MedChemComm p. 653 - 664 (2015)
Update date:2022-08-02
Topics:
He, Xiaomeng
Jiang, Yan
Zhang, Yongqiang
Wu, Shanchao
Dong, Guoqiang
Liu, Na
Liu, Yang
Yao, Jianzhong
Miao, Zhenyuan
Wang, Yan
Zhang, Wannian
Sheng, Chunquan
Due to increasing incidence and mortality of invasive fungal infections, discovery and development of new generations of antifungal agents represents a challenging task. On the basis of our previously reported triazole-benzyloxypiperidinyl lead compound, a series of novel triazole antifungal agents containing piperidine-oxadiazole side chains were rationally designed and synthesized. Most of the target compounds showed excellent inhibitory activity against clinically important fungal pathogens. In particular, compounds 6g (MIC = 0.031 μg mL-1) and 11b (MIC = 0.016 μg mL-1) were highly active against Candida albicans including fluconazole-resistant strains. Moreover, they showed inhibitory activity against hyphal formation with low toxicity, which were promising leads for further development. This journal is
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