Organic Synthesis with Enzymes. 3. TBADH-Catalyzed Reduction of Chloro Ketones. Total Synthesis of (+)-(S,S)-(cis-6-Methyltetrahydropyran-2-yl)acetic Acid: A Civet Constituent

DOI: 10.1021/ja00272a051

Source and publish data:

Journal of the American Chemical Society p. 3474 - 3480 (1986)

Update date:2022-08-05

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Authors:

Keinan, Ehud

Seth, Kamal K.

Lamed, Raphael

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Article abstract of DOI:10.1021/ja00272a051

Highly enantioselective reduction of aliphatic chloro ketones catalyzed by Thermoanaerobium brockii alcohol dehydrogenase (TBADH) afforded the corresponding S chloro alcohols, which are new and useful chiral bifunctional building blocks.The synthetic pote

Full text of DOI:10.1021/ja00272a051

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