Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin

DOI: 10.1021/jm010332u

Source and publish data:

Journal of Medicinal Chemistry p. 670 - 675 (2002)

Update date:2022-08-04

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Authors:

Haramura, Masayuki

Okamachi, Akira

Tsuzuki, Kouichi

Yogo, Kenji

Ikuta, Makoto

Kozono, Toshiro

Takanashi, Hisanori

Murayama, Eigoro

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Article abstract of DOI:10.1021/jm010332u

A series of cyclic peptides having the general structure H-Phe-c[-N^ε-Lys-X-NH-(CH₂)_n-CO-] were designed on the basis of structure-activity relationship studies of motilin. All were motilin antagonists. The cyclic peptides,

Full text of DOI:10.1021/jm010332u

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