Journal of Medicinal Chemistry p. 322 - 324 (1980)
Update date:2022-08-04
Topics:
Grol, Cor J.
Rollema, Hans
Dijkstra, Durk
Westernik, Ben H. C.
The synthesis of thieno<2,3-b>-, thieno<3,4-b>-, and thieno<3,2-b>benzothiazines with a hydroxyethylpiperazinylpropyl side chain and various 2 substituents is described.The influence of these neuroleptic compounds on dopamine metabolism in vivo is quantitated by determining the rise in homovanillic acid concentrations in rat corpus striatum.Notable differences in activity were found among the isomers, which were useful for structure-activity correlations in the phenothiazine neuroleptics.
View MoreJinan Yijialian Economic and Trade Development Co., Ltd.
Contact:+86 0531-66729596
Address:jinan
Shanghai Rainbow Chemistry Co., Ltd.
Contact:+86-21-64968086-5815/5812
Address:3rd floor, Building 7, 251 Faladi Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai, P.R. China
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
TAIXING BEST NEW MATERIALS CO., LTD
Contact:0523-87998158;
Address:No.18 Zhonggang Road，Taixing City ，Jiangsu , China
Hunan Haili Chemical Industry Co.,Ltd.
Contact:+86-731-85521860
Address:No.251, 2nd Section, Furong Road, Changsha,Hunan,China
Doi:10.1002/chem.200701043
(2008)Doi:10.1002/anie.200705420
(2008)Doi:10.1016/j.carres.2007.12.001
(2008)Doi:10.1016/j.jorganchem.2007.12.028
(2008)Doi:10.1021/ja01561a045
(1957)Doi:10.1002/chem.201700831
(2017)
