on such items as burnt fiber, burnt cotton, wet waste paper, and wet textiles. Fires have been known to occur in warehouses in which telephone books were stored. These were undoubtedly due to heat buildup in the paper caused by microbial activity and self-sustaining oxidation.

Production Methods

Different sources of media describe the Production Methods of 9004-34-6 differently. You can refer to the following data:
1. Microcrystalline cellulose and carboxymethylcellulose sodium is a spray- or bulk-dried blend of microcrystalline cellulose and sodium carboxymethylcellulose. It is prepared by the chemical depolymerization of highly purified wood pulp. The original crystalline areas of the pulp fibers are combined with sodium carboxymethylcellulose, which serves as a protective colloid and also facilitates dispersion of the product; it is then either spray- or bulk-dried.
2. Microcrystalline cellulose is manufactured by controlled hydrolysis with dilute mineral acid solutions of α-cellulose, obtained as a pulp from fibrous plant materials. Following hydrolysis, the hydrocellulose is purified by filtration and the aqueous slurry is spraydried to form dry, porous particles of a broad size distribution.

General Description

Odorless, white powdery fibers. Density 1.5 g cm-3. The biopolymer composing the cell wall of vegetable tissues. Prepared by treating cotton with an organic solvent to de-wax Cellulose microcrystalline and removing pectic acids by extration with a solution of sodium hydroxide. The principal fiber composing the cell wall of vegetable tissues (wood, cotton, flax, grass, etc.). Technical uses depend on the strength and flexibility of its fibers. Insoluble in water. Soluble with chemical degradation in sulfuric aicd, and in concentrated solutions of zinc chloride. Soluble in aqueous solutions of cupric ammonium hydroxide (Cu(NH3)4(OH)2).

Reactivity Profile

Cellulose microcrystalline is combustible. Incompatible with strong oxidizing agents including bromine pentafluoride, sodium nitrate, fluorine, perchlorates, perchloric acid, sodium chlorate, magnesium perchlorate, F2, zinc permanganate, sodium nitrite, sodium nitrate, sodium peroxide. Nitration with a mixture of nitric and sulfuric acids produces Cellulose microcrystalline nitrates (celluloid pyroxylin, soluble pyroxyline, guncotton) which are flammable or explosive.

Health Hazard

Cellulose is inert and is classified as a nuisance dust. It has little, if any, adverse effect on the lung, and there are no reports of organic disease or toxic effect. The health effects attributed to wood, cotton, flax, jute, and hemp are not attributable to their cellulose content but rather to the presence of other substances. Cellulose fibers were found in the blood and urine of human volunteers fed dyed cellulose; there were no ill effects.

Pharmaceutical Applications

Microcrystalline cellulose and carboxymethylcellulose sodium is used to produce thixotropic gels suitable as suspending vehicles in pharmaceutical and cosmetic formulations. The sodium carboxymethylcellulose aids dispersion and serves as a protective colloid. Concentrations of less than 1% solids produce fluid dispersions, while concentrations of more than 1.2% solids produce thixotropic gels. When properly dispersed, it imparts emulsion stability, opacity and suspension in a variety of products, and is used in nasal sprays, topical sprays and lotions, oral suspensions, emulsions, creams and gels.

Industrial uses

Cellulose is the main constituent of the structureof plants (natural polymer) that, whenextracted, is employed for making paper,plastics, and in many combinations. Celluloseis made up of long-chain molecules inwhich the complex unit C6H10O5 is repeatedas many as 2000 times. It consists of glucose molecules with three hydroxyl groups foreach glucose unit.One of the simplest forms of cellulose usedindustrially is regenerated cellulose, in whichthe chemical composition of the finished productis similar to that of the original cellulose. Itis made from wood or cotton pulp digested ina caustic solution. Cellophane is a regeneratedcellulose in thin sheets for wrapping and otherspecial uses include windings on wire andcable.

Biochem/physiol Actions

Cellulose helps in maintaining the structural stability of plant cell walls. It is an important component of paper and fabrics made from cotton, and linen.


Microcrystalline cellulose is widely used in oral pharmaceutical formulations and food products and is generally regarded as a relatively nontoxic and nonirritant material. Microcrystalline cellulose is not absorbed systemically following oral administration and thus has little toxic potential. Consumption of large quantities of cellulose may have a laxative effect, although this is unlikely to be a problem when cellulose is used as an excipient in pharmaceutical formulations. Deliberate abuse of formulations containing cellulose, either by inhalation or by injection, has resulted in the formation of cellulose granulomas.


Microcrystalline cellulose and carboxymethylcellulose sodium is hygroscopic and should not be exposed to moisture. It is stable over a pH range of 3.5–11. Store in a cool, dry place. Avoid exposure to excessive heat.


Microcrystalline cellulose is incompatible with strong oxidizing agents.

Regulatory Status

Microcrystalline cellulose and carboxymethylcellulose sodium is a mixture of two materials both of which are generally regarded as nontoxic: Microcrystalline cellulose GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; oral capsules, powders, suspensions, syrups, and tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Carboxymethylcellulose sodium GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intra-articular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Check Digit Verification of cas no

The CAS Registry Mumber 9004-34-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 4 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 9004-34:
76 % 10 = 6
So 9004-34-6 is a valid CAS Registry Number.

9004-34-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A17730)  Cellulose, microcrystalline   

  • 9004-34-6

  • 500g

  • 421.0CNY

  • Detail
  • Alfa Aesar

  • (A17730)  Cellulose, microcrystalline   

  • 9004-34-6

  • 2500g

  • 1590.0CNY

  • Detail
  • Alfa Aesar

  • (A17730)  Cellulose, microcrystalline   

  • 9004-34-6

  • 10000g

  • 5612.0CNY

  • Detail
  • Sigma

  • (C8002)  α-Cellulose  powder

  • 9004-34-6

  • C8002-1KG

  • 324.09CNY

  • Detail
  • Sigma

  • (C8002)  α-Cellulose  powder

  • 9004-34-6

  • C8002-5KG

  • 1,118.52CNY

  • Detail
  • Sigma-Aldrich

  • (22197)  Cellulose  DS-0, powder, for thin layer chromatography

  • 9004-34-6

  • 22197-250G-F

  • 727.74CNY

  • Detail
  • Sigma-Aldrich

  • (09906)  Cellulose  DFS-0, microcrystalline, for thin layer chromatography

  • 9004-34-6

  • 09906-1KG

  • 2,148.12CNY

  • Detail
  • Sigma

  • (S3504)  Sigmacell Cellulose  Type 20, 20 μm

  • 9004-34-6

  • S3504-500G

  • 527.67CNY

  • Detail
  • Sigma

  • (S3504)  Sigmacell Cellulose  Type 20, 20 μm

  • 9004-34-6

  • S3504-1KG

  • 975.78CNY

  • Detail
  • Sigma

  • (S5504)  Sigmacell Cellulose  Type 50, 50 μm

  • 9004-34-6

  • S5504-500G

  • 538.20CNY

  • Detail
  • Sigma

  • (S5504)  Sigmacell Cellulose  Type 50, 50 μm

  • 9004-34-6

  • S5504-1KG

  • 927.81CNY

  • Detail
  • Sigma

  • (S6790)  Sigmacell Cellulose  Type 101, Highly purified, fibers

  • 9004-34-6

  • S6790-100G

  • 276.12CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name (1→4)-β-D-glucan

1.2 Other means of identification

Product number -
Other names Cellulose microcrystalline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:9004-34-6 SDS

9004-34-6Relevant articles and documents

A new protection group strategy for cellulose in an ionic liquid: simultaneous protection of two sites to yield 2,6-di-O-substituted mono-p-methoxytrityl cellulose

Granstr?m, Mari,Olszewska, Anna,M?kel?, Valtteri,Heikkinen, Sami,Kilpel?inen, Ilkka

, p. 1744 - 1747 (2009)

Increased reactivity of cellulose in ionic liquids was revealed when cellulose was protected with a 4-methoxytrityl moiety in the imidazolium-based ionic liquid, 1-allyl-3-methylimidazolium chloride ([amim]Cl). Selectively protected 2,6-di-O-(4-methoxytri

Vacuum-assisted layer-by-layer electrospun membranes: Antibacterial and antioxidative applications

Zhou, Bin,Jin, Xing,Li, Jing,Xu, Wei,Liu, Shilin,Li, Yan,Li, Bin

, p. 54517 - 54524 (2014)

Layer-by-layer assembled films have been exploited for functional materials. Tannic acid with previously confirmed antibacterial and antioxidant potentials was deposited on cellulose nanofibrous mats. The LbL assembly technique allowed sufficient binding of TA and AgNPs-Lys to the supporting substrate via hydrogen bond and electrostatic interactions. The properties and morphology of the AgNPs-Lys/TA multilayer assembly membranes were characterized by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectra (FT-IR), wide-angle X-ray diffraction (XRD), and scanning electron microscopy (SEM). The antibacterial and antioxidant activities were examined as well. The hybrid composite films have potential application in food packing and wound dressing, and tissue engineering, etc. This journal is

Layer-by-layer structured polysaccharides film-coated cellulose nanofibrous mats for cell culture

Deng, Hongbing,Zhou, Xue,Wang, Xiaoying,Zhang, Chunyan,Ding, Bin,Zhang, Qiuhua,Du, Yumin

, p. 474 - 479 (2010)

For the first time, a novel fibrous polysaccharide scaffold for cell culture was fabricated by the combination of electrospinning and electrostatic layer-by-layer (LBL) self-assembly technique. Oppositely charged chitosan (CS) and alginate (ALG) in aqueous media were alternatively deposited onto the negatively charged cellulose nanofibrous mats which hydrolyzed from electrospun cellulose acetate mats. The morphology and biocompatibility of the resultant scaffolds were investigated by regulating the pH of dipping solutions, the number of deposition bilayers, and the composition of outermost layer. Field emission scanning electron microscopy images indicated that the scaffolds possessed the fibrous structure and the thickness of CS/ALG bilayer formed on fibers was estimated in the range of 8-15 nm. The X-ray photoelectron spectroscopy results verified the existence of nitrogen element of CS on the surface of LBL films. The cell culture experiments demonstrated that the scaffolds have good biocompatibility for Beas-2B human bronchial epithelial cells in vitro.

Regioselective synthesis of lipophilic dithiocarbamate derivatives of cellulose to prepare a novel solvent extraction reagent for selective extraction of PGM ions and Cu(II)

Dhakal, Rabindra Prasad,Inoue, Katsutoshi,Ohto, Keisuke,Baba, Yoshinari

, p. 1064 - 1065 (2006)

Regenerated cellulose from cellulose triacetate was regiose-lectively converted into its lipophilic amino and dithiocarbamate derivatives to prepare novel solvent extraction reagents with series of substitutions and deoxy substitution reaction. The 6-de-oxydithiocarbamate-2,3-didecyl cellulose prepared in this work significantly demonstrated the high lipophilicity coupled with high selectivity for PGM ions and also to the Cu(II) over Ni(II) and Zn(II) in liquid-liquid extraction. Copyright

Functionalized Celluloses with Regular Substitution Pattern by Glycosynthase-Catalyzed Polymerization

Codera, Victoria,Edgar, Kevin J.,Faijes, Magda,Planas, Antoni

, p. 1272 - 1279 (2016/05/09)

Control of the monomer sequence in polymers is extraordinarily difficult by chemical synthesis, though Nature routinely exerts such control, including in the biosynthesis of polysaccharides. This inability has prevented us from being able to match the exquisite structure-activity control exhibited in biosynthesis of bioactive natural polysaccharides. We here address a powerful approach, whereby enzyme-catalyzed polymerization of properly modified building blocks is introduced as a simple route affording polysaccharides with controlled sequence and functionalization pattern. Targeting cellulose as a versatile scaffold for novel biomaterials, we describe the preparation of a perfectly alternating polysaccharide with repeat unit 6′-azido-6′-deoxycellobiose by a glycosynthase-catalyzed polymerization using the Humicola insolens cellulase Cel7B E197A mutant, and its further functionalization to give novel modified cellulose derivatives with a regular substitution pattern.

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